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( Rajendra Kc ),( Madhab Lamsal ),( Prahlad Karki ),( Shankar Majhi ),( Nirmal Baral ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Several potential cardiovascular risk factors were reported in patients with subclinical hypothyroidism (SCH) but the association still remains controversial therefore, we aimed to evaluate cardiovascular risk factors in subjects with subclinical hypothyroidism. Methods: A total of 100 subjects with subclinical hypothyroidism and 100 age and gender matched euthyroid controls, were included in the study. Serum free T3, free T4 and TSH were estimated by fl uorescent immunoassay. Total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were assayed by enzymatic colorimetric method, and high sensitivity C-reactive protein (hs-CRP) by enzyme immunoassay. Data were analyzed by SPSS version 20. Results: Mean levels of diastolic blood pressure (82.1±6.0 vs 79.1±6.1 mmHg, p=0.001), total cholesterol (199.6±31.6 vs 184.3±30.8 mg/dl, p=0.001) and LDL-C (104.0±27.5 vs 94.6±25.4, p=0.012), and median hs-CRP (0.92 (0.30-2.17) vs 0.56 (0.33-1.35), p=0.03) were significantly higher in SCH than the euthyroids. Within the SCH group, mean diastolic blood pressure, TC, LDL-C, and median hs-CRP levels were signifi cantly higher in subjects with TSH=10 mU/L than those with TSH<10 mU/ L. Individual analysis revealed that the prevalence of borderline elevated total cholesterol (=200mg/dL), elevated LDL-C (=100mg/dL) and raised hs-CRP (=3mg/L) were signifi cantly higher in SCH than ineuthyroid group. TSH levels in SCH was positively correlated with diastolic blood pressure (r=0.33, p=0.001), total cholesterol (r=0.39, p<0.001), LDL-C (r=0.42, p<0.001) and hs-CRP (r=0.51, p<0.001). Conclusions: Subclinical hypothyroidism was associated with higher diastolic blood pressure, higher total cholesterol, LDL-C and higher hs-CRP levels, this might increase the risk of accelerated arteriosclerosis.