藥鍼이 Freund's Complete Adjuvant와 Peptidoglycan Polysaccharide에 의해서 誘發된 白鼠의 關節炎에 미치는 영향 = Effects of Bovis Calculus, Susi Fei Aqua-acupuncture on Arthritis induced by Freund's Complete Adjuvant and Peptidoglycan Polysaccharide in Rats

국문 초록 (Abstract)

最近에 藥鍼療法이 많은 관심을 끌고 있다. 독특한 潤氣·六元의 原理에 依據하여 生體의 機能을 調整하고 病理狀態를 改變시켜, 疾病을 治療하는 新鍼療法중 하나이다. 이런 藥鍼療法은 매우 多樣한 疾患에 應用되고 있는데, 關節炎 治療에도 適用되고 있다. 牛黃·熊膽 藥鍼과 牛黃·猪膽 藥鍼의 效果를 比較 檢討하기 위하여 Freund's complete adjuvant와 peptidoglycan polysaccharide를 使用하여 關節炎을 誘發시킨 흰쥐에게 藥鍼을 施行하여 그 效果를 觀察하였다. Radioimmunoassy에 의한 PGE_2 含量을 測定하여 鎭痛 및 抗炎反應을 살펴보았고, 血液學的 檢査도 施行하였다. 또한 組織學的 所見을 觀察하여 組織의 損傷에 대한 回復程度를 比較檢討하였다.

다국어 초록 (Multilingual Abstract)

In order to investigate experimentally that Bovis Calculus, Ursi Fei Aqua-acupuncture(BUA) and Bovis Calculus, Susi Fei Aqua-acupuncture(BSA) have an effect on Arthritis in rats, the author inserted Aqua-acupuncture, electro-acupuncture, aspirin at corresponding with Chok-samni(ST36) and Hyunjong(GB39), and observed an concentration of the serum PGE_2 by method of the radioimmunoassay. The author also observed the histological feature of knee joint tissue.
The results were as follows:
1. The BUA & BSA & aspirin group were decreased with statistical significance in the concentration of the serum PGE_2 as compared with the control group.
2. The BSA group were decreased with statistical significance in blood WBC as compared with the control group.
3. The control & experimental group were increased in blood RBC, Hb, Hct and decreased MCV, MCH as compared with the control group.
4. According to the histological studies, the BUA & BSA group were showed less than the control group in the damage of synovial cells and the least damage of synovial cells were showed in aspirin injection group.