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사람 피부섬유아세포에서 안토시아닌(덱스트린이 결합된 시아니딘)의 항산화활성
노빛나,박원봉 서울여자대학교 자연과학연구소 2011 자연과학연구논문집 Vol.23 No.-
Antioxidant activity of anthocyanin (dextrin-conjugated cyanidin) from Acanthopanax divaricatus var. albeofructus (ADA) fruits was investigated in human dermal fibroblast cells. As a result, the generation of H2O2 and lipid peroxide induced by UVA-irradiation in HDF-N cells was reduced by treatment of anthocyanin. In addition, enhanced enzyme activity was observed in cells treated with anthocyanin in both superoxide dismutase (SOD) and catalase (CAT) reduced by UVA irradiation. In conclusion, the results show that the anthocyanin from ADA fruits could be potential candidates for the protection of fibroblast against the damaging effects of UVA irradiation and for development of source of antioxidant agent. Key words:UVA, fibroblast, Acanthopanax, anthocyanin, antioxidant, lipid peroxidation, SOD, CAT.
노빛나,전명숙 서울여자대학교 자연과학연구소 2007 자연과학연구논문집 Vol.19 No.-
Water extracts of Acanthopanax divaricatus var. albeofructus root were used to treat hPBMC (human peripheral blood mononuclear cells) to determine the mechanism for the immunomodulatory effects. The secretion level of various cytokines including Th-1 type (IL-2, L-12, IFN-γ and TNF-α) and Th-2 type (IL-6, IL-4 and IL-10) were measured using ELISA. A significant increase of Th-l type cytokine secretion was observed in the presence of extract while Th-2 cytokine, IL-6 was suppressed. Our results suggest that Acanthopanax divaricatus var. albeofructus root extract may influence the anticancer immune responses towards a predominance of Th-l cytokines in the immune system.
사람 말초혈액 단핵세포에서 흰털오가피 열매 추출물에 의한 Th1/Th2 Cytokine 분비조절
유수연,노빛나,박원봉,Lyu, Su-Yun,Noh, Bin-Na,Park, Won-Bong 대한약학회 2008 약학회지 Vol.52 No.1
Water extracts of Acanthopanax divaricatus var. albeofructus (ADA) fruits were used to treat hPBMC to determine the mechanisms for the immunomodulatory effects. The secretion level of various cytokines including Th-1 type (IL-2, L-12, $IFN-{\gamma}$ and $TNF-{\alpha}$) and Th-2 type (IL-6, IL-8 and IL-10) were measured using ELISA. A significant increase of Th-1 type cytokine secretion was observed in the presence of extract while Th-2 cytokine, IL-6 was suppressed. Our results suggest that ADA fruit extract may influence the anticancer immune responses towards a predominance of Th-1 cytokines in the immune system.
자외선이 조사된 사람피부 섬유아세포에서 흰털오가피 잎추출물의 항산화작용
신애향,유수연,노빛나,김자인,김옥경,박원봉,Shin, Ai-Hyang,Lyu, Su-Yun,Noh, Bin-Na,Kim, Ja-In,Kim, Ok-Kyoung,Park, Won-Bong 대한약학회 2007 약학회지 Vol.51 No.4
We investigated antioxidative activity of the water and ethanol extracts of leaves of Acanthopanax divaricatus var. albeofructus in human dermal fibroblast (HDFs) irradiated by UVA. The irradiation of UVA did not affect the cell viability of HDFs. The antioxidative activity of the extract was investigated by xylenol orange, TBARS (thiobarbituric acid reactive substances) and antioxidant enzyme assay. Both extracts showed H202 scavenging activity and inhibited lipid peroxidation in HDF cells irradiated by UVA. The extracts also recovered enzyme activity in the same cells.
유수연(Su-Yun Lyu),김지영(Ji-Young Kim),노빛나(Binna Noh),박원봉(Won-Bong Park) 대한약학회 2006 약학회지 Vol.50 No.3
Acanthopanax species have traditionally been used as a tonic, a sedative as well as in the treatment of rhcumatism, hypertension and diabetes. In the present study, oxidative stress was induced in Vero cells by incubating the cells with glucose and the cell viability was measured by MTT assay. The concentration of glucose which 50% of cell viability was 125 mM (IC50) and the cell viability was increased to 87.6±8.8% by treatment of the extracts of Acanthopanax divar- icatus var. albeofructus. The antioxidative activity of water extract of different parts of the Acanthopanax plant was investigated by DPPH (1,1-diphenyl-2-picrylhydrazyl) assay, xylenol orange assay, TBARS (thiobarbituric acid reactive substances) assay and enzyme (superoxide anion and catalase) assay. Each extract (leaves, root, stem and fruits) of the plant showde free radical and H2O2 scavenging activity. The extract also inhibited lipid peroxidation and recovered enzyme(superoxide anion dismutase and catalase) activity in Vero cells treated with glucose.