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우리나라에서 분리된 풍진바이러스의 염기서열 분석 및 유전자 발현
송진원(Jin Won Song),김태환(Tae Hwan Kim),김종헌(Jong Hun Kim),박광숙(Gwang Sook Park),이용주(Yong Joo Lee),백락주(Rak Joo Baek),송기준(Ki Joon Song) 대한바이러스학회 2000 Journal of Bacteriology and Virology Vol.30 No.1
During the recent epidemic period (1995-1996), seven strains of rubella virus were isolated in Korea. To analyze phylogenetic relationship between seven Korean strains and rubella virus strains from other different geographical areas, structural genes (El, E2 and C) of Korean strains were enzymatically amplified and automatically sequenced. The sequence similarities of the E1, E2 and C genes of the cosmopolitan types were 95.8 98.1%, 92.6 99.2% and 96.4-99.3% based on 1,441, 122 and 139 nucleotides and 96.9-98.5%, 90-100% and 97.8-100% based on 480, 40 and 46 amino acids compared to the sequences of strain RA27/3, respectively. In contrast, the sequence similarities of the E1, E2 and C genes of the Asian types were 91.5-92.1%, 83.6-88.5% and 91.4% based on nucleotides and 96.9-97.7%, 85.5% and 97.8% based on amino acids compared to the sequences of strain RA27/3, respectively. However, immunodominent epitopes of the E1 gene of the cosmopolitan and Asian types were well conserved, and the growth patterns in cell culture and immunofluorescent antibody titers in cross-reaction test showed no differences between two different types. In phylogenetic analysis based on nucleotide sequences of each gene regions, the cosmopolitan and Asian types formed two distinct phylogenetic lineages, These data showed two distinct genotypes of rubella viruses cocirculated in Korea, but no significant differences in the antigenicity of two different rubella virus strains were found.
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흰넓적다리붉은쥐 유래 한타바이러스 분리 및 분자생물학적 특성 비교
송기준(Ki Joon Song),윤형선(Hyung Sun Yoon),고은영(Eun Young Ko),정기모(Gee Mo Jung),박광숙(Gwang Sook Park),이용주(Yong Joo Lee),송진원(Jin Won Song),백락주(Rak Joo Baek) 대한바이러스학회 2000 Journal of Bacteriology and Virology Vol.30 No.1
Two distinct hantaviruses have been isolated from Apodemus agrarius in 1976 and Rattus norvegicus in 1980 in Korea. Since our serosurveys conducted in 1994, a genetically distinct hantavirus from Apodemus peninsulae has been investigated. To isolate hantavirus from A. peninsulae captured in Korea, the lung homogenate of seropositive A. peninsulae inoculated Vero E6 cells. Viral antigen was detected in a progressively higher percentage of cells with subsequent passage after 80 days postinoculation. The new isolate from seropositive Apodemus peninsulae was designated Suchong virus after Suchong valley located in northeastern region of South Korea. Comparing with hantaan virus 76-118 strain, Suchong virus-1, 2, 3 and 4 showed the similarity of 71.0-91.8% at nucleotide and 90.9-94.8% at amino acid sequences in 231 nucleotides region of M segment, and the similarity of 75.1-81.0% at nucleotide and 97.5-100% at amino acid sequences in 237 nucleotides of S segment.
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