Outcomes of endoscopic submucosal dissection for superficial esophageal neoplasms in patients with liver cirrhosis

다국어 초록 (Multilingual Abstract)

Background/Aims: The treatment of superficial esophageal neoplasms (SENs) in cirrhotic patients is challenging and rarely investigated.
We evaluated the outcomes of endoscopic submucosal dissection (ESD) to determine the efficacy and safety of treating SENs in patientswith liver cirrhosis.
Methods: The baseline characteristics and treatment outcomes of patients who underwent ESD for SENs between November 2005 andDecember 2017 were retrospectively reviewed.
Results: ESD was performed in 437 patients with 481 SENs, including 15 cirrhotic patients with 17 SENs. En bloc resection (88.2% vs.
97.0%) and curative resection (64.7% vs. 78.9%) rates were not different between the cirrhosis and non-cirrhosis groups (p=0.105 andp=0.224, respectively). Bleeding was more common in cirrhotic patients (p=0.054), and all cases were successfully controlled endoscopically.
The median procedure and hospitalization duration did not differ between the groups. Overall survival was lower in cirrhoticpatients (p=0.003), while disease-specific survival did not differ between the groups (p=0.85).
Conclusions: ESD could be a safe and effective treatment option for SENs in patients with cirrhosis. Detailed preprocedural assessmentsare needed, including determination of liver function, esophageal varix status, and remaining life expectancy, to identify patientswho will obtain the greatest benefit.

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