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목과(木瓜), 호장근(虎杖根) 및 유향(乳香) 추출물이 Raw 264.7 cell에서 LPS로 유도된 nitric oxide 생성에 미치는 영향
이태진,우경진,서성일,신상우,김상찬,권영규,박종욱,권택규,Lee, Tae-Jin,Woo, Kyung-Jin,Shu, Seong-Il,Shin, Sang-Woo,Kim, Sang-Chan,Kwon, Young-Kyu,Park, Jong-Wook,Kwon, Taeg-Kyu 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.6
In activated macrophage, large amounts of nitric oxide (NO) are generated by inducible nitric oxide synthase (iNOS), resulting in acute or chronic inflammatory disorders. In Raw 264.7 cells stimulated with lipopolysaccharide (LPS) to mimic inflammation, water extracts from the fruit of Chaenomeles sinensis, the root of Polygonum cuspidatum and Boswellia carterii inhibited the LPS-induced NO production in a parallel dose-dependent manner. To investigate the mechanism by which those extracts inhibits NO production, we examined the expression of iNOS and COX-2 in both mRNA and protein levels. We observed a significant change in the iNOS expression between LPS alone and LPS plus those extracts-treated cells. However, water extracts from Chaenomeles sinensis, Polygonum cuspidatum and Boswellia carterii did not inhibit COX-2 expression which was induced by LPS treatment in Raw 264.7 cells. These data suggest that water extracts from Chaenomeles sinensis, Polygonum cuspidatum and Boswellia carterii can modulate anti-inflammatory immune response, which may be in part associated with the regulation of NO synthesis through the regulation of iNOS expression in mouse macrophage cells.