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NAM, KOONG YONG,KIM, YUNG JIN,PARK, KYUNG SOOK,KIM, HYUN SUP,AHN, KWANG SOOK,HONG, SEUNG HO,LEE, CHUNG CHOO 충남대학교 기초과학연구소 1991 연구논문집 Vol.11 No.-
As a part of the investigation for clarifying the genetic composition of Korean population, phenotypes and allele frequencies of complement Factor I and complement Factor H in the blood were analysed by polyacrylamide gel isoelectric focusing followed by immunoblotting. Blood samples were obtained from healthy individuals living in Seoul, Kangreung an Cheju, Korea. Three phenotypes of complement Factor I (FI A, FI AB and FI B) appeared in Korean population. The allele frequencies of FI*A and FI*B were 0.9011 and 0.0989, respectively. Phenotypes of complement Factor H were classified into three common types(FH A, FH AB and FH B) and five rare types (FH A1, FH A1A, FH A1B, FH BM and FH QO). Allele frequencies of FH*A, FH*B, FH*A1, FH*M and FH*QO were 0.4739, 0.5056, 0.0155, 0.0024 and 0.0016, respectively. The FI*B frequency of Mongoloids was lower than that of Caucasoid population. The FH*B frequency appeared relatively higher than FH*A frequency in most populations studied. Rare alleles, FH*M and FH*QO, appeared in Korean and Japanese populations.
Regulation and Expression of α-Glycerol-3-phosphate Dehydrogenase(GPDH)in Drosophila melanogaster
Namkung, Yong,Kim, Se Jae,Lee, Chung Choo,Kim, Kyungjin 濟州大學校 基礎科學硏究所 1991 基礎科學硏究 Vol.4 No.1
노랑초파리의 α-glycerol-3-phosphate dehydrogenase(GPDH)의 발생단계 및 조직특이적 발현에 대한 발생유전학적 조절 양상을 연구하였다. 노랑초파리의 GPDH는 주로 흉부와 복부에서 각각 활성을 보이는 GPDH-1과 GPDH-3 의 두가지 동위효소로 이루어져 있는데, 성충에서 총 GPDH활성의 62%는 흉부에서 나타내며 복부에서는 총 GPDH활성의 약 32%를 보였다. 그러나 두 조직에서 GPDH의 상대적인 합성량은 서로 비슷하며 GPDH-3가 GPDH-1보다 훨씬 빨리 turnover됨을 암시하였다. 순수분리한 GPDH-1 으로 항혈청을 만든 후 두 동위효소의 면역학적인 동질성을 조사한 결과, 두 효소의 구조적인 차이는 매우 근소하였다. GPDH 동위효소의 기원을 규명하기 위해서 유충과 성체 조직으로 immunoblotting 과 in vitro translation을 수행한 바, 단백질 수준에서 GPDH-1의 단일체는 GPDH-3 의 단일체보다 분자량이 다소 큰 것으로 나타났다. 그러나 유충과 성체에서 추출한 RNA로 합성한 translation산물을 분석한 결과, 분자량이 동일한 하나의 band만 검출되는 것으로 보아 GPDH-3 는 GPDH-1에서 post translational modification 에 의해 생성되는 것으로 사료되었다. Several parameters of α-glycerol-3-pholphate dehydrogenase(GPDH)such as activity, content and translatable mRNA levels were measured to elucidate mechanism underlying developmental and tissue specific regulation of GPDH activity in Drosophila melanogaster. In adult segments, most of total GPDH activity(62%)was detected in thorax where GPDH-1 resided, while 32% of total GPDH activity was only detected in abdomen where GPDH-3 resided. The relative synthesis of GPDH was, however, similar in both tissues, although 58% of total GPDH was synthesis in abdomen. These results strongly suggest that the turnover rate of the abdominal enzyme(GPDH-3)was much more rapid than that of thoracic enzymes(GPDH-1). In vitro translation and immunoblotting experiments also indicate that GPDH-3 was arised by posttranslational modification from a single polypeptide(GPDH-1)
Namkung, Yong,Lee, Chung-Choo,Oh, Moon-You 제주대학교 1980 논문집 Vol.12 No.-
The polymorphism of the Group-Specific Component(Gc) was studied in serum samples from Jeju-do population of Korea using thin layered (1mm) polyacrylamide gel isoelectric focusing (PAGIF). Six common subtypes, 1F-1F, 1F-1S, 1S-1S, 1S-2, 1F-S and 2-2, were found. The allele frequencies were for Gc 1F;0.518, for 1S;0.312 and for Gc 2;0. 170, respectively. The heterogeneity rate was 0.5065.
이정주,남궁용 한국유전학회 1986 Genes & Genomics Vol.8 No.2
Polymorphisms of six red cell enzymes were studied on unrelated individuals from three areas (Seoul, Kangreung and Cheju) of Korea by horizontal starch gel electrophoresis. There were two G-6-PD alleles, GdB^+ and GdB^-, in Korean populations. The allele frequencies of GdB^+ in males were 0.9723 in Seoul, 0.9689 in Kangreung and 0.9726 in Cheju. Three soluble GOT alleles, GOT¹_s, GOT²_s and GOT³_s, were found in Korean populations. The allele frequencies of GOT¹_s were 0.9832 in Seoul, 0.9852 in Kangreung and 0.9851 in Cheju. It was interesting to note that GOT³_s allele was detected in Korean populations. The frequencies of GOT³_s were 0.0049 in Seoul and Kangreoung, and 0.0030 in Cheju. In esterase D study, two common alleles, EsD¹and EsD²were found. Allele frequencies of EsD¹were 0.6702 in Seoul, 0.6640 in Kangreung and 0.6716 in Cheju. There were two common acid phosphatase alleles, AcP^a and AcP^b, in Korean populations. AcP^c allele which was common in Caucasoids and rare alleles were not found. The allele frequencies of AcP^a were 0.3930 in Seoul, 0.4071 in Kangreung and 0.3826 in Cheju. In LDH and MDH studies, only the normal phenotype and no variant type were found. No variant type was found in both enzyme systems. So, LDH and cytoplasmic MDH seem to be monomorphic traits in Korean populations. The gene frequencies and polymorphic phenotypes of the above red cell enzymes were discussed in comparison with the other populations.