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      • Pattern of Liver Enzymes in Alcohol Dependence Syndrome Patients

        ( Mithileshwer Raut ),( Binod Kumar Yadav ),( Vijay Kumar Sharma ),( Eans Tara Tuladhar ),( Aseem Bhattarai ),( Bharat Jha ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

        Aims: Alcohol dependence syndrome (ADS) has become a global public health challenge because of its high prevalence and the concomitant increase in risk of liver disease, cardiovascular disease and premature death. Influence of alcohol use on liver metabolism is well recognized. This study was aimed at examining the association of liver enzymes like γ-glutamyltransferase (GGT) and aminotransferase, with alcohol dependence syndrome patients. Methods: This cross-sectional study was conducted in Tribhuvan University Teaching Hospital. ADS patients were screened by the consultant psychiatrist using the Alcohol Use Disorder Identification Test (AUDIT) questionnaire. A total of 89 patients scored positive on the AUDIT as having alcohol-related problems and were included in the study. Blood Pressure and other anthropometric parameters were measured while blood samples were analyzed for liver enzymes and serum protein. Results: Mean age of cases and controls was 35.42 ± 5.6 & 34.53 ± 3.5 years respectively. The mean values of Gamma GT, SGOT and SGPT were largely elevated in cases as compared to the controls with a statically significance (P<0.001). Among the ADS cases serum GGT level was elevated in 97% patients. The SGOT/SGPT ratio was also significantly higher in cases (2.02 ± 0.39) and control (1.45±0.62). It was found that 15.1 % cases had low serum protein level and 32.9% cases were low serum albumin level. Albumin to globulin ratio was also significantly decreased in cases (1.16 ±0.29). Conclusions: These findings support the hypothesis that, alcohol may affect the pattern of liver enzymes and also damage the liver cells. Decrease in serum albumin and elevation of SGOT to SGPT ratio more than two is suggestive of development of liver cirrhosis in alcohol dependence patients.

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