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- 저자 : ( Ding Yonghui ) (검색결과 2 건)
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Field monitoring of the train-induced hanger vibration in a high-speed railway steel arch bridge
Youliang Ding,Yonghui An,Chao Wang 국제구조공학회 2016 Smart Structures and Systems, An International Jou Vol.17 No.6
Studies on dynamic characteristics of the hanger vibration using field monitoring data are important for the design and evaluation of high-speed railway truss arch bridges. This paper presents an analysis of the hanger\'s dynamic displacement responses based on field monitoring of Dashengguan Yangtze River Bridge, which is a high-speed railway truss arch bridge with the longest span throughout the world. The three vibration parameters, i.e., dynamic displacement amplitude, dynamic load factor and vibration amplitude, are selected to investigate the hanger\'s vibration characteristics in each railway load case including the probability statistical characteristics and coupled vibration characteristics. The influences of carriageway and carriage number on the hanger\'s vibration characteristics are further investigated. The results indicate that: (1) All the eight railway load cases can be successfully identified according to the relationship of responses from strain sensors and accelerometers in the structural health monitoring system. (2) The hanger\'s three vibration parameters in each load case in the longitudinal and transverse directions have obvious probabilistic characteristics. However, they fall into different distribution functions. (3) There is good correlation between the hanger\'s longitudinal/transverse dynamic displacement and the main girder\'s transverse dynamic displacement in each load case, and their relationships are shown in the hysteresis curves. (4) Influences of the carriageway and carriage number on the hanger\'s three parameters are different in both longitudinal and transverse directions; while the influence on any of the three parameters presents an obvious statistical trend. The present paper lays a good foundation for the further analysis of train-induced hanger vibration and control.
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Upregulation of Fas in epithelial ovarian cancer reverses the development of resistance to Cisplatin
( Fan Yang ),( Wang Long ),( Han Xuechuan ),( Liu Xueqin ),( Ma Hongyun ),( Ding Yonghui ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.1
This study was to investigate the role of Fas in the developmentof Cisplatin-resistant ovarian cancer. On the cellularlevel, Fas expression was significantly reduced in Cisplatinresistant A2780 (A2780/CP) cells compared with A2780 cells. Fas silence with siRNA would promote tumor cell linesproliferation, facilitate tumor cell cycle transition of G1/S,prevent cell apoptosis, and promote cell migration. Expressionof drug resistance gene was negatively correlated to Fas. Innude mice metastasis model of human ovarian carcinoma bysubcutaneous transplantation, after Ad-Fas injected intratumorly,we found that upregulation of Fas could inhibit transplantationtumor tissue growth and reduce the expression of drugresistance gene. Our results indicated that upregulation of Fasin epithelial ovarian cancer reversed the development ofresistance to Cisplatin. In conclusion, our findings suggestedthat Fas might act as a promising therapeutic target for improvementof the sensibility to Cisplatin in ovarian cancer.
ScienceON
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