The Effect of Liquid Crystalline Phase Formation on Preservation

( Seung-gak Yang ),( Won-jae Park ),( Ok-sub Lee ),( Hyuck-chel Kwon ) 대한화장품학회 1986 대한화장품학회지 Vol.12 No.1

The effect of liquid crystalline phase formation on preservation in ternary and O/W emulsion systems was investigated. Antimicrobial activity of methyl paraben in tested systems was more enhanced with the increasing concentration of fatty alcohols such as myristyl, cetyl, stearyl and cetostearyl alcohol except lauryl alcohol. With the increasing addition of such fatty alcohols, the increasing quantity of free methyl paraben in tested systems was determined by equilibrium dialysis method. The liquid crystal formed in presence of fatty alcohols was observed by a microscope under polarized light. However, liquid crystal could not be observed only in lauryl alcohol. From these results, we could conclude that the formation of liquid crystalline phase affects decrease of the micelle quantity and suppresses inactivation of methyl paraben.

Long-term outcome of isolated thrombocytopenia accompanied by hypocellular marrow

Gak-Won Yun,Young-Jun Yang,송익찬,Seung-Woo Baek,Kyu-Seop Lee,이효진,Hwan-Jung Yun,Kye-Chul Kwon,Samyong Kim,조덕연 대한혈액학회 2011 Blood Research Vol.46 No.2

Background :Hypocellularity of bone marrow (BM), not associated with significant dyshematopoiesis, is often found in patients with isolated thrombocytopenia, but its clinical implications have not been studied. We prospectively studied the clinical features and natural history of these patients. Methods :Adults with isolated thrombocytopenia (platelet counts <100×109/L) in the absence of dyshematopoiesis, cytogenetic abnormalities, or megakaryocytic hyperplasia and who had BM hypocellularity (below 30% in patients aged less than 60 years; below 20% in patients aged 60 years or more) were enrolled at Chungnam National University Hospital between January 2002 and December 2006. They were monitored regularly for changes in platelet counts or development of additional cytopenia. Results :Twenty patients (17 men and 3 women) were enrolled in the study. The median age was 29 years (range, 18-70 years). At initial presentation, the platelet counts ranged from 12 ×109/L to 99×109/L (median, 63×109/L) and were >50×109/L in 16 patients (80%). BM cellularity ranged from 5% to 25% (median, 15%) and was ≤10% in 6 patients (30%). During the median 48-month follow-up (range, 12-90 months), platelet counts of 3 of the 20 patients recovered to normal levels (>150×109/L) after 12, 56 and 66 months. Three patients developed pancytopenia after 11, 70 and 90 months. Two patients were consistent with moderate aplastic anemia, and 1 was confirmed as having refractory cytopenia with multilineage dysplasia. In the remainder of the patients, platelet counts remained unchanged. Conclusion :Isolated thrombocytopenia accompanied by hypocellular marrow encompasses a group of heterogeneous conditions.

Clinical Implications of Elevated Antiphospholipid Antibodies in Adult Patients with Primary Immune Thrombocytopenia

( Young Joon Yang ),( Gak Won Yun ),( Ik Chan Song ),( Seung Woo Baek ),( Kyu Seop Lee ),( Hye Won Ryu ),( Myung Won Lee ),( Hyo Jin Lee ),( Hwan Jung Yun ),( Sam Yong Kim ),( Deog Yeon Jo ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.4

Background/Aims: Antiphospholipid antibodies (aPL) have been detected in various proportions of patients with primary immune thrombocytopenia (ITP), but the clinical significance of this is debatable. The present study aimed to determine the frequency and clinical implications of elevated aPL in adult patients with ITP. Methods: We prospectively studied newly diagnosed adult patients with ITP who were enrolled between January 2003 and December 2008 at Chungnam National University Hospital. They were evaluated for the presence of lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) at diagnosis and were followed for the development of thrombosis. Results: Seventy consecutive patients with ITP (median age, 48 years; range, 18 to 79) were enrolled. Twenty patients (28.5%) were positive for aPL at the time of diagnosis: aCL alone in 15 (75%), aCL and LA in two (10%), and LA alone in three (15%). Patients who had platelet counts < 50,000/μL were administered oral prednisolone with or without intravenous immune globulin. No difference was found between the aPL-positive and -negative groups regarding gender, initial platelet count, and response to the therapy. After a median follow-up of 20 months (range, 2 to 68), two of 20 patients who were aPL-positive (10%) developed thrombosis, whereas no thrombotic event was found among those who were aPL-negative. Conclusions: Our data suggest that aPL levels should be determined at the initial presentation of ITP and that patients found to be aPL-positive should receive closer follow-up for thrombotic events.

영성문화자원으로서 남양성모성지의 가치를 통한 지역관광활성화 연구

이상각(Lee, Sang-gak),양승탁(Yang, Seung-tak) 한국문화융합학회 2019 문화와 융합 Vol.41 No.3

This study has been done for the purpose of activating local tourism by utilizing resources that hold attraction as spirituality cultural resources. These include holy and religious sites as well as healing tourism. Furthermore, if religious facilities are included to develop various programs, these will be great resources for activating local tourism. Therefore, this research tries to suggest strategies for linking The Shrine of Our Lady of the Rosary of Namyang, located in Hwaseong, Gyeonggi do, with local tourism; this has been done by estimating its value as a religious facility and spirituality cultural resource, and considering its preservation value as a tourism resource. In the case of this area, a cathedral and peace cultural sharing center are being built by a global architec and these areas will be used not only as religious facilities but also as a concert hall, library, and exhibition hall. What is more, these will be social and cultural facilities for local residents. The value of this structure, The Shrine of Our Lady of the Rosary of Namyang, has been estimated through the Contingent Valuation Method (CVM). For this contingent valuation, a survey was conducted from January 15, 2018 to February 28, 2018. This survey identified locals here and visitors illingness to make a donation for establishing The Shrine of Our Lady of the Rosary of Namyang and analyzed the responses empirically. Based on the result from CVM, WTP truncated mean of the value of The Shrine of Our Lady of the Rosary of Namyang is approximately 329,273 Korean Won per house. The total preservation value is expected to be 102.5 billion Korean Won. Such a value may show major donation willingness from Catholics, as this is a religious facility. However, as a result of estimation based on a logit model, main variables affecting donation intention include suggested price, level of support for facility establishment, and local identity. This implies that enhanced local identity may influence payment value of local spirituality cultural resources; also, level of support for establishing a cathedral and peace cultural center affected its payment value as well. The value of The Shrine of Our Lady of the Rosary of Namyang as a spirituality cultural resource is confirmed through this research. If its image as a local tourism resource is promoted through development of various programs, it will lay a strong foundation for activating local tourism. 본 연구는 영성문화자원으로서 관광적 매력을 지닌 자원의 활용을 통해 지역관광의 활성화를 위한 관점에서 진행되었다. 영성문화자원은 성지관광, 종교관광, 치유관광의 개념을 포함한 보다 넓은 범위의 활동을 위한 자원이 될 수 있으며, 종교적 시설을 이용하여 다양한 프로그램을 활용한다면 지역관광 활성화에 기여할 수 있는 자원이 될 수 있다. 따라서 경기도 화성시에 위치한 남양성모성지를 대상으로 종교적 시설인 영성문화자원의 가치를 추정하여 단순한 시설적 가치 외에 관광자원으로서의 보존가치를 파악해 봄으로써 지역관광과 연계할 수 있는 전략을 제시하고자 하였다. 특히 남양성모성지의 경우 세계적인 건축가에 의해 대성당과 평화문화나눔센터가 건립중이며, 이러한 시설은 단순 종교시설이 아닌 콘서트홀, 도서관, 북카페, 상설 및 기획전시관 등으로 이용될 예정이며, 지역주민을 위한 사회 문화적 시설로 활용될 예정이다. 이에 가상가치추정법(CVM)을 통해 남양성모성지의 건축물 건립에 대한 가치를 추정하였다. 가치추정을 위해 2018년 1월 15일부터 2월 28일까지 설문조사를 실시하였으며, 총 374명의 의견을 토대로 남양성모성지의 건축물 건립에 대한 개발기부금의 명목으로 지불의사를 파악하여 실증분석에 활용하였다. CVM을 통해 추정된 남양성모성지의 가치는 절단된 평균값(WTP truncated mean)을 기준으로 할 경우 가구당 329,273원으로 추정되었으며, 총 보존가치는 약 1,025억 원으로 추정되었다. 이는 종교적 시설이라는 특성 상 천주교 신도 여부가 지불의사에 많이 반영되긴 하였으나, 로짓모델 추정 결과 지불의사에 영향을 미치는 주요 변수로 제시금액, 시설 건립에 대한 지지도, 지역의 정체성 등이 영향을 미치는 것으로 나타났다. 이는 결과적으로 지역에 대한 정체성의 향상이 지역 내 영성문화자원에 대한 지불가치에도 영향을 줄 수 있으며, 대성당과 평화문화나눔센터 등의 건립에 대한 지지도 역시 영성문화자원에 대한 지불가치에도 영향을 주는 것을 확인하였다. 본 연구를 통해 영성문화자원으로서 남양성모성지의 가치를 확인하였으므로, 향후 이러한 시설을 기반으로 다양한 프로그램의 개발을 통해 지역관광자원으로의 이미지를 부각시키고 발전시키면 지역관광 활성화를 위한 기초가 될 수 있을 것이다.

유산균의 활성산소 소거 및 면역증강효과

이호(Ho Lee),양승각(Seung Gak Yang),박수남(Soo Nam Park),전도용(Do Yong Jeon) 한국생물공학회 1992 KSBB Journal Vol.7 No.4

증례 : 혈액종양 ; 여러 내장에 재발한 다발고립형질세포종 1예

송익찬 ( Ik Chan Song ),백승우 ( Seung Woo Baek ),이규섭 ( Kyu Seop Lee ),윤각원 ( Gak Won Yun ),양영준 ( Young Jun Yang ),김진만 ( Jin Man Kim ),조덕연 ( Deog Yeon Jo ) 대한내과학회 2011 대한내과학회지 Vol.80 No.5

다발고립형질세포종은 고립형질세포종의 약 5%를 차지하는 매우 드문 질환이다. 저자들은 뼈의 다발고립형질세포 종으로 치료받은 후 완전반응 상태를 유지하던 중, 여러 내장기관에 골수외형질세포종의 형태로 재발한 매우 드문 경우의 다발고립형질세포종을 경험하였다. 뼈의 다발고립형질 세포종으로 치료받은 경력이 있는 68세 남자에서 배뇨곤란 및 변비가 발생하였다. 복부 및 골반의 전산화단층촬영에서 위, 췌장, 골반강 및 우측 둔부에 덩이가 발견되었으며, 위의 덩이에 대한 내시경 조직검사에서 형질세포종이 확인되었다. 이 환자는 내원 20개월 전, 우측 제 6 늑골 및 우측 장골의 다발고립형질세포종으로 방사선 치료를 받았고, 내원 14개월 전에는 좌측 제 5, 6, 7, 9 늑골에 재발하여 방사선 치료를 받았으며, 내원 12개월 전에는 제 5경추에 재발하여 방사선 치료 및 VAD 화학요법을 시행 받은 적이 있었다. 골반강의 덩이에 대한 방사선치료와 bortezomib+dexamethaone 화학요법으로 모든 덩이는 소실되었고, 8개월째 재발의 증거 없이 경과관찰 중이다. 향후 다발고립형질세포종의 임상 경과 및 치료와 예후인자에 관한 연구가 필요할 것으로 생각 된다. Multiple solitary plasmacytoma is a very rare disease entity, which occurs in up to 5% of patients with solitary plasmacytomas. We report an atypical case of multiple solitary plasmacytoma that recurred in multiple visceral organs without any evidence of bone marrow involvement. A 68-year-old male presented with voiding difficulty. Twenty months earlier, he had been placed on local radiotherapy for solitary plasmacytomas in the right 6th rib and right iliac bone. Recurrences were noted 14 and 12 months later in several ribs and the 5th cervical vertebra, respectively. These were well controlled with local radiotherapy and conventional systemic chemotherapy. He had multiple soft tissue masses in the stomach, pancreas, pelvic cavity, and right buttock. An endoscopic biopsy of the gastric mass confirmed the diagnosis of plasmacytoma. Local radiotherapy to the pelvic mass and systemic therapy consisting of bortezomib and dexamethasone were given, and he has been well for 8 months.

Ion Shower Doping Effect in Diamond - Like Carbon Films

Soo Chul Chun,Kyu Chang Park,Kyo Jun Song,Jae Gak Kim,Seung Min Lee,Min Park,Myung Hwan Oh,Seong Soo Choi,Jung Hae Park,In Sang Yang,Jin Jang 한국진공학회 1995 한국진공학회 학술발표회초록집 Vol.- No.-

상백피의 Sanggenon C에 의한 Streptococcus mutans의 생육 및 균부착 저해효과

박원재(Won Jae Park),이형재(Hyung Jae Lee),양승각(Seung Gak Yang) 대한약학회 1990 약학회지 Vol.34 No.6

The methanolic extract of the root-bark of Morus alba L.(Mulberry tree) has the potent antibacterial activity against Streptococcus mutans. Its active component was identified to be sanggenon C. The active had stronger anti-bacterial activity than berberine, having minimum inhibitory concentration(MIC) of 25mcg/ml. Moreover, the inhibitory effect of this component on the cellular adherence of streptococcus mutans to glass surfaces also was more remarkable than that of berberine in the presence of glucosyltransferase(GTase) and sucrose in vitro. These results indicated that sanggenon C may play an important role in inhibiting plaque formation and caries incidence.