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- 저자 : 서기석 ( Seo Gi Seog ) (검색결과 2 건)
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김승희 ( Kim Seung Hui ),전영승 ( Jeon Yeong Seung ),심형준 ( Sim Hyeong Jun ),서기석 ( Seo Gi Seog ),김상태 ( Kim Sang Tae ) 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.3
N/A Background: The incidence of metastatic skin cancer has been reported to be relatively low. Because the diagnosis is not so difficult, cutaneous metastasis could be an important clue to discover the hidden internal malignancy, if found before recognizing primary cancer, or play a significant role to determine therapeutical plans and prognosis if found after diagnosis of primary cancer. Material and methods: This study was made upon the 68 cases of metastatic skin cancer, which had been confirmed histopathologically in the department of dermatology, Kosin University Gospel hospital from January, 1986 to August, 2003. Age and sex distributions, sites of primary cancer, time of detection, localization of the lesions, morphologic and histopathologic findings were examined by the review of medical records, clinical photographs, and pathologic slides. Results: 1. The mean age at the time of diagnosis was 56.6 years and most patients were distributed over 5 decades. The male to female ratio was 1:1.3. 2. Metastasis from breast carcinoma consisted of 19 cases, this was the most common primary cancer, followed by lung cancer, melanoma, and stomach cancer. In men, lung cancer and stomach cancer were the most common primary neoplasm, while breast cancer was the most frequent in women. 3. 50 of the cases were detected after diagnosis of primary cancer and during therapy. The other 18 cases were detected before the internal malignancy was recognized. 4. The localization of metastatic skin cancer was widespread over the whole body. The majority of cutaneous metastasis was predisposed to the surface near primary cancer, but distant metastases 5. The most common morphologic features were single or multiple nodules, while inflammatory and indurated plaques were also found. 6. Histopathologic examination revealed that adenocarcinoma was the most common pathologic type, followed by squamous cell carcinoma and melanoma. The histopathologic features of cutaneous metastasis generally mimicked that of primary tumors. Conclusion: Generally, metastatic skin cancer is detected after the diagnosis of primary cancer showing subsequent treatment failure and poor prognosis. In some cases, however, cutaneous metastasis can be the earliest sign to recognize internal malignancy. Especially in the cases of metastatic skin cancer originating from the kidney, liver and thyroid gland, cutaneous features are the most significant evidences to presume the site of origin without any other findings. Therefore, it is important to recognize the clinical and histopathologic findings of metastatic skin cancer for the most successful diagnostic, therapeutic and prognostic determination. (Korean J Dermatol 2004;42(3):300~308)
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원발성 피부 CD30 양성 대형세포 림프종 8예에 대한 임상 및 조직학적 관찰
김유찬 ( Kim Yu Chan ),이민걸 ( Lee Min Geol ),박상건 ( Park Sang Geon ),양우익 ( Yang U Ig ),서기석 ( Seo Gi Seog ) 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.11
N/A Background : Although several cases of primary cutaneous CD3O-positive large cell lymphoma have been reported, immunohistochemical study on the tumor has not been reported in Korea. Objective : Our purpose is to evaluate the clinicopathologic and immunohistochemical findings of primary cutaneous CD3O-positive large cell lymphoma. Methods : An immunohistochemical study was performed on paraffin sections of 8 primary cutaneous CD3O-positive large cell lymphoma using CD3, CD45RO, CD45, CD2O, CD3O, and epithelial membrane antigen(EMA). Results : 1. Primary cutaneous CD3O-positive large cell lymphoma occurred equally on males and females. The average age of the patients was 49. The lesion occurred most commonly as nodules on the extremities. Spontaneous regression occurred in 3 cases. The most common treatment was radiotherapy. 2. Histopathologically, 2 of 8 cases showed epidermal hyperplasia with intraepidermal neutrophils. Epidermotropism was found focally in 1 case. Inflammatory cells were present at the periphery of the lesions in 2 cases, but they were admixed with the large atypical cells in 1 case. Tumor cells invaded the subcutaneous tissue in 4 of 6 cases. 3. Immunohistochemically, the large anaplastic cells showed CD3O positivity. Tumor cells in all cases showed positivity for CD3, CD45RO, and CD45, but negative for CD2O. Tumor cells stained with EMA in 1 of 6 cases. Conclusion : Primary cutaneous CD3O-positive large cell lymphoma showed immunophenotype of T-cell lymphoma. It showed some clinicopathologic features of lymphomatoid papulosis, which suggests that both entities represent 2 ends(malignant and benign) of a spectrum of CD3O-positive lymphoproliferative disorders. Therefore, for the diagnosis of primary cutaneous CD3O-positive large cell lymphoma, all clinicopathologic and immunohistochemical findings should be considered together. (Korean J Dermatol 2003;41(11) : 1471∼1477)
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