광범위한 분포를 보인 보웬양 구진증

박향준 ( Hyang Joon Park ),김송 ( Song Kim ),김원석 ( Won Serk Kim ),양준모 ( Jun Mo Yang ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.10

Bowenoid papulosis (BP) is largely a disease of young, sexually active adults, which presents with pink or flesh colored macular or papular lesions in the anogenital area. It has been established that various human papilloma virus (HPV) types are the causative agents of BP and of these, HPV-16, the oncogenic one, is the most common. The course of BP is variable, ranging from spontaneous regression to persistent of lesions to a transformation into squamous cell carcinoma. We report a case of Bowenoid papulosis in a 29-year-old, sexually active female whose anogenital area was covered with innumerable papular lesions extended to the lower extremities. (Korean J Dermatol 2007;45(10):1052∼1054)

기저세포암과 편평세포암에서 bcl-2 및 involucrin의 발현에 관한 연구

김유찬 ( Kim Yu Chan ),박향준 ( Park Hyang Jun ),신용우 ( Sin Yong U ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.11

N/A Background : The histologic distinction between basal cell carcinoma(BCC) and squamous cell carcinoma(SCC) is sometimes difficult, but cinically important because the risk of progressive disease is significaltly higher with SCC than BCC. Objective : The purpose was to investigate the usefulness of bcl-2 and involucrin staining in distinguishing BCC from SCC. Methods : We studied 10 cases of BCC and 10 cases of SCC with monoclonal antibodies for bcl-2 and involucrin. Results : Five of 10 cases of BCC stained with bcl-2, but none of SCC stained. Only 2 of 10 cases of BCC stained weakly with involucrin, but all 10 cases of SCC stained moderately or strongly. Conclusion : A panel of antibodies for bcl-2 and involucrin may be useful in distinguishing BCC from SCC. We might speculate that involucrin is a more useful marker because it is moderately to strongly positive for all cases of SCC while weakly positive for only 2 of 10 cases of BCC. (Korean J Dermatol 2003;41(11) : 1494-1499)

Tongue Flap을 이용하여 치료한 아랫입술의 편평세포암

박지혜 ( Ji Hye Park ),박혜영 ( Hae Young Park ),김초록 ( Cho Rok Kim ),신현태 ( Hyun Tae Shin ),박향준 ( Hyang Joon Park ),이동윤 ( Dong Youn Lee ),이주흥 ( Joo Heung Lee ),양준모 ( Jun Mo Yang ),이일수 ( El Soo Lee ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.7

The lips have important functional and esthetic facial features and the lips are used for relatively simple tasks, such as retaining oral contents, as well as for complex functions such as mastication, speech and expressing emotion. Therefore, it is esthetically and functionally critical to maintain the normal position and contour of the lips during reconstructive surgery. However, the freely movable nature of the vermilion and the cutaneous lip makes this area highly susceptible to distortion. We report here on a case of squamous cell carcinoma on the lower lip and the extensive surgical defect that resulted from total vermilionectomy and wedge resection of the lip was repaired with the tongue flap. (Korean J Dermatol 2010;48(7):620∼623)

산소분압과 발생부위에 따른 켈로이드 배양섬유모세포의 혈관내피 성장인자(VEGF) 발현

문형식 ( Hyung Sik Moon ),손숙자 ( Sook Ja Son ),박건 ( Kun Park ),강희규 ( Hee Gyoo Kang ),임희정 ( Hee Joung Lim ),박향준 ( Hyang Jun Park ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.5

Background: The pathophysiological events resulting in keloid formation remain unclear. Overabundant levels of VEGF have been reported to contribute to excessive wound healing. There have been many studies describing the relationship between keloids and VEGF expression. However, there have been no reports about VEGF expression related to donor sites. Objective: We investigated VEGF expression of cultured normal and keloid fibroblasts obtained from different body areas under normoxic and hypoxic culture conditions. Methods: Normal fibroblasts from the earlobe (n=2), shoulder (n=2) and chest (n=2) as well as keloid fibroblasts from the earlobe (n=3), shoulder (n=3) and chest (n=3) were collected and cultured. VEGF expression of fibroblasts at 6 hours, 12 hours, 24 hours and 48 hours for cells maintained under normoxic and hypoxic conditions was measured by the use of RT-PCR. Paraffin-embedded tissues (normal and keloid tissue) were assayed by immunohistochemical staining. Results: For the cultured normal fibroblasts, VEGF expression for cells in the hypoxic condition was higher as compared to VEGF expression in cells in the normoxic condition, irrespective of the donor site and time. However, for the cultured keloid fibroblasts, VEGF expression for cells in the hypoxic condition was higher as compared to VEGF expression in cells in the normoxic condition for cultured shoulder fibroblasts. For each donor site, VEGF expression was highest in the shoulder, followed by the chest and earlobe for cultured normal fibroblasts, irrespective of time. For the cultured keloid fibroblasts, the highest VEGF expression occurred at 6 hours for cells in the normoxic condition and the highest VEGF expression occurred at 6 hours and 12 hours for cells in the hypoxic condition. Based on immunohistochemical staining, VEGF expression of paraffin-embedded normal tissue was lower as compared to paraffin-embedded keloid tissue. For each donor site in paraffin-embedded keloid tissue, VEGF expression was highest in the shoulder, followed by the chest and earlobe. Conclusion: Oxygen tension and the nature of fibroblasts from different donor sites are involved in keloid pathogenesis. (Korean J Dermatol 2009;47(5):539~546)

피지선 모반과 동반된 이차 종양

노윤우 ( No Yun U ),이증훈 ( Lee Jeung Hun ),박장규 ( Park Jang Gyu ),김유찬 ( Kim Yu Chan ),박향준 ( Park Hyang Jun ),신용우 ( Sin Yong U ),윤태영 ( Yun Tae Yeong ) 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.10

N/A Background : Frequent association of nevus sebaceus with other skin appendage tumors and with apocrine glands suggests that the nevus sebaceus may be derived from the primary epithelial germ. Syringocystadenoma papilliferum was found most frequently in the nevus sebaceus. A number of cases have been reported, but extensive studies on the secondary tumors of nevus sebaceus are rare in Korea. Objectives : The purpose of this study was to investigate characteristic clinical features in Korean patients with the secondary tumors of nevus sebaceus. Materials & Methods : Enrolled were total 136 patients confirmed as nevus sebceus at the Chungnam National University Hospital, the Dankook University Hospital, and the Chungbuk National University Hospital from March 1993 to February 2003 for this study. And we reviewed the Korean Journal of Dermatology and the Annals of Dermatology for nevus sebaceus with secondary tumors. Result : The results were as follows : 1. Total 45 cases were included from 23 males and 22 females. The male/female ratio was similar. Trichoblastoma(86% in female) and basal cell carcinoma(67% in female) were more frequent in female than in male. 2. Mean age was 38.7 years(range 1.5 years to 71 years). all malignant tumors except basal cell carcinoma developed beyond 40 years of age. 3. In the malignant tumors, 19(95%) or 20 cases developed in the scalp. However, in the benign tumors, 44(86.3%) of 51 cases developed in the scalp and 7(13.7%) of 51 cases in the face. 4. Tumors of one type developed in 29 cases and tumors of more than two types developed in 16 cases. 5. The total seventy eight tumors were composed of 23 malignant tumors and 55 benign tumors. Basal cell carcinoma and syringocystadenoma papilliferum were the most common tumor in each group respectively. Although trichoblastoma was not counted as the most common tumor, we suggest that it might be the most frequent tumor in secondary tumors associated with nevus sebaceus because differential diagnosis between trichoblastoma and basal cell carcinoma was so difficult that many cases of trichoblastoma were misdiagnosed as basal cell carcinoma.(Korean J Dermaton 2003;41(10) : 1338~1346)

집게손발톱의 수술적 치료 효과에 대한 연구

문형식 ( Hyung Sik Moon ),손숙자 ( Sook Ja Son ),박건 ( Kun Park ),박향준 ( Hyang Jun Park ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.5

Background: A pincer nail deformity is characterized by the presence of an excessively curved and distorted nail across the transverse dimension, particularly at the distal part of the nail plate. A multitude of therapeutic modalities has been implemented to treat this condition with limited efficacy. Objective: We sought to evaluate the efficacy of surgery of a pincer nail deformity with the use of the modified Haneke`s method. Methods: Six patients (seven toenails and two fingernails) with pincer nail deformities were treated with the modified Haneke`s method. Objective assessment was evaluated by use of the width index (width of the nail tip/width of the nail root) and height index (height of the nail tip/width of the nail root). Subjective assessment was evaluated by use of a visual analogue scale declared by patients. In addition, wound complications and recurrence were described. Results: The width index and height index were improved (width index: 15.4%→7.1%, height index: 63.9%→1.9%). Relief of pain could be determined in 100% of the cases. For subjective assessment, all of the patients were satisfactory (more than satisfactory: 100%). There was no recurrence during a 14 to 24 month period (mean time: 19.2 months). Conclusion: The modified Haneke`s method as a surgical approach might be effective and the procedure is easy to perform for a pincer nail deformity. (Korean J Dermatol 2009;47(5):509~515)

단순포진 바이러스 및 수두대상포진 바이러스 감염의 감별진단을 위한 면역조직화학적 검사

심상대 ( Sim Sang Dae ),김유찬 ( Kim Yu Chan ),박향준 ( Park Hyang Jun ),신용우 ( Sin Yong U ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.1

N/A Background: The clinical distinction between herpes simplex virus (HSV) and varicella-zoster virus(VZV) skin infections is sometimes difficult. Potentially, immunohistochemical method can distinguish HSV from VZV infection. However, immunohistochemical studies for the differentiation beetween them have rarely been reported. Objective: The purpose is to investigate the usefulness of immunohistochemical staining in differentiation between HSV and VZV infections. Methods: We studied 9 cases of herpes zoster, 4 cases of chicken pox, and 5 cases of herpes simplex with monclonal antibody to VZV. Routine histopathologic findings of the cases were also evaluated. Results: All cases of VZV infections staines with antibody to VZV, but none of HSV infection stained. In VZV infection, 2.5% of cases showed strong or diffuse positive reaction, whereas the rest of them showd weak or focal pattern. Histopathologically, the degree of inflammation was significantly greater in HSV infection than in VZV infection. However, vaculitis was more frequently found in VZV infection than in HSV infection. Conclusion: We think immunohistochemistry with antibody to VZV is very useful in the differen-tiation between HSV and VZV infections, even if the reaction pattern may be so weak of focal, as careful interpetation is necessary. (Korean J Dermatol 2004;42(1):47~52)

음경에 발생한 전이성 위암

김지혜 ( Ji Hye Kim ),최지현 ( Ji Hyun Choi ),김준범 ( June Bum Kim ),김학주 ( Hak Ju Kim ),박향준 ( Hyang Joon Park ),이재승 ( Jae Seung Lee ),조옥자 ( Ok Ja Joh ),송계용 ( Kye Yong Song ),최준정 ( Jun Jeong Choi ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.4

Metastatic carcinoma of the penis is rare and in most cases is associated with primary malignancy of the pelvic organs with widespread metastasis. A 64-year-old man presented with a 2 month history of skin-colored papules on his penis. He also had a history of total gastrectomy and chemotherapy due to advanced gastric carcinoma. Skin biopsy from the lesion revealed atypical polygonal cells with hyperchromatic & pleomorphic nuclei in the dermis. Results of immunohistochemical staining showed a positive reaction of CK7, and a negative reaction of CK20, PSA, and CD68. We report herein a case of metastatic cancer of the penis from gastric carcinoma. (Korean J Dermatol 2010;48(4):306~309)

피부 자궁내막 증식증 1 예

신용우,김유찬,송원근,박향준 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.7

Endometriosis is defined as the growth of endometrial tissue outside the uterine cavity and its occurrence is usually related anatomically to the uterus and its attachments. Cutaneous endometriosis occurs most commonly as a secondary process in scars after abdominal or pelvic procedures including hysterotomy, hysterectomy, cesarean section, episiotomy, and laparoscopy. Because of the rarity of cutaneous endometriosis, and the failure of the recognition of the correlation between the intensity of the pain and the menstrual cycle, the diagnosis can be easily missed. We present a case of cutaneous endometriosis occurred in the scar of a previous cesarean section in a 27-year-old woman.