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최준식,유재신,박용채,이진환 朝鮮大學校 1997 藥學硏究誌 Vol.18 No.2
This study was attempted to investigate the pharmacokinetic interaction between sodium valproate (4. 8. 16 ㎎/㎏. i.v.) and phenytoin (4 ㎎/㎏. i.v) in rabbits. The plasma concentration and area under the curve (AUC) of phenytoin were increased significantly (p<0.05. p<0.01) when coadministered with sodium valproate (4. 8. 16 ㎎/㎏) in rabbits. The volume of distribution and total body clearance of phenytoin were decreased significantly (p<0.05. p<0.01) when coadministered with sodium valproate (8. 16 ㎎/㎏) in rabbit. From the results of this experiment. it is desirable that dosage regimen of phenytoin should be adjusted and therapeutic drug monitoring should be performed for reduction of side or toxic effect when phenytoin will be coadministered with sodium valproate in clinical use.
최준식,유재신,박용채,인진환 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.2
This study was attempted to investigate the pharmacokinetic interaction between sodium valproate (4, 8, 16 ㎎/㎏, i.v.) and phenytoin (4 ㎎/㎏, i.v.) in rabbits. The plasma concentration and area under the curve (AUC) of phenytoin were increased significantly (p<0.05, p<0.01) when coadministered with sodium valproate (4, 8, 16 ㎎/㎏g) in rabbits. The volume of distribution and total body clearance of phenytoin were decreased significantly (p<0.05, p<0.01) when coadministered with sodium valproate (8, 16 ㎎/㎏) in rabbit. From the results of this experiment, it is desirable that dosage regimen of phenytoin should be adjusted and therapeutic drug monitoring should be performed for reduction of side or toxic effect when phenytoin will be coadministered with sodium valproate in clinical use.