마황이 사람 기관이 상피세포주의 TARC 분비에 대한 효과 = Effect of Ephedrae Herba on Release of Thymus and Activation Regulated Chemokine in Human Bronchial Epithelial Cell마황이 사람 기관이 상피세포주의 TARC 분비에 대한 효과

다국어 초록 (Multilingual Abstract)

Recent reports have proposed that Ephedrae Herba may modulate the immune response on allergy or asthma. Chemokines are important for the recruitment of leukocytes to sites of infection, which is essential in host defense. The thymus and activation-regulated chemokine (TARC) is a CC chemokine which potentially plays a role via a paracrine mechanism in the development of allergic respiratory diseases. Objectives : The objective of this study is to investigate the effect of Ephedrae Herba on the secretion of TARC of human bronchial epithelial cell Methods : Enzyme-Linked Immunosorbent Assay (ELISA) was performed to detect the secretion of TARC . The cytotoxicity was measured by MTT assay. Results : Ephedrae Herba significantly inhibited the secretion of TARC with a dose-dependant manner. The effective dosage did not have the cytotoxicity on human bronchial epithelial cell. Conclusion : Results of our study show that Ephedrae Herba would play an important role in modulation of TARC in Human bronchial epithelial cells.