http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Ravi Daswani ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Role of liver transplantation in severe alcoholic hepatitis
( Ravi Daswani ),( Ashish Kumar ),( Praveen Sharma ),( Vikas Singla ),( Naresh Bansal ),( Anil Arora ) 대한간학회 2018 Clinical and Molecular Hepatology(대한간학회지) Vol.24 No.1
Severe alcoholic hepatitis has very high short term mortality and corticosteroids have been the mainstay of treatment for decades. Patients with Lille score >0.45 are considered non-responders to steroids and have poor outcome. Recently Orthotopic Liver Transplantation (OLT) is being increasingly used as rescue treatment for these patients, without waiting for 6 months of abstinence. Liver transplant is the only rescue treatment which can potentially provide long term benefit for patients who are steroid non-responders. However, with scarcity of organs being a concern, all patients of severe alcoholic hepatitis cannot be chosen for transplantation in an arbitrary way. There is a need for development of predictive tools and objective protocols to select patients who can justify the use of precious liver grafts. With a stringent criteria for selection of patients receiving the graft, liver transplantation in severe alcoholic hepatitis can become a viable rescue therapeutic option conferring significant survival advantage of both short- and long-term basis. The optimal criteria for selection will also prevent misuse of the liver donor pool as well as to prevent mortality in salvageable patients. Further research needs to be done to identify subset of patients which are at low risk of recidivism and also cannot be managed with pharmacotherapy alone. We reviewed the current knowledge on role of OLT in patient with acute severe alcoholic hepatitis in the present review. (Clin Mol Hepatol 2018;24:43-50)
-
( Ravi Daswani ),( Anil Arora ),( Ashish Kumar ),( Praveen Sharma ),( Shrihari A ),( Pankaj Puri ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Hepatitis B, hepatitis C, alcohol, and non-alcoholic ste atohepatitis are important etiological factors for hepatocellular carcinoma (HCC). Role of diabetes mellitus (DM) as a contributory factor for HCC in patients with viral etiology has been adequately demonstrated, however its role in HCC due to alcohol and NASH remains controversial. This case-control study aimed to investigate the association of DM with HCC in patients with alcoholic liver disease and cryptogenic (including NASH-related) liver disease. Methods: We conducted this case-control study at Sir Ganga Ram Hospital, Delhi, India. Consecutive patients of HCC due to alcohol or cryptogenic etiologies presenting between 2011 and 2017 were included in the study as cases. Age and sex matched patients of chronic liver disease of same etiologies, presenting during the same period, were chosen as controls. Cases and controls were in the ratio of 1:2. Patients of any other etiologies were excluded. Prevalence of DM among cases and controls were compared. Results: A total of 138 patients of HCC (mean age 61±9 years, 95% males) were included in the study. The etiologies of HCC were cryptogenic (including NASH) 54%, and alcohol 46%. DM was present in 48% of patients. A total of 276 controls (mean age 61±7 years, 92% males; P=NS compared to cases) were in cluded in the study. Among patients of HCC due to cryptogenic / NASH etiology, the prevalence of DM was significantly higher than in controls (P=0.012; OR 2.3, 95% CI 1.2, 4.3). Among patients of HCC due to alcohol etiology the prevalence of DM was similar to that of controls (P=NS). Conclusions: DM is strongly associated with the increased risk of HCC in patients of cryptogenic / NASH etiology. Therefore, these patients represent a high HCC risk population and should be considered for closer HCC surveillance program. DM does not seem to increase the risk of HCC in patients of chronic liver disease due to alcohol etiology.
KCI
KISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
