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Production and characterization of monoclonal antibodies against an avian influenza virus (H9N2)
Lim, Yong Hwan,Phan, Le Van,Mo, In-Pil,Koo, Bon-Sang,Choi, Young-Ki,Lee, Seung-Chul,Kang, Shien-Young The Korean Society of Veterinary Service 2017 韓國家畜衛生學會誌 Vol.40 No.3
In this report, fifteen monoclonal antibodies (MAbs) against an avian influenza virus (H9N2 subtype) were newly produced and characterized. These MAbs proved to react to the epitopes of nucleocapsid protein (NP), hemagglutinin (HA), neuraminidase (NA) and non-structural protein 1 (NS1) of Korean H9N2 strain, respectively. Two HA-specific MAbs showed the ability to inhibit the hemagglutination activity of H9N2 subtype avian influenza virus when tested by hemagglutination inhibition (HI) assay. All MAbs did not cross-react with other avian-origin viruses (Newcastle disease virus, infectious bursal disease virus, infectious bronchitis virus and avian rotavirus) by immunofluorescence test or enzyme-linked immunosorbent assay. The MAbs produced in this study could be useful as the materials for diagnostics and therapeutics against Korean-lineage H9N2 virus infections.
Improvement of Recovery Characteristics of a Flux-Lock Type SFCL Using a Superconductor's Trigger
Sung-Hun Lim,Jae-Chul Kim,Bang-Wook Lee IEEE 2010 IEEE transactions on applied superconductivity Vol.20 No.3
<P>To achieve the effective performance of the flux-lock type superconducting fault current limiter (SFCL), the countermeasures to improve the recovery characteristics of the flux-lock type SFCL are required. In this paper, as one of the solutions, the method using a superconductor's trigger when the quench in the high-TC superconducting (HTSC) element occurred was suggested. To verify the suggested method in case of the fault occurrence, the control circuit to detect the quench of HTSC element and the current limiting resistor (CLR) to limit the fault current were designed and fabricated. With the fabricated control circuit and the CLR, the fault current limiting and recovery characteristics of the flux-lock type SFCL using the suggested method were tested. Through the analysis for the experimental results, the recovery characteristics of the flux-lock type SFCL could be confirmed to be improved than the SFCL not using the superconductor's trigger.</P>
( Sang Gyun Kim ),( Seon Mi Ji ),( Na Rae Lee ),( Seung-Hee Park ),( Ji Hye You ),( Il Ju Choi ),( Wan Sik Lee ),( Seun Ja Park ),( Jun Haeng Lee ),( Sang-Yong Seol ),( Ji Hyun Kim ),( Chul-Hyun Lim ) 대한소화기학회 2017 Gut and Liver Vol.11 No.1
Background/Aims: Endoscopic submucosal dissection (ESD) has been an established treatment for indicated early gastric cancer (EGC) without deterioration of quality of life (QOL) compared with surgical resection. The aim of this study was to evaluate long-term QOL in patients undergoing ESD for EGC. Methods: Patients scheduled to undergo curative ESD for EGC were prospectively enrolled from 12 institutions between May 2010 and December 2011. Assessments of QOL with Korean versions of the European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaire- core (QLQ-C30) and a gastric cancer-specific questionnaire (STO22) were performed at baseline and at 7 days, 3 months, and 6 months after ESD. Results: A total of 666 subjects were assessed for QLQ-C30 and QLQ-STO22. The mean QLQ-C30 score was 69.5 at baseline, 68.8 at 7 days, 73.1 at 3 months, and 73.2 at 6 months. The global health status on the EORTC QLQ-C30 was significantly improved after 3 and 6 months (p=0.0003 and p<0.0001, respectively). The QLQ-C30 and STO22 scores were not significantly different, or they only slightly deteriorated between before and immediately after ESD, but they were significantly improved after 3 and 6 months (p<0.05). Conclusions: QOL did not deteriorate immediately after ESD, and it improved more significantly at up to 6 months in patients who underwent curative ESD for EGC without significant complications. (Gut Liver 2017;11:87-92)
( Sang Gyun Kim ),( Chan Mi Park ),( Na Rae Lee ),( Jiyoung Kim ),( Da Hyun Lyu ),( Seung-Hee Park ),( Il Ju Choi ),( Wan Sik Lee ),( Seun Ja Park ),( Jae Jun Kim ),( Ji Hyun Kim ),( Chul-Hyun Lim ),( 대한소화기학회 2018 Gut and Liver Vol.12 No.4
Background/Aims: Endoscopic submucosal dissection (ESD) has been regarded as a curative treatment for early gastric cancer (EGC) in indicated cases. The aim of this study was to evaluate the nationwide long-term clinical outcomes of ESD for EGC in Korea. Methods: A prospective multicenter cohort study was performed to evaluate the long-term efficacy of ESD for EGC within pre-defined indications at 12 institutes in Korea. The cases that met the expanded criteria upon pathological review after ESD were followed for 5 years. The primary outcome was 5-year disease specific free survival. Results: Six hundred ninety-seven patients with 722 EGCs treated with ESD were prospectively enrolled and followed for 5 years. Complete resection was achieved in 81.3% of the cases, and curative resection was achieved in 86.1%. During the 5-year follow-up, the overall survival rate was 96.6%, and the disease specific free survival rate was 90.6%. Local recurrence developed in 0.9%, and metachronous tumor development occurred in 7.8%; both conditions were treated by endoscopic or surgical treatment. Distant metastasis developed in 0.5% during follow-up. Conclusions: ESD showed excellent long-term clinical outcomes and can be accepted as a curative treatment for patients with EGC who meet the expanded criteria in final pathology studies. (Gut Liver 2018;12:402-410)
Lim, Soo,Kang, Seon Mee,Kim, Kyoung Min,Moon, Jae Hoon,Choi, Sung Hee,Hwang, Hee,Jung, Hye Seung,Park, Kyong Soo,Ryu, Jun Oh,Jang, Hak Chul Springer International 2016 Acta diabetologica Vol.53 No.2
<P>In 2011, we demonstrated that an individualized health management system employing advanced medical information technology, designated ubiquitous (u)-healthcare, was helpful in achieving glycemic control without hypoglycemia in patients with diabetes. Following this, we generated a new multidisciplinary u-healthcare system by upgrading our clinical decision support system (CDSS) rule engine and integrating a physical activity-monitoring device and dietary feedback into a comprehensive package. In a randomized, controlled clinical trial, patients with type 2 diabetes aged over 60 years were assigned randomly to a self-monitored blood glucose (SMBG) group (N = 50) or u-healthcare group (N = 50) for 6 months. The primary endpoint was the proportion of patients achieving glycated hemoglobin (HbA(1c)) < 7 % without hypoglycemia. Changes in body composition and lipid profiles were also investigated. The u-healthcare group was educated to use a specially designed glucometer and an activity monitor that automatically transferred test results to a hospital-based server. An automated CDSS rule engine generated and sent patient-specific messages about glucose, diet, and physical activity to their mobile phones and a Web site. After 6 months of follow-up, the HbA(1c) level was significantly decreased in the u-healthcare group [8.0 +/- A 0.7 % (64.2 +/- A 8.8 mmol/mol) to 7.3 +/- A 0.9 % (56.7 +/- A 9.9 mmol/mol)] compared with the SMBG group [8.1 +/- A 0.8 % (64.9 +/- A 9.1 mmol/mol) to 7.9 +/- A 1.2 % (63.2 +/- A 12.3 mmol/mol)] (P < 0.01). The proportion of patients with HbA(1c) < 7 % without hypoglycemia was greater in the u-healthcare group (26 %) than in the SMBG group (12 %; P < 0.05). Body fat mass decreased and lipid profiles improved in the u-healthcare group but not in the SMBG group. This u-healthcare service provided effective management for older patients with type 2 diabetes (ClinicalTrial.Gov: NCT01137058).</P>
Lim, Sang-Gu,Baeck, Jae Min,Kim, Chul Won,Kim, Young Soo The Korean Society of Developmental Biology 2014 발생과 생식 Vol.18 No.3
Rearing experiments were conducted using several regimes combined with different photoperiods and water temperatures to investigate the role of temperature and photoperiod as environmental cues regulating reproduction in red marbled rockfish, Sebastiscus tertius. The initial gonadosomatic index (GSI) was $1.62{\pm}0.32%$ and that in the $15^{\circ}C$ control was $7.01{\pm}0.46%$ at the end of the experiment. The highest GSI was $9.10{\pm}0.35%$ in the 12L:12D photoperiod-treated fish. The highest GSI at $19^{\circ}C$ was $15.03{\pm}0.86%$ in the 12L:12D photoperiod treatment. The initial hepatosomatic index (HSI) was $3.09{\pm}0.72%$ and that in the $15^{\circ}C$ control was $3.88{\pm}0.45%$. The highest HSI was $4.00{\pm}0.56%$ in the 15L:9D treated fish. The highest HSI at $19^{\circ}C$ was $4.05{\pm}0.63%$ in the 12L:12D treated fish.