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췌담도 ; 알코올성 췌장염과 간경변환자에서 알코올 대사효소와 사이토카인의 유전자 다형성
김명식 ( Kim Myeong Sig ),정석 ( Jeong Seog ),이진우 ( Lee Jin U ),권계숙 ( Kwon Gye Sug ),이돈행 ( Lee Don Haeng ),김범수 ( Kim Beom Su ),김형길 ( Kim Hyeong Gil ),신용운 ( Sin Yong Un ),김영수 ( Kim Yeong Su ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 만성음주에 의한 장기의 손상의 개인적 감수성의 차이는 알코올 대사효소나 사이토카인의 유전자 다형성에 의해 영향을 받을 것으로 생각된다. 이 연구는 알코올성 췌장염과 알코올성 간경변 환자에서 알코올 탈수소효소2(ADH2), 알코올 탈수소효소3 (ADH3), 알데하이드 탈수소효소2 (ALDH2), 미소체 에탄올 산화계의 사이토크롬 P450 2E1효소(CYP2E1), 4가지 사이토카인(IL-1, IL-6, IL-8, TNF-α)들의 유전자의 유전자형
조기위암의 근치적 치료로서 내시경적 점막절제술의 유용성
현동효 ( Hyeon Dong Hyo ),정석 ( Jeong Seog ),이진우 ( Lee Jin U ),정봉주 ( Jeong Bong Ju ),류성태 ( Lyu Seong Tae ),이창근 ( Lee Chang Geun ),김명식 ( Kim Myeong Sig ),권계숙 ( Kwon Gye Sug ),이돈행 ( Lee Don Haeng ),김범수 ( Ki 대한소화기학회 2003 대한소화기학회지 Vol.42 No.6
Background/Aims: Endoscopic mucosal resection (EMR) has been widely accepted as a curative treatment of early gastric cancer (EGC). The aim of this study was to determine the usefulness and limitations of EMR for treatment of EGC by analyzing our own experience. Methods: We retrospectively evaluated 51 EGC lesions (45 mucosal and 6 submucosal cancers) from 49 patients who had undergone EMR between Oct. 1997 and Aug. 2002 at Inha Universtiy Hospital. Results: Among 45 lesions of mucosal cancer, enbloc resection was performed in 13 lesions and piecemeal resection in 32 lesions. Complete resection rates of enbloc and piecemeal resection were 84.6% and 43.8%, respectively (p=0.012). Complete resection rate of the lesions smaller than 1 cm in size was 71.4%, 1 to 2 cm in size 52%, and greazter than 2 cm in size 37.5%. Complete resection rates of well, moderately, and poorly differentiated EGC were 59.4%, 71.4%, and 16.7%, respectively (p=0.048). Thirty-three patients underwent a follow-up endoscopy at I month after EMR and two were found to have residual cancers. One patient who had a piecemeal EMR showed cerical and abdominal lymph node metastasis 10 months after EMR. Conclusions: In selected patients with EGC, EMR can be a curative treatment modality. However, complete resection rate is low in large sized and poorly differentiated EGCs and when piecemeal resection is performed. (Korean J Gastroenterol 2003;42:453-460)