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박윤규,송봉환 최신의학사 1975 最新醫學 Vol.18 No.3
The authors' report a case of spinal intradural arteriovenous malformation: involving the cervicothoracic spinal cord. Chief complains of the patient who was 27 year-old office man were quadriparesis and girdle pain in both upper extremities. The malformation was diagnosed by pantopaque myelography and clipped under the operatiig microscope.
구대서,김은가,박윤규 韓國非破壞檢査學會 1996 한국비파괴검사학회지 Vol.16 No.1
핵연료봉의 결함 탐상을 위하여 차동환상형 와전류시험 탐촉자를 설계 및 제작하여, 핵연료봉 시험을 위한 최적 시험 조건을 구하였다. 관통결함, 내부결함, 외부결함을 낸 표준시편에 대하여 와전류시험을 수행함으로써 시험 주파수와 출력 신호의 위상 및 크기에 대한 상관 관계를 구하였다. 이를 토대로 하여 고리원자력 1호기에서 연소한 핵연봉 G33-N2에 대하여 와전류시험을 수행하여 관통결함 신호를 얻었다. 와전류시험에서 관통결함으로 예측된 위치에서 금속조직시험을 수행하여 얻은 결과는 와전류시험결과와 잘 일치하였다. 따라서 와전류시험법은 조사핵연료봉의 피복관에 대한 건전성을 평가하는 도구로써 그 신뢰성이 양호함을 실증하였다. The eddy current test(ECT) probe of differential encircling coil type was designed and fabricated, and the optimum condition of ECT was derived for the examination of the irradiated fuel rod.. The correlation between ECT test frequency and phase & amplitude was derived by performing the test of the standard rig that includes inner notches, outer notches and through-holes. The defect of through-hole was predicted by ECT at the G33-N2 fuel rod irradiated in the Kori-1 nuclear power reactor. The metallographic examination on the G33-N2 fuel rod was performed at the defect location predicted by ECT. The result of metallographic examination for the G33-N2 fuel rod was in good agreement with that of ECT. This proves that the evaluation for integrity of irradiated fuel rod by ECT is reliable.
γ-Glutamyltranspeptidase가 肝細胞增殖에 미치는 影響
朴鈗圭,柳總根 고려대학교 의과대학 1992 고려대 의대 잡지 Vol.29 No.1
This study was intended to examine the role of γ-Glutamyltranspeptidase (γ-GT) in controlling hepatocyte proliferation and the mechanism of the enzyme action by which the enzyme manifests such effect. Adult rat hepatocytes were isolated and cultured to observe normal growth pattern. and the effect of inhibitor (serine-borate complex) of γ-GT upon hepatocyte proliferation, and to decide the concentration of enzyme inhibitor at which hepatocyte proliferation is inhibited. In addition. Changes of γ-GT activity and DNA synthesis were studied in the absence or presence of enzyme inhibitor employing primary culture of hepatocytes. The following results were obtained 1. Low initial cell density (5-6×10^(5)' cells/3S mm dish) and addition of insulin and EGF prompted hepatocyte proliferation. Whereby, Cell number increased up to 1.5 fold after 32 hours in comparison with initial cell number. 2. The concentration range of enzyme inhibitor in which hepatocyte proliferation was inhibited was more than 1 mM 3. During primary culture of hepatocytes, γ-GT activity showed rapid increase in lag phase on the basis of "zero" time and maximal increase in exponential growing phase. The increasing rate of γ-GT was weakened in stationary phase. 4. During primary culture of hepatocytes. The extent of DNA synthesis showed rapid increase in lag phase on the basis of ''zero" time and gradual increase in exponential growing phase and stationary phase. But. Such increase of DNA synthesis was lost by administration of enzyme inhibitor. The above results suggest that action and increased activity of γ-GT is necessary for increase of DNA synthesis in hepatocyte proliferation.