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아토피피부염에서 임상적 중증도에 따른 알레르기 검사소견
성현철 ( Hyun Chul Sung ),이원주 ( Weon Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.9
Background: The serum levels of serum total IgE, peripheral eosinophils and eosinophil cationic protein (ECP) are known to be elevated in patients with atopic dermatitis. However, the relationship between these laboratory findings and the clinical severity of atolpic dermatitis is controversial. Objective: The purpose of this study was to evaluate serum total IgE, peripheral eosinophil counts, ECP as severity indices or disease markers of atopic dermatitis in Korea. Methods: One hundred and thirty patients were evaluated for the symptoms and signs of atopic dermatitis, and classified into a mild, moderate or severe group according to the clinical severity. We measured for total serum IgE, peripheral eosinophil counts, ECP and assessed allergen-specific IgE using multiple allergosorbent test-chemiluminescent assay (MAST-CLA) and CAP-fluoroenzyme immunoassay (CAP-FEIA). Results: Serum total IgE and peripheral eosinophil counts of patients with atopic dermatitis showed a statistically significant correlation with the clinical severity (p<0.05). Patients from the severe atopic dermatitis group revealed significantly higher ECP level than those in the mild or moderate group (p<0.05). The most common inhalant allergen was D. farinae, followed by D. pteronyssinus, housedust, and the most common food allergen was wheat, followed by soyabean and egg white. Conclusion: Total serum IgE, peripheral eosinophils and eosinophil cationic protein (ECP) were good indices reflecting the severity of atopic dermatitis. (Korean J Dermatol 2006;44(9):1051~1057)
성현철 ( Hyun Chul Sung ),정홍대 ( Hong Dae Jung ),박경덕 ( Kyung Duck Park ),이원주 ( Weon Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ),전종택 ( Jong Taek Jeon ),김영주 ( Young Ju Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.7
Background: In the last few decades, there has been a substantial increase in the population of aged people. Aging skin is a common concern for many people these days. Objective: The purpose of this study was to evaluate the efficacy of cosmetics containing Ascidian tunic in reducing wrinkles. Methods: Cream containing the Ascidian tunic was applied to right lateral epicanthal areas of 30 subjects for 8 weeks. As control group, a placebo which does not contain the Ascidian tunic was applied to the left lateral epicanthal areas of the subjects. Skin barrier function was evaluated and skin replicas were molded on both epicanthal areas every 4 weeks. The changes of the skin wrinkles were analyzed with skin visiometer. Results: In comparison of the changes between groups treated with placebo and Ascidian tunic, there was statistically significant differences in hydration and sebum secretion. But there were no statistically significant differences in the result of R-value by visiometer. Conclusion: The treatment of Ascidian tunic extract seems to be partially effective in improving wrinkles, but further study is required. (Korean J Dermatol 2008;46(7):896~902)
사춘기 및 성인 아토피피부염 환자에서 스탬프형 배지를 이용한 황색 포도알균의 정량적인 배양
성현철 ( Hyun Chul Sung ),정홍대 ( Hong Dae Jung ),박경덕 ( Kyung Duck Park ),이원주 ( Weon Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.7
Background: The stratum corneum of the skin of patients with atopic dermatitis (AD) is highly susceptible to colonization by various bacteria, including Staphylococcus (S.) aureus. Because the frequency of bacterial colonization is significantly higher, skin barrier function against bacterial invasion appears to be significantly disrupted in AD. S. aureus colonization in AD is thought to be important in the development and aggravation of eczematous skin lesions. Over the past decades, there have been several quantitative methods of cutaneous bacterial culture from the skin; the swab method, scrub method, tape method and contact plate method. Objective: The purpose of this study was to evaluate the effectiveness of the contact-plate sampling technique as a quantitative culture method of S. aureus in atopic dermatitis. Method: The subjects were 24 patients with AD and 24 age-matched normal controls. S. aureus was sampled at 4 evaluation sites (neck forearm abdomen, popliteal fossa) of AD patients and normal controls using the contact-plate sampling technique. We also checked skin barrier function by measuring the transepidermal water loss (TEWL). Results: Based on the data, we found that the number of S. aureus colonies in the samples from AD patients was significantly higher than from normal controls (p<0.05, 4 sites respectively). Also, TEWL at the 4 evaluation sites of AD patients was significantly higher than in normal controls (p<0.05, 4 sites respectively). However, S. aureus colonization did not usually show significant correlation with TEWL. Conclusion: The contact-plate sampling technique provides a reliable qualitative and quantitative culture method of S. aureus, which is inexpensive and convenient so can be used in both children and within a busy clinic. (Korean J Dermatol 2007;47(7):673∼679)
김효진 ( Hyo Jin Kim ),성현철 ( Hyun Chul Sung ),이석종 ( Seok Jong Lee ),이원주 ( Weon Ju Lee ),나건연 ( Gun Yoen Na ),김도원 ( Do Won Kim ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.5
Congenital triangular alopecia has been reported as a rare form of focal hair loss, characterized by a triangular patch of permanant alopecia on the frontoparietal area of the scalp, present from birth. However, it shows diverse clinical spectra of onset, shape and location and, furthermore, it may not be as rare as previously thought. Therefore, in order to avoid inappropriate management, it is very important to differentiate it from preclinical nevoid entities such as epidermal nevus, aplasia cutis and, especially, alopecia areata. We herein report five cases of congenital triangular alopecia. (Korean J Dermatol 2006;44(5):597~600)
백반증 환자의 각질형성세포와 멜라닌세포에 대한 타크롤리무스의 영향
김효진 ( Hyo Jin Kim ),성현철 ( Hyun Chul Sung ),박경덕 ( Kyung Duck Park ),나건연 ( Gun Yoen Na ),이원주 ( Weon Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ) 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.6
Background: Vitiligo is caused by the destruction of melanocytes, however the precise mechanism is still not known. Recently, abnormalities of both humoral and cell-mediated immunity have been documented in patients with this disorder, thus providing a theoretical basis for introducing tacrolimus ointment which works as an immunomodulator in the treatment of vitiligo. Objective: This study was undertaken to examine the effects of tacrolimus on the survival rates of keratinocytes and melanocytes in vitiligo patients, as well as the melanization of melanocytes. Methods: Keratinocytes and melanocytes from the normal skin of 4 vitiligo patients were cultured. They were then treated with various concentrations of tacrolimus (0.01, 0.1, 1, 10, 100μM) for 5 days. Thereafter, MTT (3-(4,5-cimethylthiazol-2-yl)-2,5-di-phenyl tetrazolium bromide) assay and melanin content analysis were performed. Results: Tacrolimus showed no significant effect on the survival rates of keratinocytes. However, a mild proliferative effect on melanocytes was observed at 10μM concentration. On the other hand, marked cytotoxicity was observed at higher than 100μM concentration, and there was no effect under 1μM concentration. The melanin content of individual melanocytes were decreased in proportion to the concentration. Conclusion: These findings indicate that tacrolimus does not have a proliferative effect on keratinocytes and melanocytes in vitiligo patients, and has a tendency to decrease the melanin content in the melanocytes. (Korean J Dermatol 2006;44(6):708~713)
이원주 ( Weon Ju Lee ),성현철 ( Hyun Chul Sung ),박경덕 ( Kyung Duck Park ),전재복 ( Jae Bok Jun ),서순봉 ( Soon Bong Suh ),방용준 ( Young Jun Bang ),최종수 ( Jong Soo Choi ) 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.10
Background: Otomycosis is a mycotic disease of the external auditory meatus. Aspergillus is the most common pathogen. Despite the fact that a great number of fungi are considered as the cause of otomycosis, otomycosis due to dermatophytes occurs with great rarity. Objective: The purpose of this study was to investigate clinical and mycological features of dermatophytosis in the external auditory meatus. Methods: We performed a clinical and mycologic analysis of 17 patients who had been clinically and mycologically diagnosed with dermatophytosis of the external auditory meatus. In addition, amplication of TRS-1 and TRS-2 of the ribosomal DNA nontranscribed spacer was performed on strains of Trichophyton (T.) rubrum and T. raubitshcekii which were isolated from skin lesions of the external ear and cerumen in 6 patients. Results: The ratio of male to female patients was 1.4:1. The age of patients were 6 to 72 and mean age of onset is 36.4. Eleven patients had concomitant dermatophytosis of other sites. Tinea unguium was combined in 7 cases, tinea pedis in 4 cases, tinea corporis in 3 cases, tinea manus in 2 cases and tinea cruris in 1 case. The positive rate of KOH examination was 88.2% and the positive rate of fungal culture on PDAC media was 88.2%. The most common organism cultured was T. rubrum (80.0%), followed by T. raubitschekii (13.3%) and T. mentagrophytes (7.7%). Ten patients were treated with topical terbinafine and seven patients with oral itraconazole, so all patients were cleared of fungi from the external auditory meatus and inflammation was resolved. With TRS-1 and TRS-2 amplication, 4 of 5 pairs of T. rubrum and 3 strains of T. raubitshcekii showed the same types regardless of the site in each patient. Conclusion: Dermatophytosis occurs rarely in the external auditory meatus but we experienced 17 cases of dermatophytosis at this site. With suspected otomycosis, dermatophytosis of the external auditory meatus and concomitant dermatophytosis must be investigated and treated simultaneously to prevent any recurrence. (Korean J Dermatol 2006;44(10):1171~1177)