광범위한 첨규콘딜롬 치험 1예

정종재,황선욱,김석모 대한피부과학회 1999 大韓皮膚科學會誌 Vol.37 No.12

A 20 year old woman with noninsulin-dependent diabetes mellitus (NIDDM) developed an extensive warty and focally cauliflower like mass located at anogenital area. Its histopathologic study and in situ DNA hybridization revealed this lesion an ordinary condyloma acuminatum without large bulbous downward proliferation of which HPV type was 6 and/or 11. The mass lesion was successfully treated by excision and electrodesiccation under spinal anesthesia. Intermittent recurrence of several papular condylomata acuminata was observed during a follow up period of 6 months, which were easily cured by podophylline application on each occasion.

trans-[Co(Me-en)_2Cl_2]^+ 양이온의 수화반응에 미치는 압력과 온도의 영향

鄭倧在,崔相仁 慶北大學校 1984 論文集 Vol.38 No.-

The kinetics of the aquation for trans- [Co(Me-en]_2Cl_2]^+ cation was investigated by the electric conductivity method. The temperature range 35℃ to 50℃, and pressure was varied up to 2,000 bars. The rate constants increased with increasing temperature, but decreased with increasing pressure. The activation volume(ΔV^≠) decreased with increasing temperature and pressure. At 35℃ and 1 bar it was fairly small positive value, 4.13㎤/mole. The activation entropy (ΔS^≠) was found to be comparatively small negative value, -18.301 eu, at 35℃ and 1 bar. The results suggest that the aquation is proceeded by the interchange-dissociation (I_d) mechanism.

전이금속 착물의 전자구조 및 화학적 반응성(제1보) : cis-ML₄XY 형 착물의 광반응에 대한 리간드의 상대적 치환용이성 Relative Ligand Labilization in Photosubstitution Reactions of cis-ML₄XY Type Complexes

鄭倧在,崔鍾河,呂煥鎭 慶北大學校 1988 論文集 Vol.46 No.-

The most easily leaving ligand in the photosubstitution reactions of cis-ML_4XY type complexes (M = Cr(Ⅲ), Co(Ⅲ) : L = NH_3, CN, en/2; X, Y = unidentate) can be predicted by comparing of relative stability of several square pyramidal intermediates, where the energy levels of total stabilization and d-orbital for the intermediate are calculated by using the angular overlap method. According to the calculated results, the intermediate with larger total stabilization energy is, as expected, more easily produced. Therefore, the total stabilization energy of the primary intermediate is applied to determine which of ligand will be more susceptible to photolabilization.

N-(2-Hydroxyethyl)ethylenediamine-N, N', N'-triacetic acid를 配位子로한 Co(Ⅲ)錯物의 異性化反應速度

鄭倧在,金昌鎭,黃正儀 慶北大學校 1976 論文集 Vol.21 No.-

Two isomers of the [Co(H_2O)hedta] complex, equatorial geometry and polar geometry have been prepared, and their structures have been estimated by elemental analysis, infrared spectra, visible absorption spectra and kinetic study. The rate constants of the isomerization change between the polar isomer and the equatorial isomer were 2.12×10^-4 sec^-1 and 3.59×10^-5 sec^-1 at 60℃ in pure water and water-dimethylsulfoxide mixtures, respectively. The activation enthalpy ΔH^≠ is 16.8kcal/mole and the activation entropy ΔS^≠-25.4 e.u. in pure water, while in water-dimethlsulfoxide mixtures ΔH^≠is 26.4kcal/mole and ΔS^≠-0.24 e.u. No evidence of the isomerization from the equatorial geometry to the polar geometry can be obtained. The kinetic study suggested that the isomerization of the aqua complex proceed more rapidly in the pure water than in the water-dimethylsuloxide mixtures, and that the equatorial isomer is the more stable than the polar isomer.

수용액에서 〔Co(en)_3〕Cl_3 및 〔Co(NH_3)_6〕Cl_3 착물의 이온 해리에 미치는 압력의 영향

鄭倧在,盧炳吉 慶北大學校 物理化學硏究所 1986 硏究論文集 Vol.7 No.-

25℃에서 〔Co(en)_3〕Cl_3, 〔Co(NH_3)_6〕Cl_3 수용액의 열역학적 해리상수를 1∼2000bar의 압력범위에서 전도도법으로 측정하였다. 착물이 해리할 때 하전을 띤 이온이 생성하여 부피가 감소하므로 압력이 증가함에 따라 해리상수(K^T)는 커졌다. 즉 〔Co(en)_3〕Cl_3에 대한 _pK^T값은 1bar에서 2.16, 500bar에서 2.08, 1000bar에서 2.08, 1500bar에서 2.05, 2000bar에서는 2.03이었고, Co(NH_3)_6〕Cl_3의 _pK^T는 1bar에서 2.02, 500bar에서 1.96, 1000bar에서 1.90, 1500bar에서 1.88, 2000bar에서는 1.87이었다. 각 압력에서 Stokes반경과 해리상수(K_T)값을 비교 분석하여 착물의 이온쌍 형성에는 정전기적 인력 이외에 Internal Conjugate Base(ICB) 효과도 영향을 미쳤으며 이 효과는 압력이 증가할 수록 커졌다. The thermodynamic dissociation constants of 〔Co(en)_3〕Cl_3 and 〔Co(NH_3)_6〕Cl_3 in aqueous solutions at 25℃ and at the pressure from 1 bar to 2000 bars were measured by conductometric method. The dissociation constants were increased with pressure elevation because of volume decreasing by the formation of charged ions during dissociation reaction. That is, the _pK^T values of 〔Co(en)_3〕Cl_3 were 2.16 for 1 bar, 2.08 for 500 bars, 2,08 for 1000 bars, 2.05 for 1500 bars and 2.03 for 2000 bars, respectively and those of 〔Co(NH_3)_6〕Cl_3 were 2.02 for 1 bar, 1.96 for 500 bars, 1.90 for 1000 bars, 1.88 for 1500 bars and 1.87 for 2000 bars, respectively. Comparing and analyzing the values of Stokes' radii and K^T, the formation of ion pair compound was affected by not only the electrostatic interaction, but also the Internal Conjugate Base(ICB), which was incresed by the elevation of the pressure.

trans-[Cr$(en)_2Br_2]^+$ 및 trans-$[Cr(tn)_2Br_2]+^$ 착이온의 수화반응에 미치는 압력의 영향

정종재,박경석,Jong Jae Chung,Park Kyung Suk 대한화학회 1986 대한화학회지 Vol.30 No.4

전도도법을 이용하여 trans-[Cr$(en)_2Br_2]^+$ 와 trans-$[Cr(tn)_2Br_2]+^$의 수화반응에 대한 속도상수를 온도와 압력을 변화시키면서 측정했다. 이 때 수화반응의 속도상수는 온도가 증가함에 따라 증가했고 압력이 증가함에 따라 감소하는 경향을 보였다. 이 반응의 활성화부피는 모두 양의 값으로 그 범위는 trans-[Cr$(en)_2Br_2]^+$ 과 trans-$[Cr(tn)_2Br_2]+^$에 대해 각각 1.98~2.30 c$m^3$/mole 및 1.30 ∼ 1.92c$m^3$/mole 이었으며 활성화 엔트로피는 작은 음의 값을 가졌다. 이들 결과로 보아 이 착물들의 수화반응의 메카니즘은 $I_d$매카니즘인 것으로 추정된다. The rate for the aquation of trans-[Cr$(en)_2Br_2]^+$ and trans-$[Cr(tn)_2Br_2]+^$ ions in the aqueous solution has been measured by the conductometric method at various pressures and temperatures. The rate constants are increased with increasing temperature and decreased with increasing pressure. Activation volumes are all positive values and lie in the limited range +1.6 ∼ +2.3Oc$m^3$/mole for trans-[Cr$(en)_2Br_2]^+$ and +1.30 ∼ +1.92c$m^3$/mole for trans-$[Cr(tn)_2Br_2]+^$. Activation entropies have small negative values while activation compressibilities have small positive values. From the above results, we may deduce that the mechanism for the aquation of these complexes is the $I_d$ mechanism.

Chromium(III) 錯物의 光化學的 反應性

정종재,황정의,최종하,Jong-Jae Chung,Jung-Ui Hwang,Jong-Ha Choi 대한화학회 1986 대한화학회지 Vol.30 No.2

$trans-Cr^{Ⅲ}N_4XY$착물의 광화학적 치환반응에 있어서 한개의 리간드가 떨어져서 생기는 가상적 1차중간체의 총안정화에너지를 고려함으로서 치환되는 리간드를 예측할 수 있다. 총안정화 에너지와 d-궤도함수의 1전자에너지준위는 각종첩모형체계내에서 계산하였는데, 계산결과에 의하면 총안정화에너지 값이 큰 중간체일수록 보다 쉽게 생성된다고 할 수 있다. 결과적으로 총안정화에너지의 상대적인 값은 가장 낮은 에너지의 d-d전이에 해당하는 파장의 빛을 쪼여줄 때 $trans-Cr^{Ⅲ}N_4XY$착물에서 어느 리간드가 우선적으로 불안정하게 되는가를 결정하는데 이용될 수 있으며, $trans-Cr^{Ⅲ}N_4XY$착물의 광수화반응에 있어서 떨어지는 리간드에 대한 이러한 예측은 실험상의 결과와 일치하고 있다. It is shown that the substitutive ligand on the photochemical substitution reactions of $trans-Cr^{Ⅲ}N_4XY$ complexes is predicted by considering the total stabilization energy of the hypothetical primary intermediates resulting from the loss of one ligand. The total stabilization energy and one electron energy level of d-orbital are calculated within the framework of angular overlap model. According to the calculated results, the intermediates with larger total stabilization energy are, as expected, more easily produced. Consequently, the relative values of the total stabilization energy are used to decide which of the ligands in $trans-Cr^{Ⅲ}N_4XY$ complexes is preferentially labilized on the lowest energy d-d irradiation. The prediction for the leaving ligand on the photoaquation of $trans-Cr^{Ⅲ}N_4XY$ complexes is consistent.

수용액에서 $[Co(en)_3]Cl_3$ 및 $[Co(NH_3)_6]Cl_3$착물의 이온 해리에 미치는 압력의 영향

정종재,노병길,Jong Jae Chung,Rho Byung Gill 대한화학회 1986 대한화학회지 Vol.30 No.4

$25{\circ}$에서 $[Co(en)]_3Cl_3,\;[Co(NH_3)_6Cl_3$수용액의 열역학적 해리상수를 1~2000bar의 압력범위에서 전도도법으로 측정하였다. 착물이 해리할 때 하전을 띤 이온이 생성하여 부피가 감소하므로 압력이 증가함에 따라 해리상수($K^T$)는 커졌다. 즉 $[Co(en)]_3Cl_3$에 대한 $pK^T$값은 1bar에서 2.16, 500bar에서 2.08, 1000bar에서 2.08, 1500bar에서 2.05, 2000bar에서 2.03이었고, $[Co(NH_3)_6Cl_3$의 $P^K^T$는 1bar에서 2.02, 500bar에서 1.96, 1000bar에서 1.90, 1500bar에서 1.88, 2000bar에서는 1.87이었다. 각 압력에서 Stokes반경과 해리상수($K^T$)값을 비교 분석하여 착물의 이온쌍 형성에는 정전기적 인력 이외에 Internal Conjugate Base(ICB)효과도 영향을 미쳤으며 이효과는 압력이 증가할 수록 커졌다. The thermodynamic dissociation constants of $[Co(en)]_3Cl_3\;and\;[Co(NH_3)_6Cl_3$ in aqueous solutions at $25{\circ}$ and at the pressure from 1 bar to 2000 bars were measured by conductometric method. The dissociation constants were increased with pressure elevation because of volume decreasing by the formation of charged ions during dissociation reaction. That is, the $pK^T$ values of $[Co(en)]_3Cl_3$ were 2.16 for I bar, 2.08 for 500 bars, 2,08 for 1000 bars, 2.05 for 1500 bars and 2.03 for 2000 bars, respectively and those of $[Co(NH_3)_6Cl_3$ were 2.02 for 1 bar 1.96 for 500 bars, 1.90 for 1000 bars, 1. 88 for 1500 bars and 1. 87 for 2000 bars, respectively. Comparing and analyzing the values of Stokes' radii and $K^T$, the formation of ion pair compound was affected by not only the electrostatic interaction, but also the Interal Conjugate Base(ICB), which was increased by the elevation of the pressure.

기-액 계면에서 Palmitic Acid 단분자막에 대한 pH, 알칼리토금속 이온의 영향 및 Hexadecanol 분자와의 섞임성

정종재,서병일,이해원,주민영,Jong-Jae Chung,Byung-Il Seo,Hai-Won Lee,Min-Young Ju 대한화학회 1993 대한화학회지 Vol.37 No.3

기-액 계면에서 Palmitic acid(PA) 단분자막의 ${\pi}$-A(surface pressure-area) 등온선 변화는 pH가 높을수록 가용화로 인하여 단위분자면적(${\AA}^2$/molecule)이 낮은 쪽으로 이동되었다. 바탕용액속에 Mg$^{2+}$, Ca$^{2+}$ 및 Ba$^{2+}$ 이온들을 각각 첨가했을 때 PA 분자는 압축되는 현상을 보였으며 이 효과는 이온의 농도 증가와 더불어 증가하였다. Langmuir-blodgett(LB) 다층막으로 IR 분광분석을 한 결과, PA는 이들이온과 각각 Mg, Ca, Ba-Palmitate 착물을 형성한다는 것을 알 수 있었다. 알칼리토금속 이온들에 의한 PA의 압축효과는 pH 8에서 Ca$^{2+}$ > Ba$^{2+}$ > Mg$^{2+}$ 순으로 나타났으며 Mg$^{2+}$ 을 제외하고는 원자번호 증가에 따라 감소되었다. 반면, 중성인 초순수 물에서는 Ba$^{2+}$ > Ca$^{2+}$ > Mg$^{2+}$ 순으로 나타났으며 이 현상은 원자번호가 낮아짐에 따라 감소하였다. 단분자막 상에서 PA와 HD(hexadecanol), 2성분계의 섞임성은 초순수 물인 계인 경우는 섞임성이 좋았으며 pH 8인 계의 경우는 섞임성이 나쁨을 알 수 있었다. ${\pi}$-A isotherms of the Palmitic acid(PA) with increasing pH shifted to the low area/molecule due to the dissociation of PA at the air-water interface. More condensation of PA monolayers occurred by the addition of Mg$^{2+}$, Ca$^{2+}$ and Ba$^{2+}$ ion in subphase. This condensing effect was increased with increasing the concentration of these ions. Due to the interaction with each ion, PA were formed Mg, Ca, Ba-Palmitate complex. The binding structure between alkaline earth ion and carboxylate ligand in PA has been identified by IR spectrometry. The order of condensing effect of alkaline earth ions at pH 8 was Ca$^{2+}$ > Ba$^{2+}$+ > Mg$^{2+}$. The condensing effect except for Mg$^{2+}$ decreased with increasing atomic number. Whereas, the condensing effect in pure water system decreased with decreasing atomic number in the sequence: Ba$^{2+}$ > Ca$^{2+}$ > Mg$^{2+}$. The miscibility of binary system of PA and hexadecanol in monolayer showed that the miscibility was good for the pure water system. But, in the buffered pH 8 system, bad miscibility was found.

요소 수용액에서 계면 활성제의 미셀화에 미치는 입력효과

鄭倧在,李相旭 慶北大學校 1986 論文集 Vol.41 No.-

The critical micelle concentrations (CMC) of dodecylpyridinium bromide (DoPB) in aqueous urea solutions have been determined over a range of pressures up to 2000 bars at 25° and 35℃. The partial molal volumes of DoPB in micellar (V￣_m) and singly dispersed states(V￣_s) have also been determined in aqueous urea solutions at 25℃. V￣_s increases with the addition of urea, while V￣_m remains approximately constant. The partial molal entropy change of micellization (ΔS￣_m in water increases with an increase in the pressure up to about 1000 bars, while ΔS￣_m in 2.94M urea solution remains virtually unaltered in the low-pressure region. The results suggest that the "iceberg" structure of water around the hydrocarbon chain of the monomeric surfactant is effectively broken down by urea.