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박기호 한국디지털정책학회 2011 디지털융복합연구 Vol.9 No.1
Ultimately, this research will focus on the activity traits of future customers in the convergence age. To accomplish that, firstly, researcher develop measures for assessing the convergence level of digital devices and digital services. Next, this will investigate the behavioral traits of people who use specific devices or services on the internet or mobile networks. This study proposed five convergence measures each for devices and services. For digital devices, measures such as converged functions, accessibility to network, portability, immediate communicability, and expandibility of functions were utilized. For digital services, measures such as scope of users, newness, social network level, ease-of-use on mobile networks, and expandibility of information were used. We believe that the research results can provide insights for those wishing to explore the convergence level of devices and services and those developing high-level converged devices and digital services.
폐외결핵 환자에서의 치료에 따른 연속적인 T-SPOT.TB 검사
박기호,조오현,고광범,이유미,박현정,박소연,문송미,정용필,이상오,최상호,김양수,우준희,김성한 대한감염학회 2011 Infection and Chemotherapy Vol.43 No.3
Background: Limited data are available for the clinical utility of serial interferongamma producing T-cell response after initiation of treatment in patients with extrapulmonary tuberculosis (TB). We studied the serial TB-specific antigen T-cell responses measured using the T-SPOT.TB assay during the course of therapy. Material and Methods: We prospectively enrolled adult patients who were newly diagnosed with active extrapulmonary TB over a 24-month period. All patients were given standard anti-TB treatment. Blood samples were obtained for T-SPOT.TB at diagnosis, as well as 1-, 3-, 6-, and 12-months after initiating anti-TB therapy. Results: A total of 52 patients with extrapulmonary TB (38 confirmed and 14 probable TB) were included in the final analysis. All patients had clinical and radiologic improvement after treatment and cured. T-SPOT.TB was positive for 90% at diagnosis, 100% at 1-, 3-, and 6-months, and 93% at 12-months after initiation of anti-TB therapy. There was no significant difference in median T-cell response between early secreting antigenic target-6 (ESAT-6) and culture filtrate protein-10 (CFP-10) at all time points. Median T-cell response steadily increased up to 6 months and then decreased. Conclusions: T-SPOT.TB assay remained positive after successful anti-TB treatment in most patients with extrapulmonary TB. Our data suggests that serial T-SPOT.TB has limited clinical utility as a surrogate marker of treatment response in patients with extrapulmonary TB.