Pectin-Gelatin Complex Conservation에 의한 Indomethacin 의 Microencapsulation에 관한 연구 = MICROENCAPSULATION OF INDOMETHACIN BY PECTIN-GELATIN COMPLEX COACERVATION METHOD

국문 초록 (Abstract)

Pectin-gelatin complex coacervation system을 이용하여, 위장관장애가 보고되는 비스테로이드성 소염진통제인 Indomethacin을 핵물질로 하는 microcapsule을 조제하였다.
Microencapsulation시의 최적의 pH는 3.8 이었으며, 가장 적절한 pectin과 gelatin의 비율은 1 : 2였다.
Pectin용액 및 gelatin용액의 colloid농도를 1%, 1.5% 및 2%로 하였을 때, 농도가 증가할수록 microcapsule의 막두께는 두꺼워졌다 용출속도는 Indomethacin분말에 비해 크게 촉진되었는데 1.5% 및 2%의 colloid의 용액으로 조제한 경우에서는 거의 비슷하였으나, 1% colloid용액으로 조제한 Indomethacin-pectin-gelatin microcapsule보다는 용출이 지연되었다. 즉 pH 7.2인산염완충액 : 증류수( 1 : 4V/V)의 용출용매에서 T_(50%)은 Indomethacin분말이 50분인데 비하여 colloid 농도가 1%, 1.5% 및 2%의 경우는 3분, 5분, 6분으로 더 빨라졌다.
Scanntng Electron micrography로 관찰된 Indomethacin-pectingelatin microcapsule은 표면에 주름 (folding과 invagination)이 관찰되었다.

다국어 초록 (Multilingual Abstract)

Indomethacin, a non-steroidal antiinflammatory drug inducing gastric irritation, was microencapsulated using pectin-gelatin complex coacervation method. Optimum conditions for microencapsulation and dissolution characteristics of microcapsules were studied.
Optimum pH and pectin-gelatin ratio for microencapsulation were 3.8 and 1:2 respectively.
As concentration of colloid solution increased, wall thickness of microcapsules were increased.
The dissolution rate of Indomethacin-pectin-gelatin microcapsules prepared by 1.5% and 2% colloid solution were similar but slower than that of Indomethacin-pectin-gelatin microcapsules prepared by 1% colloid solution.
The 50% release time (T_(50%)) of Indomethacin-pectin-gelatin microcapsules prepared by 1%, 1.5% and 2% colloid solutions were 3min, 5min, and 6min respectively while that of Indomethacin powder was 50min.
Surface of microcapsules was found to be folded and invaginated by Scanning Electron Micrography.

목차 (Table of Contents)

• 목차 = ⅲ
• 論文槪要 = ⅶ
• Ⅰ. 序論 = 1
• Ⅱ. 實驗 및 方法 = 5
• 1. 試藥 = 5
• 2. 試驗機器 = 5
• 3. 實驗方法 = 6
• Ⅲ. 結果 및 考察 = 11
• Ⅳ. 結論 = 34
• 參考文獻 = 35
• ABSTRACT = 39