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RISS 인기검색어
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- 저자 : ( Soo Yong Chough ) (검색결과 28 건)
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Flow Cytometric DNA Content Study on Uterine Leiomyomatous Tumors
Chough, Soo Yong,Lee, Kap N. 中央醫學社 1993 中央醫學 Vol.58 No.2
Flow cytometric DNA content analysis of 21 cases of benign leiomyomas, 2 cases of symplastic leiomyomas, 1 case of atypical leiomyoma, 1 case of borderline malignancy of leiomyoma and 3 cases of leiomyosarcomas with paraffin blocks from uterine hysterectomy specimen were performed. Only two cases out of 21 cases of benign leiomyomas (9 %) showed aneuploid patterns, one out of three leiomyosarcomas was aneuploidy and all others were diploidy. In histograms, the only G2 + M/G1 ratio fraction showed significant differences between benign leiomyomas and other symplastic, atypical leiomyomas, borderline malignancy of leiomyoma and leiomyosarcomas (P < 0.05). In histogramic fractions between benign and non-benign tumors, there were very significant differences in Go + M/Gi ratio (P < 0.001). There were no differences in ploidy pattern, Go/G1 fraction; S phase fraction, G2 + M fraction, prolifereation index and DNA index. Between benign leiomyomas and leiomyosarcomas, in cases of diploid tumors, only G2 + M/G1 ratio showed significant difference (P < 0.05) and in cases of aneuploid tumors, there was only suggestion of difference in only Go/G1 fraction.
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Flow cytometric DNA content study on Uterine Leiomyomatous tumors
Chough, Soo Yong,Lee, Kap N. 고려대학교 의과대학 1993 고려대 의대 잡지 Vol.30 No.2
종양에서 세포의 비정상적인 분열산은 종양의 한 특징으로 생각되어 왔다. 이러한 종양의 한 특징인 세포의 분열상을 연구하는 여러 방법중 최근에 소개된 유세포측정법을 이용한 세포의 분열상에 대한 연구가 활발하다. 그러나 대부분 epithelial세포에 관한 연구 논문들이고 sarcomatoid세포에 관한 연구는 드물다. 이에 본 연구자들은 고려대학교 부속병원들에서 자궁 절제술로 제거된 평활근 종양 중 양성 자궁 평활근종 21예, 심프라스틱(symplastic) 자궁 평활근종 2예, 이형성(atypical) 자궁평활근종 1예, 경계형(borderline) 자궁 평활근종 1예와 악성 평활근종 3예를 대상으로 이들의 파라핀 포매된 조직중 대표적인 것을 선정하여 유세포 측정을 시행하고 그 분열상에 있어서 어떠한 특징이 있는지 비교 검토한 결과, 21예의 양성 자궁 평활근종중 단지 2예와 3예의 악성 자궁 평활근종중 1예에서만 이수배수체(aneuploidy) 양상을 보였고, 다른 모든 예에서는 이배체(diploidy)를 보였다. 히스토그램 분석상, 양성 자궁 평활근종과 심프라스틱, 이형성, 경계형 자궁 평활근종과 악성 평활근종의 G_(2)+M/G_(1)비에서 유의한 차이를 보여 주었으며(P<0.05), G_(2)+M/G_(1)비에서는 양성과 양성이 아닌 군사이에서 아주 유의한 차이를 보여 주었다(P<0.001). 그러나 배수성 양상, G_(0)/G_(1), S, G_(2)/M, 증식지수(proliferation index)와 DNA지수는 어느 군사이에서도 차이를 보여주지 않았다. 양성종양(leiomyoma) 및 악성종양(leiomyosarcoma)의 이배체군과 이수배수체군들 사이의 각각의 비교에서 이배체군의 G_(2)+M/G_(1)비에서 유의한 차이를 보여주었고, 이수배수체군에서 G_(0)/G_(1)비에서 다소의 차이를 보여 주었으나 통계학적으로 유의하지는 않았다. Flow cytometric DNA content analysis of 21 cases of benign leiomyomas, 2 cases of symplastic leiomyomas, 1 case of atypical leiomyoma, 1 case of borderline malignancy of leiomyoma and 3 cases of leiomyosarcomas with paraffin blocks from uterine hysterectomy specimen were performed. Only two cases out of 21 cases of benign leiomyomas (9%) showed aneuploid patterns, one out of three leiomyosarcomas was aneuploidy and all others were diploidy. In histograms, the only G_(2)+M/G_(1) ratio fraction showed significant differences between benign leiomyomas and other symplastic, atypical leiomyomas, borderline malignancy of leiomyoma and leiomyosarcomas(P<0.05). In histogramic fractions between benign and non-benign tumors, there were very significants differences in G_(0)+M/G_(1) ratio(P<0.001). There were no differences in ploidy pattern, G_(0)/G_(1) fraction, S phase fraction, G_(2)+M fraction, proliferation index and DNA index. Between benign leiomyomas and leiomyosarcomas, in cases of diploid tumors, only G_(2)+M/G_(1) ratio showed significant difference (P<0.05) and in cases of aneuploid tumors, there was only suggestion of difference in only G_(0)/G_(1) fraction.
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수술 후 폐경 여성과 자연폐경 여성에서 인슐린양 성장인자 및 생화학적 지표의 비교
조수용(Soo Yong Chough),김세규(Se Kyu Kim),이재관(Jae Kwan Lee) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2
N/A Objective: The purpose of this study was to investigate possible menopause related changes in circulating insulin-like growth factor binding protein 3 (IGFBP-3) levels and their relationship with insulin-like growth factor 1 (IGF-1) plasma levels, osteocalcin(Ost) and urinary deoxypyridinoline(Dpd) in either surgical menopause or natural menopause, Method: Seventy-two postmenopausal women (surgical menopause 48, natural menopause 24) were invited to participate in this study. In all subjects plasma IGF-1 and IGFBP-3 levels were measSURED by radioimmunoassay and Ost and Dpd were measured by enzyme linked immunosorbent assay(ELISA). Results: No difference was found between mean IGFBP-3 plasma levels in the two groups studied(3,522 +- 926 vs 3,854 +- 569 ng/ml), while mean IGF-1 levels were significantly lower in natural menopause as compared with surgical menopause (natural 126 +- 44 vs surgical 163 +- 66 ng/ml, p 0.007). No difference was found between mean Ost levels in the two groups studied (natural menopause 8.0 +- 2.9 vs surgical menopause 8,9 +- 2.1 ng/ml, p 0.113) and mean Dpd levels in the two studied (natural menopause 6.8 +- 2.3 vs surgical menopause 7.8 +- 3.4 mM, p 0.213). Conclusion: IGF-1 was significantly lower in natural menopause as compared with surgical menopause, but no significant difference was found in IGFBP-3, Ost, and Dpd levels
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