Synthesis of 5'-substituted fluoro-neplanocin A analogues|RISS 상세보기

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Synthesis of 5'-substituted fluoro-neplanocin A analogues

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https://www.riss.kr/link?id=E873559

저자

Moon, Hyung-Ryong ; Lee, Hyun-Joo ; Kim, Kyung-Ran ; Lee, Kang-Man ; Lee, Sang-Kook ; Kim, Hea-Ok ; Chun, Moon-Woo ; Jeong, Lak-Shin
발행기관

이화여자대학교 약학연구소
발행연도
2004년
작성언어
English
자료형태

dCollection
수록면
58-61

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다국어 초록 (Multilingual Abstract)

Four 5'-substituted fluoro-neplanocin A analogues la-d were designed and synthesized, using cyclopentenone derivative 2 as a key intermediate. The inhibitory activity against SAH was in the following order: NH₂>SH>F, N₃, indicating a hydrogen bonding donor such as OH or NH₂was essential for inhibitory activity. All the final compounds showed much less decreased cytotoxicity in two cancer cell lines(Col2 and A549), implying that phosphorylation of the 5'-hydroxyl group of fluoro-neplanocin A is closely related to its high cytotoxicity.

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Four 5'-substituted fluoro-neplanocin A analogues la-d were designed and synthesized, using cyclopentenone derivative 2 as a key intermediate. The inhibitory activity against SAH was in the following order: NH₂>SH>F, N₃, indicating a hydroge...

Four 5'-substituted fluoro-neplanocin A analogues la-d were designed and synthesized, using cyclopentenone derivative 2 as a key intermediate. The inhibitory activity against SAH was in the following order: NH₂>SH>F, N₃, indicating a hydrogen bonding donor such as OH or NH₂was essential for inhibitory activity. All the final compounds showed much less decreased cytotoxicity in two cancer cell lines(Col2 and A549), implying that phosphorylation of the 5'-hydroxyl group of fluoro-neplanocin A is closely related to its high cytotoxicity.