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Myeong Seon Ryu,Jinwon Kim,Su-Ji Jeong,Hee-Jong Yang,Xuan-Hao Wu,Do-Youn Jeong,Sun-Min Park 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, we investigate the bacterial diversity and quality of madetraditionally made doenjang (TMD). The quality of TMD highly depends on the bacterial composition, which ambient bacteria in the environment and production conditions influence, a complete understanding of the bacteria community from different regions is needed. Twenty-nine TMD samples were collected from different regions and its biogenic amine content, bacteria composition, and metabolic function were analyzed. This result suggests that most TMD contained beneficial bacteria and it’s no similarity among the regional groups. Functional profile results showed that histamine contents were lower in CN and CC, and tyramine contents did not differ significantly. In conclusion, TMD mainly contained various Bacillus spp., and the predominant one was B. velezensis, which had antioxidant and fibrinolytic activity regardless of the regional origin. [This work was supported by “Functional identification of Korean traditional soybean products (safety monitoring) project” under the Ministry of Agriculture, Food and Rural Affairs and partly Korea Agro-Fisheries and Food trade corporation in 2021.]
벼 깨씨무늬병 및 잎집썩음병에 항진균 활성을 갖는 길항 미생물의 탐색
류명선 ( Myeong Seon Ryu ),양희종 ( Hee-jong Yang ),정수지 ( Su-ji Jeong ),서지원 ( Ji-won Seo ),정도연 ( Do-youn Jeong ) 한국균학회 2019 韓國菌學會誌 Vol.47 No.3
벼의 깨씨무늬병과 잎집썩음병의 원인균인 Cochliobolus miyabeanus와 Sarocladium oryzae에 의해 발병되며, 깨씨무늬병이 이삭에 발생할 경우Curvularia lunata에 의해 이삭마름병이 추가로 발병하게 되고 한국인의 주식인 쌀의 수확량 감소 및 쌀의 품질 저하와 같은 손실을 초래하여 세계적으로 벼 재배 국가에서는 큰 문제로 장기적으로는 심각한 문제를 초래한다. 따라서, 이러한 식물 병원성 곰팡이의 생물학적 방제를 위해 순창군 논 토양에서 세포외 효소 활성이 우수하고 siderophore를 생산하는 유용 미생물 5종을 선별하였다. 5종의 선별 미생물은 벼의 식물 병원성 곰팡이 3종에 대하여 우수한 항진균 활성을 갖고 있었으며, 특히 JSRB 177 균주는 가장 우수한 활성을 지녀 최종 균주로 선별되었다. 최종 선별된 JSRB 177 균주는 16S rRNA 염기서열 분석을 통하여Bacillus subtilis로 동정되었으며, 최종적으로 JSRB 177의 당 이용성 및 효소 생산에 대한 분석을 통하여 생리학적 특성을 확인하였다. 향후 포트 시험 및 생산 공정 확립 등 산업화에 연관된 추가 연구가 필요하지만 앞선 결과를 토대로 JSRB 177 균주는 벼 병원성 곰팡이에 대한 생물학적 방제를 위한 소재로 높은 활용이 기대된다. Brown spot and sheath rot of rice are caused by fungal pathogens such as Curvularia lunata, Cochliobolus miyabeanus, and Sarocladium oryzae, and cause losses such as reduced rice yield and quality, which is an enormous problem with serious long-term effects. To search biological control agents of phytopathogenic fungi, five kinds of useful Bacillus-like isolates which are excellent in extracellular enzyme activity and produce siderophore were selected from paddy soil of Sunchang in Korea. The selected isolates were tested for excellent antifungal activity against three of the phytopathogenic fungi that frequently occur in rice, and JSRB 177 strain had the most excellent antifungal activity. Based on the experimental results, JSRB 177 is finally selected as a candidate for biological control and identified to Bacillus subtilis through 16S rRNA sequence analysis. In addition, physiological characteristics of JSRB 177 confirmed by analysis of carbohydrate fermentation patterns and enzyme production ability. Based on the above results, JSRB 177 is expected to be used as a biological control agent for the rice pathogenic fungi. In the future, further studies related to industrialization such as port test and establishment of mass production process are needed.
Plasma Osteopontin Is a Useful Diagnostic Biomarker for Advanced Non-Small Cell Lung Cancer
( Seon Sook Han ),( Seung Joon Lee ),( Woo Jin Kim ),( Dong Ryeol Ryu ),( Jun Yeon Won ),( Shin Young Park ),( Myeong Ju Cheon ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.3
Background: Osteopontin (OPN) and carbonic anhydrase IX (CAIX), which are expressed on the surface of tumor cells, are associated with hypoxia during tumor development and progression. However, the roles of these proteins in the plasma of patients with non-small cell lung cancer (NSCLC) are poorly understood. Herein, we hypothesized that plasma OPN and CAIX levels could be used as diagnostic and prognostic tumor markers in patients with NSCLC. Methods: Fifty-three patients with NSCLC and 50 healthy control subjects were enrolled. We selected controls without malignancy and matched them with NSCLC patient cases according to age and gender. Blood samples were collected at the time of diagnosis; the plasma levels of OPN and CAIX were measured by enzyme-linked immunosorbent assays. Results: The plasma levels of OPN in the patients with NSCLC were significantly elevated as compared to those in the controls (p=0.016). However, there was no difference in the plasma level of CAIX between the NSCLC patients and controls. NSCLC patients with a distant metastasis had a remarkable increase in plasma OPN compared with patients without metastasis (p=0.026), but no such correlation was found for CAIX. There was no difference in overall survival rates according to the plasma level of OPN between the two groups (by Kaplan-Meier survival analysis). Conclusion: Plasma OPN levels were elevated in patients with NSCLC as compared with the controls, with greater elevation of OPN levels in the advanced stages of disease. Therefore, plasma OPN may have utility as a diagnostic, but not prognostic, biomarker of advanced NSCLC.
뇌파분석을 통한 군복무 부적응 병사의 뇌기능 특징 연구
류명오(Ryu, Myeong-Oh),이선규(Yi, Seon-Gyu),백기자(Bak, Ki-Ja) 한국산학기술학회 2014 한국산학기술학회논문지 Vol.15 No.4
본 연구는 뇌파 분석을 통해 군복무 부적응 병사의 뇌기능 특징을 알아보고자 진행하였다.대상자는 00사단 비전캠 프에 입소한 병사 59명과 정상적으로 복무중인 병사 60명,그리고 민간청년 1,000명 등 총 1,119명이다.군인에 대한 뇌파 측정은 2013년 9월부터 2014년 1월까지 실시하였다.연구결과 첫째,민간청년과 군인 집단 간 뇌기능 비교에서 기초율동·주 의·정서·항스트레스·브레인지수는 군인 집단이 유의하게 높았으며,자기조절·활성·좌우뇌균형지수는 민간청년 집단이 유의 하게 높았다.둘째,군복무 부적응 병사와 정상 병사 집단 간에는 정서지수와 브레인지수에서 유의한 차이로 부적응 집단이 낮았으며,평균값도 모든 뇌기능지수에서 부적응 집단이 낮은 값을 나타냈다.이 연구 결과 규칙적인 생활과 신체활동,균형 잡힌 영양섭취를 하는 군 복무는 정상 또는 부적응 병사를 막론하고 뇌기능에 긍정적인 영향을 주지만,그러한 부대활동에 서 대부분 열외 되는 부적응 병사는 영향을 덜 받는 것으로 사료된다. This study focuses on observing the brain function characteristics of maladaptive soldiers, through EEG analysis. The number of subjects was 1,119 including 59 maladaptive soldiers, 60 normal soldiers and 1,000 civil youths. The EEG measurements were performed from Sep. 2013 to Jan. 2014. As a result of the study, first, the soldier group's BRQ, ATQ, EQ, ASQ and BQ values were significantly higher than civil youth's, on the contrary to SRQ, ACQ, CQ which were higher in civil youth group. Second, compared to normal soldiers, the values of EQ and BQ were meaningfully low in maladaptive soldiers group, as well as the average values of each 8 quotient. In conclusion, military service can be assumed to have a positive effect on brain function of all soldiers due to regular life cycle, usual physical activities and balanced nutrition, but less effect on maladaptive soldiers who are exempted from those strict life.
Plasma Osteopontin Is a Useful Diagnostic Biomarker for Advanced Non-Small Cell Lung Cancer
Han, Seon-Sook,Lee, Seung-Joon,Kim, Woo Jin,Ryu, Dong Ryeol,Won, Jun Yeon,Park, Shinyoung,Cheon, Myeong Ju The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.3
Background: Osteopontin (OPN) and carbonic anhydrase IX (CAIX), which are expressed on the surface of tumor cells, are associated with hypoxia during tumor development and progression. However, the roles of these proteins in the plasma of patients with non-small cell lung cancer (NSCLC) are poorly understood. Herein, we hypothesized that plasma OPN and CAIX levels could be used as diagnostic and prognostic tumor markers in patients with NSCLC. Methods: Fifty-three patients with NSCLC and 50 healthy control subjects were enrolled. We selected controls without malignancy and matched them with NSCLC patient cases according to age and gender. Blood samples were collected at the time of diagnosis; the plasma levels of OPN and CAIX were measured by enzyme-linked immunosorbent assays. Results: The plasma levels of OPN in the patients with NSCLC were significantly elevated as compared to those in the controls (p=0.016). However, there was no difference in the plasma level of CAIX between the NSCLC patients and controls. NSCLC patients with a distant metastasis had a remarkable increase in plasma OPN compared with patients without metastasis (p=0.026), but no such correlation was found for CAIX. There was no difference in overall survival rates according to the plasma level of OPN between the two groups (by Kaplan-Meier survival analysis). Conclusion: Plasma OPN levels were elevated in patients with NSCLC as compared with the controls, with greater elevation of OPN levels in the advanced stages of disease. Therefore, plasma OPN may have utility as a diagnostic, but not prognostic, biomarker of advanced NSCLC.