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Increased expression of ICAM-3 is associated with radiation resistance in cervical cancer
배덕수 ( Duk Soo Bae ),( Young Min Chung ),( Byoung Gie Kim ),( Chang Soo Park ),( Seung Jae Huh ),( Jhin Gook Kim ),( Jong Kuk Park ),( Sun Mi Cho ),( Byung Soo Kim ),( Jun Suk Kim ),( Young Do Yoo ) 대한산부인과학회 2006 대한산부인과학회 학술대회 Vol.92 No.-
임신 중 자궁 근세포 내에서 cytokine들이 matrix metalloproteinase-9 을 발현시키는 신호전달체계에 관한 연구
서용수(Yong Soo Seo),백금희(Geum Hee Baek),허지희(Ji Hee Heo),양순하(Soon Ha Yang),김종화(Jong Hwa Kim),배덕수(Duk Soo Bae),노정래(Cheong Rae Roh) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
N/A Objective : To explore the intracellular signal transduction pathways of IL-1β and TNF-α in inducing matrix metalloproteinase-9 (MMP-9) in human myometrial smooth muscle cells. Methods : We studied the expression of MMP-9 induced by cytokines (TNF-α and IL-1β) with zymography. The influence of TNF-α and IL-1β on the phosphorylation of Jun N-terminal kinase (JNK) and IkB were studied with immunoblotting for p-JNK and p-IkB. The intranuclear shifting of NF-kB and AP-1 after treatment with TNF-α and IL-1β were evaluated by EMSA. Results : TNF-α- and IL-1β-induced MMP-9 expression was not suppressed by NF-kB inhibitor (CAPE), AP-1 inhibitor (curcumin) and PKC inhibitor (calphostin C) but was inhibited by tyrosine kinase inhibitor (genistein). After treatment of myometrial smooth muscle cells with TNF-α and IL-1β, phosphorylation of JNK and phosphorylation of IkB with degradation of IkB were evidently observed. The intranuclear translocations of NF-kB and AP-1 were strongly enhanced after treatment with TNF-α and IL-1β as demonstrated in EMSA. Conclusion : In myometrial smooth muscle cells, MMP-9 is induced by TNF-α and IL-1β through PKC activation and transcriptional activations of NF-kB and AP-1. Independent of PKC activation, the signaling of TNF-α and IL-1β in the induction of MMP-9 seems to be transmitted by way of either NF-kB or AP-1 activation in myometrial smooth muscle cells.
최세미(Se Mi Choi),박창수(Chang Soo Park),오성희(Sung Hee Oh),김태중(Tae Joong Kim),송상용(Sang Young Song),안긍환(Geung Hwan Ahn),배덕수(Duk Soo Bae),이제호(Je Ho Lee) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.1
Hepatoid carcinoma is a rare type of malignant tumor resembling hepatocellular carcinoma that arises in extrahepatic sites.(stomach, lung, ovary, pancreas, bladder and renal pelvis). Hepatoid carcinoma of the ovary is an extremely rare ovarian tumor, first described by Ishikura and Scully in 1987. Histologically it is important to differentiate this entity from other oxyphil tumors of the ovary as it requires aggressive treatment. We have experienced a case of hepatoid carcinoma of the ovary in 69-year-old postmenopausal woman, who has been treated with operation and adjuvant Taxol - cisplatin chemotherapy. We present this case with brief review of literatures.
노재홍(Jae Hong Noh),박창수(Chang Soo Park),김병기(Byoung Gie Kim),이제호(Je Ho Lee),배덕수(Duk Soo Bae),오상윤(Sang Yun Oh),최철훈(Chel Hun Choi),이유영(Ui Young Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.10
Struma Ovarii is a teratoma with thyroid tissue as the predominant (>50%) constituent. It is rare, representing about 2% of all teratomas, and its malignant transformation, less than 5% of struma ovarii. Presenting symptoms are not specific, therefore pre-operative diagnosis of malignant struma ovarii is difficult and most diagnosis of malignant struma ovaii is determined by post-operative histologic findings. Because of the rarity of malignant struma ovarii, there is considerable confusion concerning diagnosis and management. A postmenopausal woman presented with pelvic mass and lower abdominal pain and explo-laparotomy was performed. Then, pathologic report was identified as malignant struma ovarii. We report a case of malignant struma ovarii with brief review of literature
황종대(Jong Dae Whang),박창수(Chang Soo Park),배덕수(Duk Soo Bae),이제호(Je Ho Lee),노정수(Jeong Soo Noh),김정식(Jeong Sik Kim),주인숙(In Sook Joo) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.1
Extraperitoneal inguinal endometriosis often presents as an inguinal mass in women of reproductive age, Approximately 40 cases of inguinal endometriosis have been documented in the sutgical and gynecological literature. The overall incidence is in the range of 0.4% of patients with endometriosis. The right side is much more commonly involved than the left (almost 90% of the time in one series of 23 patients), and rarely is the condition bilateral. The most frequent complaint of patients with inguinal endometriosis is an inguinal mass, followed by pain and enlargement of the mass near menstruation. Authors have experienced two cases of endometriosis of the extraperitoneal portion of the round ligament of uterus and report with a brief literature review.
자궁내막암 환자의 임상병리학적 예후인자에 따른 생존율 분석
노재홍(Jae Hong Noh),이지수(Ji Soo Lee),이용승(Yong Seung Lee),이수호(Soo Ho Lee),최중섭(Joong Sub Choi),김영아(Young A Kim),박창수(Chang Soo Park),김병기(Byoung Gie Kim),이제호(Je Ho Lee),배덕수(Duk Soo Bae) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.10
목적 : 자궁내막암 환자의 임상병리학적 양상을 확인하고 예후인자에 따른 생존율을 분석하고자 하였다. 연구 방법 : 1995년 1월부터 2001년 12월까지 삼성서울병원에서 자궁내막암으로 진단 및 치료받은 111의 환자를 대상으로 하였다. 환자들의 의무기록을 통하여 연령, FIGO 수술적 병기, 세포 유형, 종양의 크기, 세포분화도, 자궁근층 침윤정도, 그리고 림프절 전이를 확인하였으며, 환자의 생존 여부는 마지막 병원 방문과 전화 연락을 통하여 조사하여 각각의 예후인자에 따른 생존율을 구하였다. 결과 : 자궁내막암의 중앙 연령은 52세였으며, 연령별 분포는 21세부터 79세까지였다. 임상 병기별 분포는 Ⅰ기가 84예 (82.0%), Ⅱ기가 16예 (8.1%), Ⅲ기가 10예 (9.0%), Ⅳ기가 1예 (0.9%)였다. 치료 방법은 전체 환자 111명 모두 수술적 치료가 시행되었으며, 수술 후 방사선 치료 60예 (54.1%), 수술 후 항암요법 5예 (4.5%)에서 시행되었다. 세포분화도 1이 73예 (65.7%), 2가 19예 (17.1%), 3이 14예 (12.6%)로 나타났으며, 침윤정도는 자궁내막에만 국한되어 있었던 경우가 37예 (33.3%), 1/2 이하인 경우가 47예 (42.3%), 1/2 이상이 26예 (24.3%)를 나타냈고, 림프절 전이는 6예 (5.4%)가 있었다. 전체 자궁내막암 환자 111예의 5년 무병생존울은 86.5%, 5년 생존율은 87.8%였다. FIGO 수술적 병기에 따른 무병 생존율 및 5년 생존율은 각각 제 1기가 92.8%, 93.3%, 제 2기가 80.0%, 80.0%, 제 3기가 57.1%, 85.7%였으며, 그 외에 발생연령, 림프-혈관 침범 유무, 자궁근층의 침범 정도, 림프절 전이 유무, 그리고 C-erb-B2 발현 여부가 생존율에 영향을 미치는 예후 인자였다. 그러나 수술 전 CA-125상승, 자궁경부 세포진 검사 결과, 에스트로겐 수용체나 프로제스테론 수용체의 유무, p53 유전자 유무는 생존율에 통계적으로 유의한 영향을 미치지 않았다. FIGO 병기 제 Ib기와 제Ic기에서 보조적 방사선 치료를 시행한 군은 재발 위험 인자를 가진 군이라는 것을 고려한다면 비슷한 생존율을 나타낸 것은 수술 후 방사선 치료가 재발 방지에 효과적일 수 있다는 가능성을 제시한다고 할 수 있겠다. 결론 : 이상의 결과에서 FIGO 수술적 병기, 세포분화도, 자궁근층 침범정도, 림프-혈관 침범 유무, 림프절 전이, 연령, C-erb-B2의 발현은 자궁내막암 환자에 미치는 유사한 인자라고 추정되었다. Objective : This study was performed to evaluate the clinicopathologic characteristics and prognostic factors of uterine endometrial cancer affecting survival of the patients. Methods : Form Jan. 1995 to Dec. 2001, medical records including operation record and pathologic reports of 111 patients with histologically proven endometrial cancer at Samsung Medical Center were reviewed. The survival of patients was determined by description of last follow up date in medical records or phone calls. Results : The median age of all patients was 52 years and the most common presenting symptom was abnormal vaginal bleeding (74.0%). Histologic type of endometrioid adenocarcinoma was the most common (90%) type of all endometrial cancers. The grades were classified into G1 (65.7%), G2 (17.1%), G3 (12.6%) and unknown (4.5%). The FIGO surgical stage was also classified into stage I (75.7%), stage Ⅱ (14.4%), stage Ⅲ (9.0%), and stage Ⅳ (0.9%). All patients were treated by primary surgery and postoperative adjuvant therapy including radiation therapy (54.1%), chemotherapy (4.5%) was applied. The overall 5-year disease free survival rate (DFSR) was 86.5% and overall 5-year survival rate was 87.8%. The age (p=0.04), grade (p=0.04), myometrial invasion (p=0.047), FIGO surgical stage (p=0.0067), lymph node metastasis (p=0.0001), lymphovascular space invasion (p=0.01) and C-erb B2 (p=0.04) were significant prognostic factors by univariate analysis. Conclusion : The age, grade, myometrial invasion, FIGO surgical stage, lymph node metastasis, lymphovascular space invasion and C-erb B2 were significant prognostic factors of uterine endometrial cancer affecting survival of the patients.
상피성 난소암 환자에서 생존율 분석을 통한 임상병리학적 예후 인자에 대한 고찰
최중섭(Joong Sub Choi),박창수(Chang Soo Park),김병기(Byoung Gie Kim),이제호(Je Ho Lee),배덕수(Duk Soo Bae),김우영(Woo Young Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.10
목적 : 본원에 내원한 상피성 난소암 환자의 임상병리학적 특징과 이러한 인자들의 예후 인자로서의 효용성에 대한 가치를 알아보고자 하였다. 연구 대상 및 방법 : 1995년 1월부터 2000년 12월까지 삼성서울병원 산부인과에서 상피성 난소암으로 치료받은 147명의 환자를 대상으로 하였다. 임상병리학적 특징을 포함한 의무기록을 후향적으로 조사하였다. 생존율은 Kaplan-Meier 방법에 의해서 산출하였으며 생존 곡선간의 비교는 log-rank 방법을 이용하였다. 각각의 임상병리학적 인자들에 대한 다변량 분석은 Cox proportional hazard model을 이용하였다. 결과 : 상피성 난소암 환자의 조직학적 분류에 따른 빈도를 보면 다음과 같았다. 장액성 난소암 57.1%, 점액성 난소암 15.0%, 자궁내막양 난소암 15.0%, 투명세포암 9.5%, 혼합성 3.4%이었다. 147명 전체 환자의 FIGO 수술적 병기별 분포는 다음과 같았다. 제 1기: 29.3%, 제 2기: 4.1%, 제 3기: 54.4%, 제 4기: 12.2%. 수술 전 혈중 CA-125의 조직학적 분류에 따른 평균 역치는 장액성이 2,715 mIU/ml (S.E.637), 자궁내막양이 2,002 mIU/ml (S.E.687), 혼합성이 896 mIU/ml (S.E.290), 점액성이 421 mIU/ml (S.E.145), 투명 세포암이 236 mIU/ml (S.E.140) 이었다. 일차 수술 후 67명 (48.9%)에서는 잔류 종양이 없었으며, 16명 (11.7%)에서는 2 ㎝ 미만의 잔류 종양이 남았고, 54명 (39.4%)에서는 2 ㎝ 이상의 잔류 양이 남았다. 전체 환자의 5년 생존율은 46.7%로 나타났으며, 단변량 분석에서는 FIGO stage (p=0.0091), 세포분화도 (p=0.0081), 잔류종괴 용적 (p=0.0038), 조직학적 유형 (p=0.0313)이 통계적으로 유의하였으나 다변량 분석에서는 FIGO 수술적 병기 (p=0.048)만이 통계적으로 유의함을 보였다. 결론 : 이상의 결과에서 본원에 내원한 상피성 난소암 환자의 생존율에 영향을 미치는 가장 중요한 예후인자는 진단 당시 FIGO 수술적 병기인 것으로 확인되었다. Objective : In this retrospective study, we analyzed the clinicopathologic characteristics of epithelial ovarian cancer and evluated the prognostic factors which has an impact on survival of the patients with epithelial ovarian cancer. Patients and Methods : Total 147 patients with epithelial ovarian cancer who were treated at Samsung Medical Center between 1995 and 2000 were included. Medical records including pathologic reports were reviewed to identify clinicopathologic characteristics. Survival was analyzed by Kaplan-Meier method and log-rank test was used for curve comparison. Cox proportional hazards model was used for multivariate analysis. Results : The histopathologic distribution of all the patients was as follows: serous type (57.1%), mucinous type (15.0%), endometrioid type (15.0%), clear cell type (9.5%). mixed type (3.4%). The FIGO stage distribution for invasive epithelial ovarian cancer was stage I (29.3%), stage Ⅱ (4.1%), stage Ⅲ (54.4%), and stage Ⅳ (12.2%). The mean value of pre-operative CA-125 according to histologic type was 2715 IU/ml (S.E. 637) for serous type, 2002 IU/ml (S.E. 687) for endometrioid type, 896 IU/ml (S.E. 290) for mixed type, 421 IU/ml (S.E. 145) for mucinous type, and 236 IU/ml (S.E. 140) for clear cell ovarian cancer. No residual tumor was identified in 67 patients (48.9%) after primary cytoreductive surgery. Sixteen patients (11.7%) exhibited less than 2 ㎝ tumor and 54 patients (39.4%) 2 ㎝ or more macroscopic residual tumor. Second-look laparotomy was undertaken and pathologic residual disease was observed in 12 cases out of 39 (30.7%) patients. The overall 5-year survival rate of all the patients was 46.7%. In univariate analysis, FIGO stage (p=0.0091), grade (p=0.0081), residual volume (p=0.0038) and histologic type (p=0.0313) were significant prognostic factors affecting survival. However, multivariate analysis demonstrated that only FIGO stage (p=0.0048) was identified as a significant independent prognostic factor in this study. Conclusion : This study showed that FIGO stage was identified as a significant independent prognostic factor in the patients with epithelial ovarian cancer of all stages.