http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Long non-coding RNA: its evolutionary relics and biological implications in mammals: a review
( Jasdeep Kaur Dhanoa ),( Ram Saran Sethi ),( Ramneek Verma ),( Jaspreet Singh Arora ),( Chandra Sekhar Mukhopadhyay ) 한국축산학회(구 한국동물자원과학회) 2018 한국축산학회지 Vol.60 No.10
The central dogma of gene expression propounds that DNA is transcribed to mRNA and finally gets translated into protein. Only 2-3% of the genomic DNA is transcribed to protein-coding mRNA. Interestingly, only a further minuscule part of genomic DNA encodes for long non-coding RNAs (lncRNAs) which are characteristically more than 200 nucleotides long and can be transcribed from both protein-coding (e.g. H19 and TUG1) as well as noncoding DNA by RNA polymerase II. The lncRNAs do not have open reading frames (with some exceptions), 3`- untranslated regions (3’-UTRs) and necessarily these RNAs lack any translation-termination regions, however, these can be spliced, capped and polyadenylated as mRNA molecules. The flexibility of lncRNAs confers them specific 3Dconformations that eventually enable the lncRNAs to interact with proteins, DNA or other RNA molecules via base pairing or by forming networks. The lncRNAs play a major role in gene regulation, cell differentiation, cancer cell invasion and metastasis and chromatin remodeling. Deregulation of lncRNA is also responsible for numerous diseases in mammals. Various studies have revealed their significance as biomarkers for prognosis and diagnosis of cancer. The aim of this review is to overview the salient features, evolution, biogenesis and biological importance of these molecules in the mammalian system.
Pulmonary Artery Stenosis due to Lung Carcinoma: A Rare Cause of Dyspnea
Rajiv Bharat Kharwar,Akhil Sharma,Rishi Sethi,Varun Shankar Narain,Ram Kirti Saran 한국심초음파학회 2014 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.22 No.4
Acquired bilateral pulmonary artery stenosis in adults due to lung malignancy is infrequently reported. We describe an adultmale who presented to us with chief complaints of dyspnea on exertion and one episode of hemoptysis. Two dimensionaltransthoracic echocardiography with color Doppler showed presence of an extra cardiac mass causing severe extrinsic compressionof both the right and left pulmonary artery leading to high pressure severe tricuspid regurgitation and extension of the mass intothe left atrium. Three dimensional transthoracic echocardiography clearly delineated the anatomy of the left atrial mass and itssurrounding anatomical relationship. The diagnosis of non small cell lung carcinoma was confirmed by multidetector computedtomography (MDCT) and with MDCT guided biopsy with histopathology. Patient succumbed one month later due to anepisode of massive hemoptysis.