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- 저자 : ( Peter Lakatos ) (검색결과 2 건)
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Serum Anti-Saccharomyces Cerevisiae Antibodies in Greek Patients with Behcet’s Disease
George Vaiopoulos,Kostas Konstantopoulos,Peter Laszlo Lakatos,Maria Papp,Faedon Kaklamanis,Efrosyni Economou,Vassilis Zevgolis,John Sourdis 연세대학교의과대학 2011 Yonsei medical journal Vol.52 No.2
We tested 59 Greek patients with Behcet’s Disease (BD) for serum anti-Saccharomyces cerevisiae antibodies. No increase of these antibodies was detected in the cases compared to 55 healthy unrelated blood donors from the same population. This finding is in contrast with the correlation between Saccharomyces cerevisiae antibodies and BD as reported in other populations. It seems that environmental factors may contribute to disease expression in different populations, producing different effects according to the individual’s genetic predisposition. Saccharomyces cerevisiae antibodies do not seem to be of any significance in the Greek population.
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( Saad Alrajhi ),( Pascale Germain ),( Myriam Martel ),( Peter Lakatos ),( Talat Bessissow ),( Talal Al-taweel ),( Waqqas Afif ) 대한장연구학회 2020 Intestinal Research Vol.18 No.3
Background/Aims: Latent tuberculosis screening is mandatory prior to initiating anti-tumor necrosis factor (anti-TNF) medications. Guidelines recommend interferon-gamma release assays (IGRA) as first line screening method for the general popula tion. Studies provided conflicting evidence on IGRA and tuberculin skin test (TST) performance in inflammatory bowel disease (IBD) patients. We assessed test concordance and the effects of immunosuppression on their performance in IBD patients. Methods: We searched MEDLINE, Embase and Cochrane databases (2011-2018) for studies testing TST and IGRA in IBD. Pri mary outcome was TST and IGRA concordance. Secondary outcomes were effects of immunosuppressive therapy on perfor mance. Immunosuppression defined as either steroids, thiopurine, methotrexate or cyclosporine use. We used the pooled ran dom effects model to adjust for heterogeneity analyzed using (I2-Q statistics). We compared the fixed model to exclude smaller study effects. Results: Sixteen studies (2,488 patients) were included. Pooled TST and IGRA concordance was 85% (95% con fidence interval [CI], 81%-88%; P=0.01). Effects of immunosuppression were reported in 8 studies (814 patients). The odds ratio of testing positive by IGRA decreased to 0.57 if immunosuppressed (95% CI, 0.31-1.03; P=0.06). The odds ratio of testing positive by TST if immunosuppressed was 1.14 (95% CI, 0.61-2.12; P=0.69). The fixed model yielded similar results, however the negative effect of immunosuppression on IGRA reached statistical significance (P=0.01). Conclusions: While concordance was 85% between TST and IGRA, the performance of IGRA seems to be negatively affected by immunosuppression. Given the importance of detecting latent tuberculosis prior to anti-TNF initiation, further randomized controlled trials comparing the per formance of TST and IGRA in IBD patients are needed. (Intest Res 2020;18:306-314)
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