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        Eugenol-rich Fraction of Syzygium aromaticum (Clove) Reverses Biochemical and Histopathological Changes in Liver Cirrhosis and Inhibits Hepatic Cell Proliferation

        Shakir Ali,Amena Mahmood,Indusmita Routray,Tijjani Salihu Shinkafi,Kazim Sahin,Omer Kucuk 대한암예방학회 2014 Journal of cancer prevention Vol.19 No.4

        Background:Dried flower bud of Syzygium aromaticum (clove) is rich in eugenol, an antioxidant and antiinflammatory compound thatcan protect liver against injury. Clove, besides eugenol, also contains other pharmacologically active phytochemicals such as β-sitosteroland ascorbic acid. This study reports the effect of eugenol-rich fraction (ERF) of clove on liver cirrhosis induced by thioacetamide. Methods:Cirrhosis of the liver, which predisposes to hepatocellular carcinoma, was induced by administering thioacetamide (0.03%)in drinking water for 16 weeks. Cirrhotic animals were divided into two groups; the treated group was administered ERF for 9 weeks,one week after discontinuation of thioacetamide, while the other group received normal saline for a similar duration of time. Results:The treatment with ERF, as determined by histopathology and through a battery of biochemical markers of hepatic injury, oxidativestress and drug metabolizing enzymes, significantly ameliorated the signs of liver cirrhosis. It lowered the elevated levels ofalkalinephosphatase, γ-glutamyl transferase and other biochemical changes in liver cirrhosis. Histopathology of the liver corroborated the effectof ERF with biochemical findings. ERF treatment further inhibited cell proliferation, as demonstrated by reduced [3H]-thymidine uptake. Conclusions:Data provide evidence supporting the protective action of ERF on liver cirrhosis. The study assumes significance becausecirrhosis predisposes the liver to cancer, which is characterized by abnormal cell proliferation. ERF in this study is reportedto inhibithepatic cell proliferation and at the same time decrease oxidative stress, which might be the mechanism of protection against liver cirrhosis.

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        Detection Copy-Move Forgery in Image Via Quaternion Polar Harmonic Transforms

        ( Salam A. Thajeel ),( Ali Shakir Mahmood ),( Waleed Rasheed Humood ),( Ghazali Sulong ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.8

        Copy-move forgery (CMF) in digital images is a detrimental tampering of artefacts that requires precise detection and analysis. CMF is performed by copying and pasting a part of an image into other portions of it. Despite several efforts to detect CMF, accurate identification of noise, blur and rotated region-mediated forged image areas is still difficult. A novel algorithm is developed on the basis of quaternion polar complex exponential transform (QPCET) to detect CMF and is conducted involving a few steps. Firstly, the suspicious image is divided into overlapping blocks. Secondly, invariant features for each block are extracted using QPCET. Thirdly, the duplicated image blocks are determined using k-dimensional tree (kd-tree) block matching. Lastly, a new technique is introduced to reduce the flat region-mediated false matches. Experiments are performed on numerous images selected from the CoMoFoD database. MATLAB 2017b is used to employ the proposed method. Metrics such as correct and false detection ratios are utilised to evaluate the performance of the proposed CMF detection method. Experimental results demonstrate the precise and efficient CMF detection capacity of the proposed approach even under image distortion including rotation, scaling, additive noise, blurring, brightness, colour reduction and JPEG compression. Furthermore, our method can solve the false match problem and outperform existing ones in terms of precision and false positive rate. The proposed approach may serve as a basis for accurate digital image forensic investigations.

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