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5% imiquimod 크림으로 치료한 소아의 첨규 콘딜롬 2예
고주연 ( Joo Youn Ko ),노영석 ( Young Suck Ro ),이창우 ( Chang Woo Lee ),김재홍 ( Jae Hong Kim ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.11
Condyloma acuminatum, an infection caused by human papilloma virus, is one of the most common sexually transmitted diseases involving the anogenital area. Although it has been more common in adults, the incidence in children has been increasing recently. Although several treatment options are available for condyloma in adults, children`s treatment options are limited because non-painful alternatives should be considered as first-line therapy. Imiquimod cream is an immunomodulating agent that has been demonstrated to be a potent inducer of several cytokines promoting an antiviral cell-mediated immune response. Herein, we report two cases of condyloma acuminata in children which showed an excellent response to 5% imiquimod cream without any adverse reactions.
Isotretinoin을 복용하는 여드름 환자에서 γ-Linolenic Acid 병용요법이 건조증 예방과 여드름 병변에 미치는 영향
정명길 ( Myeong Gil Jeong ),김정은 ( Jeong Eun Kim ),안지영 ( Ji Young Ahn ),고주연 ( Joo Yeon Ko ),박미연 ( Mi Youn Park ),노영석 ( Young Suck Ro ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.11
Background: Oral isotretinoin is an effective treatment modality for acne, but this agent may cause dryness of the skin and mucous membrane. Gamma-linolenic acid (GLA) has been known to improve skin moisture and reduce transepidermal water loss (TEWL). It is also known to have anti-inflammatory effects and to inhibit 5-alpha reductase. Objective: This study was performed to evaluate the clinical efficacy of GLA in the prevention of xerosis and improvement of acne lesions after concomitant administration of isotretinoin. Methods: In this prospective study, 102 Korean acne patients were enrolled and randomized to receive isotretinoin either with or without GLA for 12 weeks. Comparing evaluations included skin hydration, TEWL, visual analogue scale (VAS) score for dryness of the lips and skin, number of acne lesions such as comedos, papules, and pustules, Korean acne grading system (KAGS) grade, and patient satisfaction regarding treatment. Results: The decrease of skin hydration and increase of the TEWL of the lips and cheek were less definite in the experimental group than those of the control group. VAS score for dryness of the lips and skin was significantly lower in the experimental group compared with the control group. The number of acne lesions decreased in both groups; only the numbers of papules were different between the two groups. The decrease of the KAGS grade was more definite in the experimental group than that in the control group. Conclusion: This study suggests that GLA could be used effectively for the improvement of acne lesions as well as for the prevention of xerosis. (Korean J Dermatol 2013;51(11):863∼870)
탈색소 모반 및 혈관종과 동반된 다발성 밀크커피색 반점 1예
고주연,노영석,이창우,김재홍 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.10
When 6 or more cafe'-au-lait spots(CALS) tend to be randomly widely distributed, we must rule out neurofibromatosis(NF). Nevus depigmentosus is a congenital nonprogressive hypopigmented patch that shows histologically decreased pigmentation while CALS shows increased pigmentation. We report a case of a 16-month-aid girl showing generalized multiple cafe-au-lait spots with segmental nevus depigmentosus and capillary hemangioma on her right upper back. A possible explanation for the co-occurrence of CALS and nevus depigmentosus could be the concept of mosaicism.
고주연,노영석,김재홍 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.11
A drug eruption is any adverse skin reaction caused by a drug used in a normal dose. Celecoxib(Celebrexn^ ), a cyclooxygenase(COX) 2 inhibitor, is a new generation non-steroidal antiinflammatory drug, recently introduced in Korea. It is increasingly used because of significantly lower rate of gastrointestinal injury than typically seen with most other NSAIDs. Cutaneous reactions related to celecoxib are rare and there have been no previous reports in Korea. We report a case of drug eruption probably due to this drug with positive skin tests and wish to underline the possible cutaneous reactions with this new drug.