http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Brian Henry ) (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Mechanical robustness of AREVA NP's GAIA fuel design under seismic and LOCA excitations
Brian Painter,Brett Matthews,Pierre-Henri Louf,Herve Lebail,Veit Marx 한국원자력학회 2018 Nuclear Engineering and Technology Vol.50 No.2
Recent events in the nuclear industry have resulted in a movement towards increased seismic and LOCAexcitations and requirements that challenge current fuel designs. AREVA NP's GAIA fuel design introducesunique and robust characteristics to resist the effects of seismic and LOCA excitations. For demanding seismic and LOCA scenarios, fuel assembly spacer grids can undergo plastic deformations. These plastic deformations must not prohibit the complete insertion of the control rod assembliesand the cooling of the fuel rods after the accident. The specific structure of the GAIA spacer gridproduces a unique and stable compressive deformation mode which maintains the regular array of thefuel rods and guide tubes. The stability of the spacer grid allows it to absorb a significant amount ofenergy without a loss of load-carrying capacity. The GAIA-specific grid behavior is in contrast to the typical spacer grid, which is characterized by abuckling instability. The increased mechanical robustness of the GAIA spacer grid is advantageous inmeeting the increased seismic and LOCA loadings and the associated safety requirements. The uniqueGAIA spacer grid behavior will be incorporated into AREVA NP's licensed methodologies to take fullbenefit of the increased mechanical robustness
-
Jung Ho Lee,Brian H Lee,Soyoung Jeong,Christine Suh-Yun Joh,Hyo Jeong Nam,Hyun Seung Choi,Henry Sserwadda,Ji Won Oh,Chung-Gyu Park,Seon-Pil Jin,Hyun Je Kim Korea Genome Organization 2023 Genomics & informatics Vol.21 No.2
Immunologists have activated T cells in vitro using various stimulation methods, including phorbol myristate acetate (PMA)/ionomycin and αCD3/αCD28 agonistic antibodies. PMA stimulates protein kinase C, activating nuclear factor-κB, and ionomycin increases intracellular calcium levels, resulting in activation of nuclear factor of activated T cell. In contrast, αCD3/αCD28 agonistic antibodies activate T cells through ZAP-70, which phosphorylates linker for activation of T cell and SH2-domain-containing leukocyte protein of 76 kD. However, despite the use of these two different in vitro T cell activation methods for decades, the differential effects of chemical-based and antibody-based activation of primary human T cells have not yet been comprehensively described. Using single-cell RNA sequencing (scRNA-seq) technologies to analyze gene expression unbiasedly at the single-cell level, we compared the transcriptomic profiles of the non-physiological and physiological activation methods on human peripheral blood mononuclear cell-derived T cells from four independent donors. Remarkable transcriptomic differences in the expression of cytokines and their respective receptors were identified. We also identified activated CD4 T cell subsets (CD55<sup>+</sup>) enriched specifically by PMA/ionomycin activation. We believe this activated human T cell transcriptome atlas derived from two different activation methods will enhance our understanding, highlight the optimal use of these two in vitro T cell activation assays, and be applied as a reference standard when analyzing activated specific disease-originated T cells through scRNA-seq.
-
Fiscal Consolidation: An Exercise in the Methodology of Coordination
( Guglielmo Maria Caporale ),( Michael Chui ),( Stephen G. Hall ),( Brian Henry ) 세종대학교 경제통합연구소 2005 Journal of Economic Integration Vol.20 No.1
This paper outlines a new methodology for the study of international policy coordination, which builds on two separate approaches previously used in the literature: optimal simple rules, and game-theoretic analysis. The new approach is illustrated by using the example of a changed target for the debt-income ratio in the G-3. The results suggest that there are few policy externalities when only fiscal policy is coordinated, whilst coordination of both fiscal and monetary policy results in substantial externalities and welfare improvements. Our findings reflect the fact that, unlike earlier studies, we focus on the strategic interaction between (domestic) policy makers, as well as the standard exchange rate and interest rate transmission mechanisms.
-
Xue Peng,Hu Xiangxiang,Chang Emily,Wang Lufei,Chen Minghui,Wu Tai-Hsien,Lee Dong-Joon,Foster Brian L.,Tseng Henry C.,Ko Ching-Chang 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Abnormally increased resorption contributes to bone degenerative diseases such as Paget’s disease of bone (PDB) through unclear mechanisms. Recently, the optineurin (OPTN) gene has been implicated in PDB, and global OPTN knockout mice ( Optn −/− ) were shown to exhibit increased formation of osteoclasts (osteoclastogenesis). Growing evidence, including our own, has demonstrated that intracellular reactive oxygen species (ROS) stimulated by receptor activator of nuclear factor kappa-B ligand (RANKL) can act as signaling molecules to promote osteoclastogenesis. Here, we report that OPTN interacts with nuclear factor erythroid-derived factor 2-related factor 2 (NRF2), the master regulator of the antioxidant response, defining a pathway through which RANKL-induced ROS could be regulated for osteoclastogenesis. In this study, monocytes from Optn −/− and wild-type ( Optn +/+ ) mice were utilized to differentiate into osteoclasts, and both qRT-PCR and tartrate-resistant acid phosphatase (TRAP) staining showed that the Optn −/− monocytes exhibited enhanced osteoclastogenesis compared to the Optn +/+ cells. CellROX ® staining, qRT-PCR, and Western blotting indicated that OPTN deficiency reduced the basal expression of Nrf2 , inhibited the expression of NRF2-responsive antioxidants, and increased basal and RANKL-induced intracellular ROS levels, leading to enhanced osteoclastogenesis. Coimmunoprecipitation (co-IP) showed direct interaction, and immunofluorescence staining showed perinuclear colocalization of the OPTN-NRF2 granular structures during differentiation. Finally, curcumin and the other NRF2 activators attenuated the hyperactive osteoclastogenesis induced by OPTN deficiency. Collectively, our findings reveal a novel OPTN-mediated mechanism for regulating the NRF2-mediated antioxidant response in osteoclasts and extend the therapeutic potential of OPTN in the aging process resulting from ROS-triggered oxidative stress, which is associated with PDB and many other degenerative diseases.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
