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박창한 ( Chang Han Park ),김경묵 ( Kyung Mook Kim ),김희규 ( Hee Gyu Kim ),손성욱 ( Seoung Wook Son ),김상헌 ( Sang Heon Kim ),박흥우 ( Heung Woo Park ),장윤석 ( Yoon Seok Chang ),김선신 ( Sun Sin Kim ),김윤근 ( Yoon Keun Kim ) 대한천식알레르기학회 2005 천식 및 알레르기 Vol.25 No.4
Mastocytosis is a rare disease characterized by pathologically increased mast cells in various tissues. Cutaneous mastocytosis, the most common manifestation of the mastocytosis, is confined to the skin without involvement of the other organs. Cutaneous mastocytosis is mostly found in children. It usually presents as symmetrically distributed red-brown macules or papules. Wheals and erythema may often develop with pruritus if mechanical irritations such as stroking (Darier`s sign), heat or sudden change of temperature are given to the skin lesions. Clinical symptoms include flushing, urticaria, angioedema, anaphylaxis, peptic ulcer disease, abdominal pain, diarrhea and bone pain caused by the release of mast cell mediators. We report a case of adult-onset cutaneous mastocytosis that presented as generalized urticaria developed after hot bath. (Korean J Asthma Allergy Clin Immunol 2005;25:328-332)
양민석 ( Min Suk Yang ),이소희 ( So Hee Lee ),김경묵 ( Kyung Mook Kim ),권혁수 ( Hyouk Soo Kwon ),김덕인 ( Deok In Kim ),박창한 ( Chang Han Park ),손성욱 ( Seoung Wook Son ),박흥우 ( Heung Woo Park ),장윤석 ( Yoon Seok Chang ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.3
We here report a case with apple-dependent exercise-induced anaphylaxis, the first case in Korea. A 23-year-old Korean female patient presented with urticaria, angioedema, and dizziness during mountain climbing. A detailed clinical history revealed that she ingested apple 30 minutes before mountain climbing. Prick to prick skin test to apple showed a positive result. The exercise provocation test or the oral challenge test alone showed a negative result. However, the exercise provocation test after apple ingestion resulted in severe anaphylactic reaction. She was diagnosed as having food-dependent exercise-induced anaphylaxis to apples, and was instructed to avoid exercise after apple ingestion in the future. (Korean J Asthma Allergy Clin Immunol 2006;26: 242-245)