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장보현 ( Bo Hyun Jang ),김병욱 ( Byung Wook Kim ),임근준 ( Keun Joon Lim ),김부경 ( Boo Gyoung Kim ),박성민 ( Sung Min Park ),김준성 ( Joon Sung Kim ),지정선 ( Jeong Seon Ji ),최황 ( Hwang Choi ) 대한소화기학회 2015 대한소화기학회지 Vol.65 No.6
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Imatinib mesylate is recommended as adjuvant therapy for GIST after surgical resection. However, drug-related adverse events are common. A 74-year-old female with metastatic GIST who was managed with imatinib experienced severe adverse events, including skin rashes, tremor, and alopecia, etc. The imatinib dose was reduced and the size of the metastatic GIST continued to decrease and adverse events showed significant improvement. (Korean J Gastroenterol 2015;65:366-369)
Gemcitabine을 사용한 폐암환자에서 발생한 용혈성 요독증후군 1예
박윤정 ( Youn Jung Park ),양근석 ( Keun Suk Yang ),정홍순 ( Hong Soon Jung ),남희철 ( Hee Chul Nam ),정승혜 ( Seung Hye Jung ),김부경 ( Boo Gyoung Kim ),김가영 ( Ka Young Kim ),김정호 ( Jung Ho Kim ),김영옥 ( Young Ok Kim ),윤유선 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.2
Hemolytic uremic syndrome (HUS) is a rare disorder characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. HUS arises from a wide spectrum of conditions, and chemotherapeutic agents have been reported to be associated with HUS, including Mitomycin, Cisplatin, Bleomycin, and Gemcitabine. A 76-year-old man treated with Gemcitabine due to non-small cell lung cancer developed clinical and laboratory findings compatible with HUS. Gemcitabine was ceased and hemodialysis and plasma exchange were utilized and he recovered. A high level of suspicion for HUS is necessary when cancer patients are treated with Gemcitabine, and prompt recognition and treatment are also essential.