종합건강검진 수검자들의 비만수준과 혈압, 혈액 및 혈액생화학적 지표와의 관련성

다국어 초록 (Multilingual Abstract)

The purpose of the present study was to investigate the association of blood pressures, hematological and blood biochemical properties according to the degree of obesity based on differential combinations of BMI in health checkup examinees. Study subjects were 3,731 adults of 20 years and over (2,312 males, 1,419 females), not recognized as taking medicines for or having cardiovascular diseases, who underwent health package check-up at the in Daejon branch of Korea Health Management Association from Jan. 2007 to Dec. 2008.
The variables studied were divided into two broad categories and their relation was examined: obesity index as a BMI, and blood pressures and blood biochemical properties as a SBP, DBP, FBS, WBC, RBC, Hb, Hct, AST, ALT, GGT, ALP, TC, HDL-C, LDL-C and ALP. To reveal the relation between obesity index(BMI) and the proportion of individuals at risk for blood pressures and blood biochemical properties, the obesity indices were stratified and odds ratios were obtained after age adjustment. The major findings of the present study are as follows:

1. The rates according to the degree of obesity of study subjects were 4.6% in low weight group, 44.3% in normal weight group, 25.0% in over weight group and 26.1% in obesity group. The over weight group were significantly higher in 40's age group than other groups, and the obesity group were significantly higher in 50's age group than other groups.

2. Based on blood pressure, the rates of abnormal SBP was 54.2% in male, 45.3% in female, and DBP was 54.4% in male, 40.8% in female. By sexual comparison of rates of abnormal SBP and DBP, male were significantly higher than female. With respect to degree of BMI, the rates of abnormal SBP and DBP were significantly increased with higher level of BMI.

3. Based on hematological parameters, the rates of abnormal Hb was 7.0% in male, 9.4% in female, and Hct was 4.4% in male, 19.5% in female. By sexual comparison of rates of abnormal Hb and Hct, female were significantly higher than male. With respect to degree of BMI, the rates of abnormal Hb and Hct were significantly increased with lower level of BMI.

4. Based on biochemical parameters, the rates of abnormalities were as follows; TG was 41.8% in male, 21.8% in female, TC was 36.1% in male, 27.8% in female, HDL-C was 12.6% in male, 29.9% in female, LDL-C was 20.8% in male, 17.8% in female. By sexual comparison of abnormal rates, male were significantly higher than female in TG, TC, LDL-C, but HDL-C was significantly higher in female than that of male. With respect to degree of BMI, the abnormal rates of TG, TC, HDL-C and LDL-C were significantly increased with higher level of BMI.

5. The rates of abnormalities in liver blood enzyme were as follows; ALT was 5.3% in male, 1.5% in female, AST was 20.1% in male, 4.7% in female, GGT was 22.1% in male, 35.7% in female, GGT was 22.1% in male, 35.7% in female, ALP was 0.9% in male, 3.3% in female. With respect to degree of BMI, the rates of abnormal ALT, AST, GGT and ALP were significantly increased as BMI increased.

6. The age-adjusted odds ratio on the abnormal level of SBP, DBP, TG, TC, HDL-C, LDL-C, AST, ALT and GGT were significantly increased in overweight group and obese group than that of normal weight group. But Hct was significantly decreased in obese group than that of normal weight group.

7. Based on the result of ordinal logistic regression analysis, the risk ratio to the abnormal level of SBP, DBP, TG, TC, ALT, GGT and ALP were significantly increased as BMI increased in male, and in female, the abnormal level of SBP, DBP, TG, HDL-C, GGT and ALP were significantly increased as BMI increased.

The study results showed that the abnormal level of blood pressure, hematological and blood biochemical parameters were significantly increased as BMI increased. Specifically, the abnormal level of these parameters were significantly increased in overweight group and obese group than that of normal weight group in both sex group. It is suggested that the increase of BMI was increase the risk ratio of abnormal level of SBP, DBP, TG, TC, HDL-C, ALT, GGT and ALP.

목차 (Table of Contents)

• Ⅰ. 서 론 1
• Ⅱ. 연구 방법 4
• 1. 조사대상 4
• 2. 조사방법 4
• 3. 자료처리 및 분석 6
• Ⅲ. 연구 결과 8
• 1. 성별, 연령별 BMI 분포 8
• 2. BMI 구분에 따른 혈압, 혈액 및 혈액생화학적 지표의 비교 10
• 1) BMI 구분에 따른 평균 혈압 및 혈당치의 비교 10
• 2) BMI 구분에 따른 평균 혈액학치의 비교 12
• 3) BMI 구분에 따른 평균 혈청지질치의 비교 14
• 4) BMI 구분에 따른 평균 혈액효소치의 비교 16
• 3. BMI 구분에 따른 혈압, 혈액 및 혈액생화학적 지표의 비정상치 분포 18
• 1) BMI 구분에 따른 혈압 및 혈당의 비정상치 분포 18
• 2) BMI 구분에 따른 혈액학치의 비정상치 분포 20
• 3) BMI 구분에 따른 혈청지질치의 비정상치 분포 22
• 4) BMI 구분에 따른 혈액효소치의 비정상치 분포 24
• 4. BMI와 혈압, 혈액 및 혈액생화학적 지표와의 상관관계 65
• 5. BMI 구분에 따른 혈압, 혈액 및 혈액생화학적 지표의 위험비 비교 28
• 6. BMI 중증도에 따른 혈압, 혈액 및 혈액생화학적 지표의 위험비 증가에 대한 순서형 다변량 로지스틱 회귀분석 결과 31
• Ⅳ. 고 찰 33
• Ⅴ. 결 론 38
• 참고문헌 41
• ABSTRACT 47