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The Cytotoxic Action of New Ag-Porphyrin as a Potential Chemotherapeutic Agent
Babayan Nelli,Tovmasyan Artak,Gevorkyan Ani,Gasparyan Gennadi,Aroutiounian Rouben 한국환경생물학회 2008 환경생물 : 환경생물학회지 Vol.26 No.2
- Earlier we have described new water-soluble Ag-and Zn-derivatives of tetrachloridemeso-tetra(4-N-oxiethylpyridyl) porphyrin(TOEtPyP) as potential anticancer drugs. In this workthe effect of one of these metal porphyrins, TOEtPyP Ag, on the cell population kinetics was stu-died in vitrousing morphological and biochemical techniques. The results suggested thatTOEtPyP Ag action consisted in the simultaneous suppression of the cell growth and activation ofthe cell death. About 40% of the cells were shown to die via apoptotic pathway. So, the porphyrinstudied may be attributed to inducers of both necrotic and apoptotic processes. The results ob-tained support our previous assertion that TOEtPyP Ag may be considered as a potential che-motherapeutic agent.