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1P-208 Silver Nanoparticles embedded in polyaspartamide-based hydrogels for biomedical applications
김지흥,( Wang Bo ),( Milene Tan ),( K. M. Fromm ) 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
The increased use of medical devices combined with the emergence of new multi-drug resistant bacteria has focused the research on biomaterials-related infections. Silver has already been proven to be effective against bacterial infections even at low concentration (0.1-10 ppm). Furthermore, it has been demonstrated that nano-particulate (NP) silver could be even more efficient due to a better interaction with bacteria and a long-lasting activity compared to ionic silver. Polyaspartamides are very promising for biomedical applications owing to their water-solubility, nontoxicity, nonantigenicity, and biodegradability. In this work, DOPA-conjugated polyaspartamide was synthesized and used to prepare the crosslinked gel via catechol-boron coordinative interactions. The adsorbed silver ion onto the remaining catechol moieties within the gel matrix will be reduced in-situ by redox process to provide the silver NP-embedded hydrogel.