In an attempt to define the early biochemical determinants that participate in the pathogenesis of mercuric chloride-induced nephrotoxicity, especially focusing on oxygen free radicals, we studies malondialdehyde(MDA) level and catalase activity in re...
In an attempt to define the early biochemical determinants that participate in the pathogenesis of mercuric chloride-induced nephrotoxicity, especially focusing on oxygen free radicals, we studies malondialdehyde(MDA) level and catalase activity in renal cortex of the rats at 24, 48 and 72 hr after the injection of mercuric chloride.
Wistar albino rats weighing 180 to 220gm were injected subcutaneously with mercuric chloride(HgCl₂, 2mg/kg).
The result obtained can be summarized as follows:
1.The group treated with mercuric chloride showed significantly lower MDA level at 24, 48 and 72hr after the infection as compared to that of control group.
2.The group treated with mercuric chloride showed significantly higher catalase activity at 24hr and lower catalase activity at 72hr after the infection as compared to that of control group.
These results suggest that the excessive oxygen free radicals resulting from the depression of catalase activity is an important determinant in pathogenesis of mercuric chloride-induced nephrotoxicity.