Estimating the 10-Year Risk of Cardiovascular Disease and Its Economic Consequences, by the Level of Adherence to the Mediterranean Diet: The ATTICA Study

다국어 초록 (Multilingual Abstract)

In this study this traditional diet was assessed in relation to coronary heart disease risk and its economic con-sequences, in a cross-sectional study with economic analysis. From May 2001 to December 2002 we randomly enrolled 1,514adult men and 1,528 women, without any clinical evidence of cardiovascular disease. Adherence to the Mediterranean dietwas ascertained through a food-frequency questionnaire and a special diet score that incorporated the inherent characteristicsof this dietary pattern. The 10-year absolute risk for coronary heart disease was derived from the Framingham equations. Per-sons with a 10-year risk greater than 10% were considered as potential hospitalized patients. The health care cost of hospi-talization due to an event was estimated in 690A??per patient. Of the participants who were “closer” to the Mediterranean diet(i.e., above the median diet score) and of those “away” from this dietary pattern, 4.2% and 39.8%, respectively, had a 10-yearcoronary risk greater than 10% (P. .001). Moreover, participants “closer” to the Mediterranean diet had a 43% (odds ra-tio. 0.57, 95% confidence interval 0.38 to 0.86) lower likelihood of having a 10-year coronary risk greater than 10%, afteradjusting for potential confounders. Total health care cost was estimated to be 336.720A??in those who were “away” and 35.880A??in those who were closer to this diet pattern. Life-years lost due to disability was 6.8 in those who were “away” and0.9 in those “close” to this pattern. The incremental cost-effectiveness ratio was 50.989A??(i.e., the additive health care costdue to an unhealthy diet for each year lost). The implementation of the Mediterranean dietary pattern may lead to an im-provement in life expectancy, a net gain to health, and a reduction in total lifetime costs.

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