Intrapancreatic ectopic splenic tissue found in a cloned miniature pig

다국어 초록 (Multilingual Abstract)

Somatic cell nuclear transfer (SCNT) is a cost-effective technique for producing transgenic pigs. However, abnormalities in the cloned pigs might prevent use these animals for clinical applications or disease modeling. In the present study, we generated several cloned pigs. One of the pigs was found to have intrapancreatic ectopic splenic tissue during histopathology analysis although this animal was grossly normal and genetically identical to the other cloned pigs. Ectopic splenic tissue in the pancreas is very rare, especially in animals. To the best of our knowledge, this is the first such report for cloned pigs.

참고문헌 (Reference)

1 Cibelli JB, "The health profile of cloned animals" 20 : 13-14, 2002

2 이병철, "Successful surgical correction of anal atresia in a transgenic cloned piglet" 대한수의학회 6 (6): 243-245, 2005

3 Bundza A, "Some heterotopic tissue remnants in domestic animals" 19 : 322-324, 1978

4 Cho SK, "Serial cloning of pigs by somatic cell nuclear transfer:restoration of phenotypic normality during serial cloning" 236 : 3369-3382, 2007

5 Ramírez GA, "Intrapancreatic ectopic splenic tissue in dogs and cats" 148 : 361-364, 2013

6 Arkadopoulos N, "Intrapancreatic accessory spleen issues: diagnostic and therapeutic challenges" 10 : 400-405, 2009

7 Galli C, "Genetic engineering including superseding microinjection: new ways to make GM pigs" 17 : 397-410, 2010

8 Cho B, "Generation of soluble human tumor necrosis factor-α receptor 1-Fc transgenic pig" 92 : 139-147, 2011