Polypeptide Growth Factor가 사람 잇몸과치주인대 섬유모세포의 세포증식 및 Hyaluronan 합성에 미치는 영향에 관한 연구 = MITOTIC AND HYALURONAN SYNTHTIC RESPONSE OF HUMAN GINGIVAL AND PERIODONTAL LIGAMENT FIBROBLASTIC CELLS TO POLYPEPTIDE GROWTH FACTORS

다국어 초록 (Multilingual Abstract)

Growth factors regulate the biological behaviors including mitosis and protein synthesis of the several types of cells. Hyaluronan plays an important role in the cell attachment, migration, and proliferation during the wound healing. It is expected that hyaluronan is also important in the periodonatal regeneration. The present study was designed to investigate the effect of growth factors - PDGF, TGF-β1, IGF-I, and EGF - on the proliferationof the human gingival and periodontal ligament fibroblasts which is the most important cells in the healing processes of the periodontal wound. At the same time, the role of hyaluronan during the cell proliferation and the effect of bFGF and PDGF on the hyaluronan synthesis of the cells were also investigated using explanted human gingival and periodontal ligament fibroblasts.
The results are as follows,
1. PDGF stimulates the proliferation of the gingival fibroblasts and TGF-β1 stimulates that of the periodontal ligament fibroblasts greatly.
2. Hyaluronan inhibits the DNA synthesis of human gingival and periodontal ligament fibroblasts. The tendency is more apparent in the gingival fibroblast.
2. Hyaluronan keeps the fibroblasts from entering the S phase of the cell cycle.
3. bFGF stimulates the hyaluronan synthesis of the gingival fibroblasts greatly.
4. Neither bFGF nor PDGF stimulates the hyaluronan synthesis of the periodontal ligament fibroblasts.
These results suggest that growth factors may accelerate the periodontal regeneration by stimulating the HA synthesis.

목차 (Table of Contents)

• 1.서론
• 2.실험재료 및 방법
• 3.실험성적
• 4.총괄 및 고안
• 5.결론
• References