Alteration of collapsin response mediator protein-2 expression in focal ischemic rat brain

다국어 초록 (Multilingual Abstract)

Collapsin response mediator protein-B is highly expressed in the adult brain and it has been speculated to piay roles in nervous. system diseases. Studies determined for the first time whether collapsin response mediator protein-1 expression is altered in brain ischemia We observed Ischemla-modulated expression of different-sized collapsln response mediator protein-2 As the ischemic duratlon increased, the expression level of a known major 62kDa collapsln response mediator protein-2 was decreased, whereas the expression of a newly-detected 58 kDa collapsin response mediator Protein-2 was clearly increased in middle carotid artery-occluded rat brain tissues. Analysis of the two collapsin response mediator protein-2 bands revealed that the novel 58kDa collapsln response mediator protein-2 observed in middle carotid artery-occluded rat brain tissues was a cleavage form; the predicted cleavage site is totaled at the carboxy-terminal of the collapsln response mediator protein-2. These data suggest that collapsln response mediator protein-2 is an important candidate controlling ischemic stroke.