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- 저자 : ( Mustafa Çelebier ) (검색결과 4 건)
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Betül Çelebi-Saltik,Zeynep Haciomeroglu,Didem Kart,Hasan Hüseyin Ünal,Mustafa Özgür Öteyaka 한국섬유공학회 2022 Fibers and polymers Vol.23 No.11
Tissue engineering strategies include successful management of bone injuries with biomaterials to develop bonelikestructures. The production of natural biomaterials for this purpose helps both to ensure tissue integrity and to presentalternative products for clinical purposes. However, natural materials are mostly used together with synthetic or metallicmaterials due to their low stability and mechanical properties for bone tissue regeneration. There is a clinical need formaterial combinations that have both antimicrobial properties and the ability to increase osteogenic induction. This workaims to fabricate a nanofiber scaffold using polyurethane (PU) loaded with natural fish head powder (FHP) fromArgyrosomus regius species and copper (II) chloride (CuCl2) using the electrospinning technique in order to respond to thisclinical need. There has not been any material combination in the literature that contains these compounds, supports bonedifferentiation of stem cells, and prevents bacterial adhesion. To evaluate our composite materials morphology, chemicalstructure, wettability, and thermal analysis were studied with different techniques. Anti-adhesive properties of theStreptococcus mitis (S. mitis) on composite materials were tested with bacterial colonization, and osteogenic inductiveproperties by human bone marrow mesenchymal stem cells (hBMSCs) with and without osteogenic differentiation mediumwere performed with cell viability assay, Alizarin Red staining, Ca deposition and SEM analysis. According to FESEM-EDSand ATR_FTIR data, the additives were highly incorporated into the PU nanofibers. The produced materials had randomlyoriented nanofiber with a porosity of ~72 %. The FHP loaded nanofiber had an average diameter of ~185 nm. The swellingbehavior of FHP-loaded PU roughly decreased for 3, 5, and 7 days due to the hydrophobic character of the sample. Anincreasing percentage of FHP decreased the bacterial colonization of S. mitis. PUn-CuCl2-FHP nanofibers did not exhibit anycytotoxic effect on the hBMSCs. According to Alizarin Red Staining and Ca deposition analysis, stimulation with both thematerial and the osteogenic medium triggered the bone differentiation of the hBMSCs in a combined manner at days-14. Based on the results, it can be deduced that natural fish head is a promising additive material for fabricating bone-likebiomaterials.
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Erinç Uludamar,Mustafa Taş,Sami Gökberk Biçer,Cihan Yıldırım,Ebru Aykut Yıldırım,Kerimcan Çelebi 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.2
The connection surfaces of drag-link must be tough and safe enough to carry transmitted forces that exert on the product in service conditions. Therefore, undulated forming takes place in machining process to stay the rod-ends in the rod. In the rod-end, after forming process, a straight part which remains on the body causes extra cost and weight on the product. In this study, the result of shortening of rod-end which was produced from C45+N quality steel was investigated by comparing with the unmodified rod-end. The comparison was carried out by fatigue test and Finite Element Analysis. The results showed that the cropped part has almost no effect on the durability of the product. It is measured that the modification result with 0,082 kg weight reduction on each rod-end and 5 seconds shortening of machining process were observed by the modification on rod-end. The effect of modification on the part was examined in a case study. The case study indicated that annual expenses of raw material lowered by $9.124,56 and total cost decreased by $11.480,20.
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Evaluation of Recent Data Processing Strategies on Q-TOF LC/MS Based Untargeted Metabolomics
( Ozan Kaplan ),( Mustafa Çelebier ) 한국질량분석학회 2020 Mass spectrometry letters Vol.11 No.1
In this study, some of the recently reported data processing strategies were evaluated and modified based on their capabilities and a brief workflow for data mining was redefined for Q-TOF LC-MS based untargeted metabolomics. Commercial pooled human plasma samples were used for this purpose. An ultrafiltration procedure was applied on sample preparation. Sample set was analyzed through Q-TOF LC/MS. A C18 column (Agilent Zorbax 1.8 μM, 50 × 2.1 mm) was used for chromatographic separation. Raw chromatograms were processed using XCMS - R programming language edition and Isotopologue Parameter Optimization (IPO) was used to optimize XCMS parameters. The raw XCMS table was processed using MS Excel to find reliable and reproducible peaks. Totally 1650 reliable and reproducible potential metabolite peaks were found based on the data processing procedures given in this paper. The redefined dataset was upload into MetaboAnalyst platform and the identified metabolites were matched with 86 metabolic pathways. Thus, two list were obtained and presented in this study as supplement files. The first list is to present the retention times and m/z values of detected metabolite peaks. The second list is the metabolic pathways related with the identified metabolites. The briefly described data processing strategies and dataset presented in this study could be beneficial for the researchers working on untargeted metabolomics for processing their data and validating their results.
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Ozan Kaplan,Nagehan Saltan,Arzu Köse,Yavuz Bülent Köse,Mustafa Çelebier 사단법인 한국질량분석학회 2023 Mass spectrometry letters Vol.14 No.2
Carthamus tinctorius L. (known as safflower) is a valuable oil plant whose importance is increasing rapidly in the world due to its high adaptation to arid regions. The seeds of this unique plant are especially used in edible oil, soap, paint, varnish and lacquer production. Its flowers are used in vegetable dye production and medicinal purposes beside its features as a coloring and flavoring in food. After the oil is removed, the remaining pulp and plant parts are used as animal feed, and dry straw residues are used as fuel. Beside all these features, its usage as a herbal medicinal plants for various diseases has gained importance on recent years. In this study, it was designed a plant metabolomic approach which transfers all the recent data processing strategies of untargeted metabolomics in clinical applications to the present study. Q-TOF LC/MS-based analysis of the extracts (70% ethanol, hexane, and chloroform) for both seed and flowers was performed using a C18 column (Agilent Zorbax 1.8 µM, 100 × 2.1 mm). Differences were observed in seed and fruit extracts and these differences were visualized using principal component analysis (PCA) plots. The total number and intersections of the peaks in the extracts were visualized using peak count comparison graph. Based on the experimental results, the number of the detected peaks for seeds was higher than the ones for the flowers for all solvent systems to extract the samples.
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