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      • KCI등재

        Effect of Foeniculum Vulgare (Fennel) on Sleep Quality of Menopausal Women: A Double-blinded, Randomized Placebo-controlled Trial

        Maliheh Afiat,Fatemeh Rajab Dizavandi,Leila Kargarfard,Seyede Houra mosavi Vahed,Masumeh Ghazanfarpour 대한폐경학회 2018 대한폐경학회지 Vol.24 No.3

        Objectives: Aim of present study was designed to investigate the soporific effect of fennel among menopausal women.Methods: The present double–blinded and placebo-controlled trial examined the fennel effect on Pittsburgh Sleep Quality Index (PSQI). Total score and relevant 7 components, including sleep duration, sleep latency, use of sleeping medication, subjective sleep quality, sleep disturbances, daytime dysfunction and habitual sleep efficiency among 50 menopausal women compared to control group within a 12-week follow-up. Results: The patients in both groups reported no certain side effects and all subjects completed the study. The mean actual sleep duration was 5 hours and 66 minutes. Intergroup comparison revealed no statistically significant differences in the mean total PSQI score (P = 0.439), subjective sleep quality (P = 0.826), habitual sleep efficiency (P = 0.127), sleep disturbances (P = 0.130), use of sleeping medication (P = 0.52) and daytime dysfunction (P = 0.439). A tendency toward significant between 2 groups was seen concerning the sleep duration (P = 0.059). Intergroup comparison showed significantly borderline levels (P = 0.059). Conclusions: The treatment of 12 weeks with fennel caused a slight effect that did not reach to significant. These findings should be considered cautiously because of small sample size, short-term follow-up and subjective measure of sleep quality.

      • KCI등재

        The Effect of Short-term Treatment with Fennel on Lipid Profile in Postmenopausal Women: A Randomized Controlled Trial

        ( Maliheh Afiat ),( Elham Amini ),( Masumeh Ghazanfarpour ),( Bahareh Nouri ),( Mahsa Sadat Mousavi ),( Masoudeh Babakhanian ),( Hassan Rakhshandeh ) 대한폐경학회 2018 대한폐경학회지 Vol.24 No.1

        Objectives: The present trial aimed to assess the effects of Fennel (Foeniculum vulgare Mill.) on lipid profiles. Methods: In this double blind, randomized and placebo-controlled trial, sixty eligible postmenopausal women were randomly assigned into the fennel and placebo groups. Total blood cholesterol, cholesterol fractions, and triglycerides were tested at the baseline, and after three-month follow-up. Results: There was no significant difference in triglyceride (P = 0.679), total cholesterol (P = 0.103), low-density lipoprotein cholesterol (LDL-C; P = 0.146) and high-density lipoprotein cholesterol (HDL-C; P = 0.266) levels between the two groups. In addition, in both groups, a paired t-test showed no significant difference in all mentioned parameters, except for HDL-C, indicating significant borderline improvement (P = 0.052) in the fennel group. Conclusions: The fennel group revealed a very slight positive change in LDL-C, triglyceride and HDL-C. Further studies with longer durations, higher doses, and larger sample sizes are recommended to validate the results. (J Menopausal Med 2018;24:29-33)

      • KCI등재

        The Effect of Foeniculum Vulgare (Fennel) on Body Composition in Postmenopausal Women with Excess Weight: A Double-blind Randomized Placebo-controlled Trial

        ( Nafiseh Saghafi ),( Masumeh Ghazanfarpour ),( Talat Khadivzadeh ),( Masoudeh Babakhanian ),( Maliheh Afiat ) 대한폐경학회 2017 대한폐경학회지 Vol.23 No.3

        Objectives: The goal of this study was to evaluate the effect of fennel on body composition. Methods: This study is a secondary analysis of a double-blind, randomized, placebo-controlled trial. Fifty-four out of 60 patients were able to successfully complete the original study. Seven out of 54 patients were excluded because they were not overweight and obese. Thus, 47 women were included in this secondary analysis. Of these 47 women, 22 were in the fennel group and 25 were in placebo group. Body weight, body mass index (BMI) as well as fat distribution was measured at the baseline and after a three-month follow-up. Results: Comparison of fennel and placebo groups did not reveal any significant effect in terms of body weight, BMI, waist and hip circumferences and fat distribution. Also, the results of paired t-test did not variation of these parameters across groups before and after 12-week treatment. Conclusions: Menopausal women in fennel group experienced a slight increase in body weight and fat distribution, which was not significant. Further studies with larger sample sizes are recommended to validate the results of this study. (J Menopausal Med 2017;23:166-171)

      • KCI등재

        The Effect of Short-term Treatment with Fennel on Bone Density in Postmenopausal Women: A Randomized Controlled Trial

        ( Masumeh Ghazanfarpour ),( Elham Amini ),( Talat Khadivzadeh ),( Masoudeh Babakhanian ),( Bahareh Nouri ),( Hassan Rakhshandeh ),( Maliheh Afiat ) 대한폐경학회 2017 대한폐경학회지 Vol.23 No.2

        Objectives: The goal of this study is to assess the effect of fennel on bone density. Methods: This was a double-blind, randomized, placebo-controlled trial, which studied sixty eligible postmenopausal women, who were randomly assigned to fennel and placebo groups. Then, the dual energy X-ray absorptiometry was utilized to measure bone mineral density (BMD) and bone mineral content (BMC) of the spine, femoral neck, intertrochanter, and trochanter at the baseline and after three-month follow-up. Results: The mean BMD and BMC at lumbar spine (P = 0.14, P = 0.504), total hip femoral (P = 0.427, P = 0.471), trochanter (P = 0.075, P = 0.07), intertrochanter, (P = 0.864, P = 0.932) and femoral neck (P = 0.439, P = 0.641) was not significantly different between the fennel and placebo groups. Conclusions: The results of this study did not approve the effect of fennel on bone density in post-menopausal women. However, to gain deeper insights, further studies with longer durations and larger sample sizes are recommended. (J Menopausal Med 2017;23:124-130)

      • KCI등재

        Overview of the Effect of Herbal Medicines and Isoflavones on the Treatment of Cognitive Functio

        ( Nasibeh Roozbeh ),( Reyhaneh Kashef ),( Masumeh Ghazanfarpour ),( Leila Kargarfard ),( Leili Darvish ),( Talat Khadivzadeh ),( Fatemeh Rajab Dizavandi ),( Maliheh Afiat ) 대한폐경학회 2018 대한폐경학회지 Vol.24 No.2

        Objectives: The current overview aimed to present the effect of herbal medicines on cognitive function among menopausal women. Methods: Two separate authors performed systematic search of the 3 databases of (the MEDLINE Scopus and the Cochrane Central Register Trials) from inception to January 2018. Methodological quality of each study was assessed using the AMSTAR. Results: According to 2 reviews, soy seems to be effective in enhancing summary cognitive function and visual memory. The effect of isoflavones on cognition was affected by treatment duration as six weeks of treatment improved some dimensions of cognitive parameters, including mental flexibility and planning, and longer treatment period (6 months) improved category digit span test, digit symbol test, and visual scanning test score. The effect of phytoestrogen on cognitive function of menopausal women might be altered age, gender, ethnicity, menopausal status, dosage, and length of treatment, types of cognitive test, location, types of soy, and types of phytoestrogen. Combination of Gingko with ginseng could not improve sustained attention, episode memory, category generation or frontal lobe function. Gingko biloba had no significant effect on planning, memory and sustained attention, except for its limited effect on mental flexibility in late menopause. In addition, other herbal medicines like black cohosh showed no effective beneficial. Conclusions: Phytoestrogen, soy and isoflavones might have a limited beneficial effect on some aspects of cognition. The phytoestrogens affecting cognition might be modified by age, gender, ethnicity, menopausal status, dosage, and length of treatment, types of cognitive test, location, types of soy, and types of phytoestrogen. (J Menopausal Med 2018;24:113-118)

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