http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Infliximab으로 치유된 치료저항성 괴저고름피부증
정홍대 ( Hong Dae Jung ),지성근 ( Seong Geun Chi ),김병수 ( Byung Soo Kim ),이원주 ( Weon Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.3
Pyoderma gangrenosum is an uncommon, neutrophilic, ulcerating, chronic dermatosis with obscure etiology. Many therapeutic modalities have been used in the past, but they have not always provided favorable outcomes. Recently, tumor necrosis factor-α inhibitors have been gaining attention in the treatment of recalcitrant pyoderma gangrenosum. A 57-year-old woman presented with painful, recurrent erythematous nodules and ulcers on both legs. She had been treated with systemic steroids, immunosuppressants, dapsone, and colchicine, and she experienced improvement with systemic steroids only. After using infliximab (5 mg/kg), she experienced dramatic improvement in her lesions. Thus, we report a recalcitrant case of pyoderma gangrenosum that was successfully treated with infliximab. (Korean J Dermatol 2009;47(3):343∼346)
사마귀양혈관종과 혈관각화종: 임상병리조직학적 유사점과 차이점
정홍대 ( Hong Dae Jung ),박경덕 ( Kyung Duck Park ),지성근 ( Seong Geun Chi ),이석종 ( Seok Jong Lee ),최윤석 ( Yoon Seok Choe ),김병수 ( Byung Soo Kim ),김도원 ( Do Won Kim ),정호윤 ( Ho Yun Chung ),윤길숙 ( Ghil Suk Yoon ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.4
Background: Verrucous hemangioma (VH) and angiokeratoma (AK) are vascular birthmarks of an unclear nosology and these birthmarks commonly show a superficial hyperkeratotic vascular component. There are both similarilities and differences between VH and AK with some confusion concerning their overlapping features. Objective: This study was undertaken to review the clinicopathological features of VHs and AKs and to determine the similarilities and differences between them. Methods: We retrospectively reviewed 11 VHs and 7 AKs at the Vascular Anomaly Clinic of our hospital over the past 10 years. They were evaluated from the clinicopathologic point of view for factors such as the age of onset, location, size, symptoms, the histopathological epithelial change and involvement of deeper tissue. Results: These birthmarks share common clinical features with the exception of gender and lesion size. Histopathologically, hyperkeratosis, acanthosis and capillary dilatation in the upper dermis were commonly seen. Yet lobular proliferation and dilatation of blood vessels in the deep dermis, or more importantly, the subcutis were detected in VH only. Furthermore there was a case of VH that showed diffusely scattered increased blood vessels in the subcutis, suggesting an evolving stage of VH and there was another case of VH that was erroneously diagnosed as AK via the initial biopsy, and the final diagnosis was changed according to the excised lesion. Conclusion: The two diseases share most of their clinicopathological features, but small parts of features like gender, the clinical size and the histological deep dermis/subcutis involvement were differences. Making the correct differential diagnosis between VH and AK through a deep biopsy with appropriate timing and long term follow up and/or radiological examination is helpful to avoid erroneous management. (Korean J Dermatol 2009;47(4):419~424)
장기간 전신 스테로이드제 사용 중인 피부질환자에서 고관절 방사선 촬영의 의의
정홍대 ( Hong Dae Jung ),김병수 ( Byung Soo Kim ),이원주 ( Weon Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.1
Background: Systemic corticosteroid is one of the most common drugs used in dermatology departments. However, physicians are well aware that there are quite a number of side effects from systemic corticosteroid. One of them, avascular necrosis of femoral head, has been frequently documented in association with systemic corticosteroid. Objective: The aim of this study was to evaluate the clinical usefulness of hip x-rays to ascertain the presence of avascular necrosis of the femoral head in patients who have used or are using systemic corticosteroid for a long period of time. Methods: A total of 151 patients who were using systemic corticosteroid and who underwent hip x-ray at our university hospital from December 2004 to July 2007 were enrolled in this study. We reviewed the patients` charts to determine the existence of abnormal results on hip and chest x-rays and also other side effects of corticosteroid, and we wanted to calculate the dosage of corticosteroid that had been used by these patients. Results: Out of the 151 patients who underwent hip x-ray, 5 patients had avascular necrosis of the femoral head, but only 3 patients` cases (2%) were involved with corticosteroid. Three patients showed old tuberculosis findings when they underwent chest x-ray. Among the other side effects of corticosteroid, weight gain side effect was the most common and 14 patients experienced this. Conclusion: This study demonstrates that those patients who use systemic corticosteroids for a long period of time for the treatment of chronic dermatologic disease are advised to undergo regular hip x-rays to screen for avascular necrosis of the femoral head. (Korean J Dermatol 2009;47(1):12~17)
Acquired Digital Arteriovenous Malformation 7예
정홍대 ( Hong Dae Jung ),지성근 ( Seong Geun Chi ),이석종 ( Seok Jong Lee ),김병수 ( Byung Soo Kim ),이원주 ( Weon Ju Lee ),김도원 ( Do Won Kim ),정호윤 ( Ho Yun Chung ),배한익 ( Han Ik Bae ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.2
Acquired digital arteriovenous malformation (ADAVM) consists of an abnormal connection between the arteriole and venule in the acral area of extremities, particularly the fingers. Clinically, the lesions appear as small, slightly-elevated, dark brown erythematous macules on the distal part of fingers. The histological specimens shows close approximation between thin-walled venule and thick-walled arteriole and possibly a direct arteriovenous shunt adjacent to each other lying in the dermis. We herein report seven stereotypical cases of ADAVM. (Korean J Dermatol 2009;47(2):203∼207)
사춘기 및 성인 아토피피부염 환자에서 스탬프형 배지를 이용한 황색 포도알균의 정량적인 배양
성현철 ( Hyun Chul Sung ),정홍대 ( Hong Dae Jung ),박경덕 ( Kyung Duck Park ),이원주 ( Weon Ju Lee ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.7
Background: The stratum corneum of the skin of patients with atopic dermatitis (AD) is highly susceptible to colonization by various bacteria, including Staphylococcus (S.) aureus. Because the frequency of bacterial colonization is significantly higher, skin barrier function against bacterial invasion appears to be significantly disrupted in AD. S. aureus colonization in AD is thought to be important in the development and aggravation of eczematous skin lesions. Over the past decades, there have been several quantitative methods of cutaneous bacterial culture from the skin; the swab method, scrub method, tape method and contact plate method. Objective: The purpose of this study was to evaluate the effectiveness of the contact-plate sampling technique as a quantitative culture method of S. aureus in atopic dermatitis. Method: The subjects were 24 patients with AD and 24 age-matched normal controls. S. aureus was sampled at 4 evaluation sites (neck forearm abdomen, popliteal fossa) of AD patients and normal controls using the contact-plate sampling technique. We also checked skin barrier function by measuring the transepidermal water loss (TEWL). Results: Based on the data, we found that the number of S. aureus colonies in the samples from AD patients was significantly higher than from normal controls (p<0.05, 4 sites respectively). Also, TEWL at the 4 evaluation sites of AD patients was significantly higher than in normal controls (p<0.05, 4 sites respectively). However, S. aureus colonization did not usually show significant correlation with TEWL. Conclusion: The contact-plate sampling technique provides a reliable qualitative and quantitative culture method of S. aureus, which is inexpensive and convenient so can be used in both children and within a busy clinic. (Korean J Dermatol 2007;47(7):673∼679)
Capillary Aneurysm 4예 -흑색종과의 임상적 감별진단-
지성근 ( Seong Geun Chi ),정홍대 ( Hong Dae Jung ),이석종 ( Seok Jong Lee ),김병수 ( Byung Soo Kim ),이원주 ( Weon Ju Lee ),김도원 ( Do Won Kim ),윤길숙 ( Ghil Suk Yoon ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.12
Capillary aneurysm is classically described as a suddenly growing dark papule, and is also known as thrombosed capillary or vein. It is clinically significant that the clinical features of capillary aneurysm are closely similar to those of malignant melanoma or dysplastic nevus. The histopathological finding of capillary aneurysm reveals dilated thin-walled venule(s) just beneath the hyperplastic epidermis, lined by a single layer of endothelium and a thrombus in the lumen. This abstract focuses on four patients who presented with a dark black-colored dome-shaped nodule and clinical impression included malignant melanoma, dysplastic nevus, angiokeratoma and lymphangioma circum-scriptum. We herein report four cases histologically diagnosed as capillary aneurysm, which should be considered for differential diagnosis. (Korean J Dermatol 2007;45(12):1265∼1269)
유아혈관종의 임상병리조직학적 고찰: GLUT-1염색의 진단적 유용성
지성근 ( Seong Geun Chi ),정홍대 ( Hong Dae Jung ),이석종 ( Seok Jong Lee ),김병수 ( Byung Soo Kim ),이원주 ( Weon Ju Lee ),김도원 ( Do Won Kim ),정호윤 ( Ho Yun Chung ),윤길숙 ( Ghil Suk Yoon ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.4
Background: Hemangioma of infancy (HOI) is one of the most common tumors in childhood. Their clinical features can on occasion look like those of other vascular tumors and malformations, so the correct differentiation of HOI may not always be easy. Objective: The purpose of this study was to review the clinicopathological features of HOIs and to particularlyexamine the usefulness of glucose transporter protein isoform-1 (GLUT-1) immunohistochemical stain (IHS) as a specific marker of HOI. Methods: This study was conducted at the Vascular Anomaly Clinic of Kyungpook National University Hospital during 11 years (1998~2008). Sixty-two cases were selected in addition to selecting other tumors and malformation as a control group. We then reviewed their clinical features and the results of H&E and GLUT-1 IHS for making the differential diagnosis.Results: The male to female ratio was 1: 2.88. The head and neck were the most commonly involved sites. The complications included ulceration and/or bleeding (12.9%), scarring (9.7%), infection (4.8%), ocular complications (4.8%) like visual axis occlusion, and pain (1.6%). Three phases of proliferating, involuting and involuted of a HOI comprised 11.3%, 37.1% and 51.6% of the lesions, respectively, from the clinical view point and 11.3%, 48.4% and 40.3% of the lesions, respectively, from the pathological point of view. GLUT-1 was positively expressed on almost all of the HOIs (47/57, 82.5%), except for 10 HOIs of the involuted phase and the other controls. Conclusion: The clinicopathological findings of this study were similar with those of the previous reports. The expression of GLUT-1 by a HOI can be helpful to make the correct diagnosis from other vascular tumors and malformations. (Korean J Dermatol 2009;47(4):386~394)
박경덕 ( Kyung Duck Park ),정홍대 ( Hong Dae Jung ),이석종 ( Seok Jong Lee ),김병수 ( Byung Soo Kim ),이원주 ( Weon Ju Lee ),김도원 ( Do Won Kim ),서보익 ( Bo Ik Suh ),정호윤 ( Ho Yun Chung ),배한익 ( Han Ik Bae ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.12
Cutaneous angiosarcoma is a rare, aggressive vascular malignancy with a grave prognosis. It usually arises in the scalp or face as a locally-advanced patch, plaque or tumor at presentation and most often affects males and the elderly. Histopathologically, well-differentiated angiosarcomas are composed of well- or ill-formed vascular channels, often lined by flattened atypical endothelial cells and are distinguished from benign counterparts by their so-called collagen dissection pattern and anastomosing architecture. Varied differentiation may be observed even in the same tumor. Epithelioid angiosarcoma is a rare variant of poorly-differentiated angiosarcoma. The patients were seven cases of angiosarcomas including an epithelioid variant. They were six males and one female with an age range between 65∼84 years (avg. 74 years). Lesions resembled seborrheic dermatitis, erysipelas or spreading bruise that varied from blue to red in color and from papule to mass in size. They revealed satellite lesions far from the main lesion in some cases. Skin biopsies were performed for all patients and histopathologic features were compatible with angiosarcoma and epithelioid angiosarcoma. We herein report seven angiosarcomas of diverse clinical features because their early detection and precise differential diagnosis should be mandatory for effective management. (Korean J Dermatol 2007;45(12):1284∼1290)
박경덕 ( Kyung Duck Park ),정홍대 ( Hong Dae Jung ),이원주 ( Weon Ju Lee ),나건연 ( Gun Yoen Na ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.11
Norwegian scabies can be defined as a generalized, severe scabies infestation which usually affects immunocompromised patients. The diagnosis is commonly missed, and can lead to mismanagement. We describe a patient with Norwegian scabies affecting the whole body. The patient had suffered with pemphigus foliaceus for several years and had an immunosuppressed status due to long-term use of oral corticosteroids. He was admitted to our hospital. At first, we made a diagnosis of exfoliative dermatitis secondary to pemphigus foliaceus. However, no improvement of the condition was seen after an increased dosage of oral corticosteroids, azathioprine, and mycophenolate mofetil. We then identified adult scabietic mites, eggs and scybala upon microscopic examination of skin scales. He was treated with an application of gamma benzene hexachloride cream. We recommend that the diagnosis of scabies be considered in immunocompromised patients with thick skin scales and associated night pruritus. (Korean J Dermatol 2006;44(11):1345~1348)
Nasalis Island Pedicle Flap을 이용한 코 하부의 결손부 재건
지성근 ( Seong Geun Chi ),정홍대 ( Hong Dae Jung ),이석종 ( Seok Jong Lee ),최윤석 ( Yoon Seok Choe ),김병수 ( Byung Soo Kim ),김도원 ( Do Won Kim ),박병철 ( Byung Cheol Park ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.12
Reconstruction of surgical defects of the nose, particularly the lower one third, is often challenging. The skin of this area is less mobile and fixed on lower structures without a subcutaneous fatty layer. Thus, dissection of tissues is rather difficult and more bleeding can occur during dissection. Furthermore, flap surgery will fail if the flap extends too far. Local flap surgery is one of the more useful techniques that maintains the function and aesthetics of a normal nose. Among these, the nasalis muscle is relatively easy and provides better outcomes. More importantly, vascular supplies from the underlying muscular structure provide greater viability. Additional movement can be achieved by either dissecting under the transverse nasalis or by dividing the transverse nasalis beyond the midline. We report 5 cases of nasalis island pedicle flaps using nasalis muscles. The final results were relatively satisfactory for both functional and cosmetic aspects. (Korean J Dermatol 2008;46(12):1634∼1639)