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Early Cardiac Dysfunction in Biopsy-proven Nonalcoholic Fatty Liver Disease
( Peter C. Johnson ),( Anthony A. Cochet ),( Rosco S. Gore ),( Stephen A. Harrison ),( John P. Magulick ),( James K. Aden ),( Angelo H. Paredes ) 대한소화기학회 2021 대한소화기학회지 Vol.78 No.3
Background/Aims: Nonalcoholic fatty liver disease (NAFLD) encompasses a range of diseases from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) and has been linked to cardiovascular disease and sub-clinical cardiac remodeling. This paper presents a retrospective study of biopsy-proven NAFL and NASH to examine the differences in subclinical cardiac remodeling. Methods: Patients were recruited from an institutional repository of patients with liver-biopsy-confirmed NAFLD. Patients with a transthoracic echocardiogram (TTE) within 12 months of the liver biopsy were included. The parameters of the diastolic dysfunction were reviewed for the differences between NAFL and NASH as well as between the stages and grades of NASH. Results: Thirty-three patients were included in the study, 17 with NAFL and 16 with NASH. The NASH patients were more likely to have lower platelets, higher AST, higher ALT, and higher rates of type 2 diabetes mellitus, coronary artery disease, and hypertension than the NAFL patients. The E/e’ ratio on transthoracic echocardiogram was significantly higher in NASH compared to NAFL, advanced-stage NASH compared to early stage, and high-grade NASH compared to low-grade. The E/e’ ratio was also significantly higher in NASH than NAFL in patients without diabetes mellitus. The presence of diastolic dysfunction trended toward significance. The other markers of diastolic dysfunction were similar. Logistic regression revealed a statistical association with E/e' and NASH. Conclusions: NASH patients had evidence of a higher E/e’ ratio than NAFL, and there was a trend towards a significant diastolic dysfunction. Patients with NASH compared to NAFL should be closely monitored for signs and symptoms of cardiac dysfunction. (Korean J Gastroenterol 2021;78:161-167)
UV Star Formation Rates in the Local Universe
Salim, Samir,Rich, R. Michael,Charlot, Stephane,Brinchmann, Jarle,Johnson, Benjamin D.,Schiminovich, David,Seibert, Mark,Mallery, Ryan,Heckman, Timothy M.,Forster, Karl,Friedman, Peter G.,Martin, D. C IOP Publishing 2007 The Astrophysical journal, Supplement series Vol.173 No.2
Spatiotemporal Evolution of the Primary Glioblastoma Genome
Kim, J.,Lee, I.H.,Cho, H.,Park, C.K.,Jung, Y.S.,Kim, Y.,Nam, S.,Kim, B.,Johnson, Mark D.,Kong, D.S.,Seol, H.,Lee, J.I.,Joo, K.,Yoon, Y.,Park, W.Y.,Lee, J.,Park, Peter J.,Nam, D.H. Cell Press 2015 CANCER CELL Vol. No.
Tumor recurrence following treatment is the major cause of mortality for glioblastoma multiforme (GBM) patients. Thus, insights on the evolutionary process at recurrence are critical for improved patient care. Here, we describe our genomic analyses of the initial and recurrent tumor specimens from each of 38 GBM patients. A substantial divergence in the landscape of driver alterations was associated with distant appearance of a recurrent tumor from the initial tumor, suggesting that the genomic profile of the initial tumor can mislead targeted therapies for the distally recurred tumor. In addition, in contrast to IDH1-mutated gliomas, IDH1-wild-type primary GBMs rarely developed hypermutation following temozolomide (TMZ) treatment, indicating low risk for TMZ-induced hypermutation for these tumors under the standard regimen.