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( Yihunie Ayele ),( Jung Ah Kim ),( Eun Hee Park ),( Ye Jung Kim ),( Negussie Retta ),( Gulelat Dessie ),( Sang Ki Rhee ),( Kwangoh Koh ),( Kung Woo Nam ),( Hee Seon Kim ) 한국응용약물학회 2013 Biomolecules & Therapeutics(구 응용약물학회지) Vol.21 No.2
This study examined the eoeal polyphenol content of eight wild edible from Ethiopia and their effect on NO production in Raw264. 7 cells. Owing to its relatively high polyphenol con and inhibition of NO production, the methanol extract of Ad-ansonia digitata L. leaf (MEAD) was subjected to detailed evaluation of its antioxidant and anti-inflammatoryeffcts. Antioxidant effects were assessed by measuring free-radical-scavenging activity using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and oxygen-radical-absorbance capacity (ORAC) assays, while anti-inflammatory effects were assessed by measuring inducible nitric oxide synthase (iNOS) expression in lipopolysaccharide (LPS)-stimulated RAW264. 7 cells. ln the ORAC assay, Mead was 10. 2 times more potent than vitamin C at eliminatinf peroxyl radicals. ln DPPH assay, MEAD inhibited lkBa degradation and NF-kB trans-location from the cytosol to the nucleus in LPS-inflammatory iNOS expression, which might be related to the elimination of peroxyl radicals amd thus the inhibition of lkBa-mediated NF-kB signal transduction.