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만성 골수성 백형병에 있어서 Busulfan 과 Hydroxyurea 의 치료 효과의 비교
이규보,황기석,류만준,구본환 대한내과학회 1986 대한내과학회지 Vol.31 No.4
A retrospective analysis of 27 patients with chronic myelogenous leukemia treated with busulfan(20 patients) and hydroxyurea(7 patients) was done in order to compare .the effectiveness of each therapeutic modality. In the busulfan-treated group the white blood cell count decreased to normal in all the patients, anemia improved in 88.9%, and splenomegaly decreased or disappeared in 85.0%. In the hydroxyurea-treated group, the decrease of white blood cell count to normal, correction of anemia, and disappearance of splenomegaly were observed in all the patients treated. The order of recovery in the busulfan-treated group was the normalization of the white blood cell count, correction of anemia, and disappearance of splenomegaly, while the hydroxyureatreated group showed the normalization of white blood cell count, disappearance of splenomegaly, and correction of anemia. The treatment with hydroxyurea demonstrated a more rapid decreasing effect on the white blood cell count than did busulfan. On the other hand, the fluctuations of the white blood cell count in the hydroxyurea-treated group were so remarkable that frequent adjustments to dosage were necessary to maintain the sustained control of the cell count. The adverse effects of busulfan were skin pigmentation(100%) and pancytopenia(10%), whereas in the hydroxyurea-treated group mild nausea. and vomiting were noted in only 3cases(43%).
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