Methyl methacrylate-butyl methacrylate copolymer (MMBM)-povidone (PVP) films were investigated as a potential topical drug delivery system for the controlled release of econazole nitrate as a model drug. The effect of changes in film composition, drug...
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RISS 인기검색어
https://www.riss.kr/link?id=T6814057
- 저자
-
발행사항
서울 : 同德女子大學校 大學院, 1998
-
학위논문사항
학위논문(박사) -- 同德女子大學校 大學院 , 食品營養學科 , 1998. 2
-
발행연도
1998
-
작성언어
한국어
-
KDC
594.1
-
발행국(도시)
서울
-
형태사항
vi, 101 p. : 표. ; 26 cm.
-
일반주기명
참고문헌 :p.77 - 99
-
소장기관
- 국립중앙도서관
- 단국대학교 율곡기념도서관(천안)
- 동덕여자대학교 도서관
- 세종대학교 도서관
- 한성대학교 도서관
- 국립중앙도서관
-
0
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부가정보
다국어 초록 (Multilingual Abstract)
Methyl methacrylate-butyl methacrylate copolymer (MMBM)-povidone (PVP) films were investigated as a potential topical drug delivery system for the controlled release of econazole nitrate as a model drug. The effect of changes in film composition, drug concentration, film thickness, pH and temperature of release medium on the in vitro release of econazole nitrate were studied. The release rate constant was found to be increased with increasing povidone content in dry films. Drug release followed zero-order kinetics in the initial stage and then release rate increased gradually with time, espicially in the films having larger proportions of PVP. The release rate was found to be dependent on drug content, film thickness, the pH and temperature of release medium. Antimicrobial test showed that microbial growth was inhibited markedly with increasing proportions of PVP in films. Also drug content and film thickness affected the antimicrobial activity.
Methyl methacrylate-butyl methacrylate copolymer (MMBM)-povidone (PVP) films were investigated as a potential topical drug delivery system for the controlled release of econazole nitrate as a model drug. The effect of changes in film composition, drug concentration, film thickness, pH and temperature of release medium on the in vitro release of econazole nitrate were studied. The release rate constant was found to be increased with increasing povidone content in dry films. Drug release followed zero-order kinetics in the initial stage and then release rate increased gradually with time, espicially in the films having larger proportions of PVP. The release rate was found to be dependent on drug content, film thickness, the pH and temperature of release medium. Antimicrobial test showed that microbial growth was inhibited markedly with increasing proportions of PVP in films. Also drug content and film thickness affected the antimicrobial activity.
목차 (Table of Contents)
- 목차
- I. 서론 = 1
- II. 실험방법 = 4
- 1. 재료 및 기기 = 4
- 2. 필름의 제조 = 4
- 목차
- I. 서론 = 1
- II. 실험방법 = 4
- 1. 재료 및 기기 = 4
- 2. 필름의 제조 = 4
- 3. 필름의 두께 측정 = 6
- 4. 용해도 측정 = 6
- 5. 방출속도 측정 = 6
- 6. 항균 시험 = 7
- III. 실험결과 및 고찰 = 8
- 1. 수종 수용성 첨가제가 약물방출에 미치는 영향 = 8
- 2. 포비돈 분자량이 약물방출에 미치는 영향 = 8
- 3. 포비돈 첨가량이 방출속도에 미치는 영향 = 12
- 4. 약물의 첨가농도가 방출속도에 미치는 영향 = 14
- 5. 필름두께가 방출속도에 미치는 영향 = 15
- 6. 시험액의 pH가 방출속도에 미치는 영향 = 15
- 7. 시험액의 온도가 방출속도에 미치는 영향 = 18
- 8. 포비돈의 첨가량이 항균효과에 미치는 영향 = 19
- IV. 결론 = 23
- 참고문헌 = 24
- 영문초록 = 28
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