본 연구에서는 제주도 자생 감귤 17종에 대하여 탈색소효과(depigment effect)를 연구하였다. B16 멜라닌 생성세포(B16 melanoma cell)를 이용하여 tyrosinase 및 멜라닌 생성억제 효과를 연구한 결과 대조...
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https://www.riss.kr/link?id=A106180991
2007
-
KCI등재후보
학술저널
69-77(9쪽)
7
0
상세조회0
다운로드국문 초록 (Abstract)
본 연구에서는 제주도 자생 감귤 17종에 대하여 탈색소효과(depigment effect)를 연구하였다. B16 멜라닌 생성세포(B16 melanoma cell)를 이용하여 tyrosinase 및 멜라닌 생성억제 효과를 연구한 결과 대조...
본 연구에서는 제주도 자생 감귤 17종에 대하여 탈색소효과(depigment effect)를 연구하였다. B16 멜라닌 생성세포(B16 melanoma cell)를 이용하여 tyrosinase 및 멜라닌 생성억제 효과를 연구한 결과 대조군 대비하여 농도 의존적으로 감소하는 3종의 미성숙 온주밀감(immature Citrus unshue), 팔삭(Citrus hassaku), 진지향(Citrus sinensis x reticulata)을 도출하였다. 또한, 이와 같이 도출된 감귤 추출물을 이용하여 멜라닌 세포 생성(melanogenesis)에 영향을 미치는 tyrosinase, DOPAchrome tauto-merase (TRP-2)와 DHICA oxidase (TRP-1) 단백질 발현을 실험한 결과 tyrosinase, TRP-1, TRP-2 단백질 발현이 감소함을 나타내었다. 특히 이들 중 미성숙 온주밀감은 tyrosinase와 TRP-1 단백질 발현에서 유의적으로 감소하는 결과를 보였다. 본 연구 결과로써 미성숙 온주밀감은 모든 실험에서 우수한 효과를 나타내어 UV에 의해서 야기되는 피부 색소 침착을 방지할 수 있는 물질로서 기대할 수 있다.
다국어 초록 (Multilingual Abstract)
We examined the depigmentation effect on Korean traditional citrus 17 species. With B16 melanoma cells, we have seen inhibition of the tyrosinase and melanin formation, which eventually were dose dependently decreased by three citrus fruits, immature ...
We examined the depigmentation effect on Korean traditional citrus 17 species. With B16 melanoma cells, we have seen inhibition of the tyrosinase and melanin formation, which eventually were dose dependently decreased by three citrus fruits, immature Citrus unshiu, Citrus hassaku, and Citrus sinensis × reticulata as compared with positive control. Also, we examined expression of tyrosinase, DOPAchrome tautomerase (TRP-2), and DHICA oxidase (TRP-1) which affect melanin synthesis. Especially, immature Citrus unshiu decreased the protein levels of tyrosinase and TRP-1. In conclusion, immature Citrus unshue showed the strongest activity in all the experiments mentioned above and we expect that it can be used for preventing UV-induced pigmentation.
참고문헌 (Reference)
1 Kobayashi, "functions as a DHICA oxidase in melanin biosynthesis" 1994
2 V. del Marmol, "Tyrosinase and related proteins in mammalian pigmentation" 381 : 165-, 1996
3 A, "Treatment of melasma with potent topical corticosteroids" 1994
4 A, "Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-in- flammatory polymethoxyflavonoid" 12 : 187-, 2000
5 A. L. Kadekaro, "Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival" 994 : 359-, 2003
6 Hoganson, "Regulation of tyrosinase mRNA levels in mouse melanoma cell clones by melanocyte-stimulating hormone and cyclic AMP" 1989
7 Eller, "Pigment content of cultured human melanocytes does not correlate with tyro-sinase message level" 1991
8 R. G. Christine, "NO Produced by Ultraviolrt-irradiated keratinocytes Stimulates Melanogenesis" 99 : 635-, 1997
9 S. Y. Seo, "Mushroom tyrosinase: recent prospects" 51 : 2837-, 2003
10 A, "Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin" 1982
1 Kobayashi, "functions as a DHICA oxidase in melanin biosynthesis" 1994
2 V. del Marmol, "Tyrosinase and related proteins in mammalian pigmentation" 381 : 165-, 1996
3 A, "Treatment of melasma with potent topical corticosteroids" 1994
4 A, "Suppressive effects of citrus fruits on free radical generation and nobiletin, an anti-in- flammatory polymethoxyflavonoid" 12 : 187-, 2000
5 A. L. Kadekaro, "Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival" 994 : 359-, 2003
6 Hoganson, "Regulation of tyrosinase mRNA levels in mouse melanoma cell clones by melanocyte-stimulating hormone and cyclic AMP" 1989
7 Eller, "Pigment content of cultured human melanocytes does not correlate with tyro-sinase message level" 1991
8 R. G. Christine, "NO Produced by Ultraviolrt-irradiated keratinocytes Stimulates Melanogenesis" 99 : 635-, 1997
9 S. Y. Seo, "Mushroom tyrosinase: recent prospects" 51 : 2837-, 2003
10 A, "Mammalian tyrosinase catalyzes three reactions in the biosynthesis of melanin" 1982
11 Hearing, "Mammalian tyr- osinase-the critical regulatory control point in me- lanocyte pigmentation" 1987
12 J. Yamakoshi, "Lightening effect on ultraviolet-induced pigmentation of guinea pig skin by oral administration of a proanthocyanidin- rich extract from grape seeds" 16 : 629-, 2003
13 E. V. Curto, "Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors" 57 : 663-, 1999
14 M. Seiberg, "Inhibition of melanosome transfer results in skin lightening" 115 : 162-, 2000
15 Karg, "Hydrogen peroxide as an inducer of elevated tyrosinase level in melanoma cells" 1993
16 A, "Eumelanin biosynthesis is regulated by coordinate expression of tyrosinase and tyrosinase-related protein-1 genes" 1993
17 R. Busca, "Cyclic AMP a key messenger in the regulation of skin pigmentation" 13 : 60-, 2000
18 H. Ando, "Correlation between the number of melanosomes, tyrosinase mRNA levels, and tyrosinase activity in cultured murine melanoma cells in response to various melanogenesis regulatory agents" 163 : 608-, 1995
19 Yokoyama, "Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression" 1994
20 W. Ma, "Chronological ageing and photoageing of the fibroblasts and the dermal connective tissue" 26 : 592-, 2001
21 H. Yasui, "Age-dependent generation of reactive oxygen species in the skin of live hairless rats exposed to UVA light" 12 : 655-, 2003
음이온 계면활성제에서 파파인 효소의 안정도에 관한 연구
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2027 | 평가예정 | 재인증평가 신청대상 (재인증) | |
2021-03-19 | 학회명변경 | 한글명 : 대한화장품학회 -> 사단법인 대한화장품학회 | |
2021-01-01 | 평가 | 등재학술지 유지 (재인증) | |
2018-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2015-01-01 | 평가 | 등재학술지 선정 (계속평가) | |
2013-01-01 | 평가 | 등재후보 1차 FAIL (등재후보1차) | |
2012-01-01 | 평가 | 등재후보학술지 유지 (기타) | |
2011-01-01 | 평가 | 등재후보학술지 유지 (등재후보2차) | |
2010-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2009-01-01 | 평가 | 등재후보학술지 유지 (등재후보1차) | |
2007-01-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.45 | 0.45 | 0.4 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.35 | 0.38 | 0.531 | 0.02 |