The relationship between serum vitamin D levels and clinical characteristics in chronic urticaria : 만성 두드러기 환자에서의 혈청 비타민 D 수치와 임상적 특징과의 연관성

다국어 초록 (Multilingual Abstract)

Background: Chronic urticaria is defined as the development of daily repeated episodes of itchy wheal and flare lasting for 6 weeks or longer. Owing to its chronic nature and intractable course, it impairs the patients’ quality of life and causes a high burden. However, the exact etiology of chronic urticaria still remains unclear. Nowadays a matter of great interest is on the role of vitamin D in various chronic diseases such as malignancies, infectious diseases, cardiovascular diseases and utoimmune diseases and allergic disease such as atopic dermatitis and asthma. However, limited data is available on the vitamin D status in patients with chronic urticaria.
Objective: The goal of the present study was to investigate the relationship between vitamin D status and clinical characteristics of chronic urticaria.
Methods: The clinical records from December 2013 to October 2014 were reviewed retrospectively. 72 patients of chronic urticaria, 72 healthy controls, 26 patients of acute rticaria and 26 patients of atopic dermatitis who visited the outpatient clinic of the Department of Dermatology and Familiy Medicine, Eulji University Hospital were included in this study. I analyzed the serum serum 25-(OH)D3 status with various clinical parameters for chronic urticaria; result of autologous serum skin test(ASST), disease duration, urticaria activity score, age, sex and season.
Results: The serum 25-(OH)D3 level was significantly reduced in patients with chronic urticaria compared with acute urticaria (p = 0.024), atopic dermatitis (p = 0.008) and healthy controls (p < 0.001). In particular, the prevalence of vitamin D critically low level (< 10 ng/ml) was significantly higher in patients with chronic urticaria than that observed in acute urticaria (26%) (p < 0.002), atopic dermatitis (28%) (p < 0.004) and healthy controls (8%) (p < 0.001). The ASST positive patients had the lower vitamin D level than the ASST negative patients (p = 0.034). In chronic urticaria patient, the serum vitamin D levels showed the significant negative associations with urticaria acitivity score (UAS) (p < 0.001). Also, the serum vitamin D levels showed the significant negative associations with disease duration (p < 0.001).
Conclusion: I found that, in chronic urticaria patient, the serum vitamin D levels were critically low (< 10 ng/ml). Also, serum vitamin D status was inversely related to the disease severity and disease duration of the chronic urticaria patient. Therefore, it might be possible that vitamin D is supposed to be involved in the pathogenesis of chronic urticaria, and these findings may open up the possibility of clinical use of vitamin D as a predictive marker for the disease activity in chronic urticaria.

목차 (Table of Contents)

• ABSTRACT = ⅰ
• TABLE OF CONTENTS = ⅲ
• LIST OF TABLES = ⅳ
• LIST OF FIGURES = v
• Ⅰ. INTRODUCTION = 1
• Ⅱ. Materials AND METHODS = 8
• Ⅲ. RESULTS = 10
• Ⅳ. DISCUSSION = 29
• Ⅴ. CONCLUSION = 34
• REFERENCES = 35
• 국문요지 = 40